Polymorphisms in NR3C1 gene associated with risk of metabolic syndrome in a Chinese population

Endocrine

Volumn 47, Issue 3, 2014, Pages 740-748

  Yan, Yu Xiang ^a   Dong, Jing ^b   Zhang, Jie ^a   Liu, Fen ^b   Wang, Wei ^a   Zhang, Ling ^a   He, Yan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Glucocorticoid receptor; Metabolic syndrome; NR3C1; Polymorphism; Risk factor

Indexed keywords

GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; GLUCOCORTICOID RECEPTOR; NR3C1 PROTEIN, HUMAN;

ADULT; ARTICLE; BODY MASS; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HIGH RISK POPULATION; HIGH THROUGHPUT SEQUENCING; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NR3C1 GENE; PHYSICAL INACTIVITY; RECEPTOR GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; AGED; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHINA; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED;

ADULT; AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID;

EID: 84911976985     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0324-9     Document Type: Article

References (26)

1. D.E. Moller, K.D. Kaufman, Metabolic syndrome: a clinical and molecular perspective. Annu. Rev. Med. 56, 45–62 (2005)
2. K.L. Tamashiro, R.R. Sakai, C.A. Shively, I.N. Karatsoreos, L.P. Reagan, Chronic stress, metabolism, and metabolic syndrome. Stress 14(5), 468–474 (2011)
3. G.P. Chrousos, T. Kino, Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 10, 213–219 (2007)
4. J. Zhou, J.A. Cidlowski, The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70, 407–417 (2005)
5. D. Duma, C.M. Jewell, J.A. Cidlowski, Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J. Steroid Biochem. Mol. Biol. 102, 11–21 (2006)
6. N.C. Nicolaides, Z. Galata, T. Kino, G.P. Chrousos, E. Charmandari, The human glucocorticoid receptor: molecular basis of biologic function. Steroids 75, 1–12 (2010)
7. S.W. Lamberts, A.T. Huizenga, P. de Lange, F.H. de Jong, J.W. Koper, Clinical aspects of glucocorticoid sensitivity. Steroids 61, 157–160 (1996)
8. P. Smit, H. Russcher, F.H. de Jong, A.O. Brinkmann, S.W. Lamberts, J.W. Koper, Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2. J. Clin. Endocrinol. Metab. 90, 2994–3000 (2005)
9. E.F. van Rossum, S.W. Lamberts, Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog. Horm. Res. 59, 333–357 (2004)
10. R.C. Lin, X.L. Wang, B. Dalziel, I.D. Caterson, B.J. Morris, Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes. Res. 11, 802–808 (2003)
11. R. Rosmond, Y.C. Chagnon, G. Holm, M. Chagnon, L. Pérusse, K. Lindell et al., A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes. Res. 8, 211–218 (2000)
12. E.F. Van Rossum, J.W. Koper, N.A. Huizenga, A.G. Uitterlinden, J.A. Janssen, A.O. Brinkmann et al., A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51, 3128–3134 (2002)
13. E.F. Van Rossum, P.H. Roks, F.H. De Jong, A.O. Brinkmann, H.A. Pols, J.W. Koper et al., Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms. Clin. Endocrinol. (Oxf) 61, 573–581 (2004)
14. E. Charmandari, T. Ichijo, W. Jubiz, S. Baid, K. Zachman, G.P. Chrousos et al., A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. J. Clin. Endocrinol. Metab. 93, 4963–4968 (2008)
15. A.A. Syed, J.A. Irving, C.P. Redfern, A.G. Hall, N.C. Unwin, M. White et al., Association of glucocorticoid receptor polymorphism A3669G in exon 9beta with reduced central adiposity in women. Obesity (Silver Spring) 14, 759–764 (2006)
16. Porzezińska-Furtak J, Krzyżanowska-Świniarska B, Miazgowski T, Safranow K, Kamiński R. Hypothalamic-pituitary-adrenal axis activity, personality traits, and BCL1 and N363S polymorphisms of the glucocorticoid receptor gene in metabolically obese normal-weight women. Endocrine. 45. doi:10.1007/s12020-014-0187-0 (2014)
17. Y.X. Yan, J. Dong, L.J. Wu, S. Shao, J. Zhang, L. Zhang et al., Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a Chinese population. J. Epidemiol. 23, 389–395 (2013)
18. K.G. Alberti, R.H. Eckel, S.M. Grundy, P.Z. Zimmet, J.I. Cleeman, K.A. Donato et al., Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120, 1640–1645 (2009)
19. J. Galon, D. Franchimont, N. Hiroi, G. Frey, A. Boettner, M. Ehrhart-Bornstein et al., Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB. J. 16, 61–71 (2002)
20. G.P. Chrousos, T. Kino, Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci. STKE. 2005, pe48 (2005)
21. P.J. Bray, R.G. Cotton, Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms. Hum. Mutat. 21, 557–568 (2003)
22. M. Panarelli, C.D. Holloway, R. Fraser, J.M. Connell, M.C. Ingram, N.H. Anderson et al., Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J. Clin. Endocrinol. Metab. 83, 1846–1852 (1998)
23. M. Panek, T. Pietras, A. Fabijan, M. Milanowski, L. Wieteska, P. Górski, P. Kuna, J. Szemraj, Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes. Exp. Ther. Med. 5, 572–580 (2013)
24. S.D. Detera-Wadleigh, I.J. Encio, D.Y. Rollins, D. Coffman, D. Wiesch, A Tth111I polymorphism on the 5′ flanking region of the glucocorticoid receptor gene (GRL). Nucleic Acids Res. 19, 1960 (1991)
25. E.F. Van Rossum, P.G. Voorhoeve, S.J. Te Velde, J.W. Koper, H.A.D. van de Waal, H.C. Kemper et al., The ER22, 23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J. Clin. Endocrinol. Metab. 89, 4004–4009 (2004)
26. A. Krupoves, D. Mack, C. Deslandres, E. Seidman, D.K. Amre, Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn’s disease. Pharmacogenet. Genomics 21, 454–460 (2011)