A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans

Journal of Cardiovascular Electrophysiology

Volumn 25, Issue 11, 2014, Pages 1150-1157

  Ilkhanoff, Leonard ^a   Arking, Dan E ^b   Lemaitre, Rozenn N ^c   Alonso, Alvaro ^d   Chen, Lin Y ^e   Durda, Peter ^f   Hesselson, Stephanie E ^g,h   Kerr, Kathleen F ⁱ   Magnani, Jared W ^j   Marcus, Gregory M ^g   Schnabel, Renate B ^j,k   Smith, J Gustav ^l,m   Soliman, Elsayed Z ⁿ   Reiner, Alexander P ⁱ   Sotoodehnia, Nona ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

ⁱ UNIVERSITY OF WASHINGTON   (United States)

^j BOSTON UNIVERSITY   (United States)

^k UNIVERSITY HEART CENTER HAMBURG   (Germany)

^l MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^m LUND UNIVERSITY   (Sweden)

ⁿ WAKE FOREST SCHOOL OF MEDICINE   (United States)

more..

Author keywords

atrial fibrillation; electrocardiogram; genetics; PR interval; sudden death

Indexed keywords

SODIUM CHANNEL NAV1.5; SCN5A PROTEIN, HUMAN;

ADULT; AFRICAN AMERICAN; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEART ATRIUM FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; PR INTERVAL; SUDDEN CARDIAC DEATH; AGED; ATRIAL FIBRILLATION; CASE CONTROL STUDY; COHORT ANALYSIS; GENETIC VARIATION; GENETICS; META ANALYSIS; MIDDLE AGED; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR; SINGLE BLIND PROCEDURE; VERY ELDERLY;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; COHORT STUDIES; DEATH, SUDDEN, CARDIAC; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PROSPECTIVE STUDIES; RISK FACTORS; SINGLE-BLIND METHOD;

EID: 84911932961     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12483     Document Type: Article

References (27)

1. Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT,: Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 2002; 297: 1333-1336.
2. Burke A, Creighton W, Mont E, Li L, Hogan S, Kutys R, Fowler D, Virmani R,: Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks. Circulation 2005; 112: 798-802.
3. Sun AY, Koontz JI, Shah SH, Piccini JP, Nilsson KR Jr, Craig D, Haynes C, Gregory SG, Hranitzky PM, Pitt GS,: The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circ Cardiovasc Genet 2011; 163-168.
4. Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen MH, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA Jr, Tracy RP, Vasan RS, Wilson JG, Kathiresan S, Fabsitz RR, Boerwinkle E, Gabriel SB,: NHLBI Candidate Gene Association Resource. Candidate gene association resource (CARe): Design, methods, and proof of concept. Circ Cardiovasc Genet 2010; 3: 267-275.
5. Chamberlain AM, Agarwal SK, Ambrose M, Folsom AR, Soliman EZ, Alonso A,: Metabolic syndrome and incidence of atrial fibrillation among blacks and whites in the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2010; 159: 850-856.
6. Smith JG, Platonov PG, Hedblad B, Engstrom G, Melander O,: Atrial fibrillation in the Malmo Diet and Cancer study: A study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol 2010; 25: 95-102.
7. Soliman EZ, Rautaharju PM,: Heart rate adjustment of PR interval in middle aged and older adults. J Electrocardiol 2012; 45: 66-69.
8. Smith JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C, Tanaka T, Mehra R, Butler AM, Young T, Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G, Ellinor PT, Magnani JW, Chen W, Bis JD, Curb JD, Hsueh WC, Rotter JI, Liu Y, Newman AB, Limacher MC, North KE, Reiner AP, Quibrera PM, Schork NJ, Singleton AB, Psaty BM, Soliman EZ, Solomon AJ, Srinivasan SR, Alonso A, Wallace R, Redline S, Zhang ZM, Post WS, Zonderman AB, Taylor HA, Murray SS, Ferrucci L, Arking DE, Evans MK, Fox ER, Sotoodehnia N, Heckbert SR, Whitsel EA, Newton-Cheh C,: CARe and COGENT consortia. Impact of ancestry and common genetic variants on QT interval in African Americans. Circ Cardiovasc Genet 2012; 5: 647-655.
9. Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, Kerr KF, Schnabel RB, Lubitz SA, Sotoodehnia N, Redline S, Pfeufer A, Müller M, Evans DS, Nalls MA, Liu Y, Newman AB, Zonderman AB, Evans MK, Deo R, Ellinor PT, Paltoo DN, Newton-Cheh C, Benjamin EJ, Mehra R, Alonso A, Heckbert SR, Fox ER,: Candidate-gene Association Resource (CARe) Consortium. Genome-wide association studies of the PR interval in African Americans. PLoS Genet 2011; 7: e1001304.
10. Smith JG, Lowe JK, Kovvali S, Maller JB, Salit J, Daly MJ, Stoffel M, Altshuler DM, Friedman JM, Breslow JL, Newton-Cheh C,: Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm 2009; 6: 634-641.
11. Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino RB Sr, Newton-Cheh C, Yamamoto JF, Magnani JW, Tadros TM, Kannel WB, Wang TJ, Ellinor PT, Wolf PA, Vasan RS, Benjamin EJ,: Development of a risk score for atrial fibrillation (Framingham Heart Study): A community-based cohort study. Lancet 2009; 373: 739-745.
12. Chamberlain AM, Agarwal SK, Folsom AR, Soliman EZ, Chambless LE, Crow R, Ambrose M, Alonso A,: A clinical risk score for atrial fibrillation in a biracial prospective cohort (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol 2011; 107: 85-91.
13. Alonso A, Krijthe BP, Aspelund T, Stepas KA, Pencina MJ, Moser CB, Sinner MF, Sotoodehnia N, Fontes JD, Janssens AC, Kronmal RA, Magnani JW, Witteman JC, Chamberlain AM, Lubitz SA, Schnabel RB, Agarwal SK, McManus DD, Ellinor PT, Larson MG, Burke GL, Launer LJ, Hofman A, Levy D, Gottdiener JS, Kääb S, Couper D, Harris TB, Soliman EZ, Stricker BH, Gudnason V, Heckbert SR, Benjamin EJ,: Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: The CHARGE-AF consortium. J Am Heart Assoc 2013; 2: e000102. doi: 10.1161/JAHA.112.000102.
14. Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA,: Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994; 271: 840-844.
15. Benjamin EJ, Chen PS, Bild D E, Mascette AM, Albert CM, Alonso A, Calkins H, Connolly SJ, Curtis AB, Darbar D, Ellinor PT, Go AS, Goldschlager NF, Heckbert SR, Jalife J, Kerr CR, Levy D, Lloyd-Jones DM, Massie BM, Nattel S, Olgin JE, Packer DL, Po SS, Tsang TS, Van Wagoner DR, Waldo AL, Wyse DG,: Prevention of atrial fibrillation: Report from a National Heart, Lung, and Blood Institute workshop. Circulation 2009; 119: 606-618.
16. Borzecki AM, Bridgers DK, Liebschutz JM, Kader B, Kazis LE, Berlowitz DR,: Racial differences in the prevalence of atrial fibrillation among males. J Natl Med Assoc 2008; 100: 237-245.
17. Bush D, Martin LW, Leman R, Chandler M, Haywood LJ,; NHLBI AFFIRM Investigators: Atrial fibrillation among African Americans, Hispanics and Caucasians: Clinical features and outcomes from the AFFIRM trial. J Natl Med Assoc 2006; 98: 330-339.
18. Alonso A, Agarwal SK, Soliman EZ, Ambrose M, Chamberlain AM, Prineas RJ, Folsom AR,: Incidence of atrial fibrillation in whites and African Americans: The Atherosclerosis Risk in Communities (ARIC) study. Am Heart J 2009; 158: 111-117.
19. Marcus GM, Alonso A, Peralta CA, Lettre G, Vittinghoff E, Lubitz SA, Fox ER, Levitzky YS, Mehra R, Kerr KF, Deo R, Sotoodehnia N, Akylbekova M, Ellinor PT, Paltoo DN, Soliman EZ, Benjamin EJ, Heckbert SR,: Candidate-Gene Association Resource (CARe) Study. European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation 2010; 122: 2009-2011.
20. Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, Smith AV, Tarasov KV, Müller M, Sotoodehnia N, Sinner MF, Verwoert GC, Li M, Kao WH, Köttgen A, Coresh J, Bis JC, Psaty BM, Rice K, Rotter JI, Rivadeneira F, Hofman A, Kors JA, Stricker BH, Uitterlinden AG, van Duijn CM, Beckmann BM, Sauter W, Gieger C, Lubitz SA, Newton-Cheh C, Wang TJ, Magnani JW, Schnabel RB, Chung MK, Barnard J, Smith JD, Van Wagoner DR, Vasan RS, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Najjar SS, Lakatta E, Schlessinger D, Uda M, Abecasis GR, Müller-Myhsok B, Ehret GB, Boerwinkle E, Chakravarti A, Soliman EZ, Lunetta KL, Perz S, Wichmann HE, Meitinger T, Levy D, Gudnason V, Ellinor PT, Sanna S, Kääb S, Witteman JC, Alonso A, Benjamin EJ, Heckbert SR,: Genome-wide association study of PR interval. Nat Genet 2010; 42: 153-159.
21. George A Jr,: Inherited disorders of voltage gated sodium channels. J Clin Invest 2005; 115: 1990-1999.
22. Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT,: SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995; 80: 805-811.
23. Rook MB, Bezzina Alshinawi C, Groenewegen WA, van Gelder IC, van Ginneken AC, Jongsma HJ, Mannens MM, Wilde AA,: Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome. Cardiovasc Res 1999; 44: 507-517.
24. Sotoodehnia N, Isaacs A, de Bakker PI, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Köttgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo Leach I, Estrada K, Völker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Völzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, van Veldhuisen DJ, Schwienbacher C, O'Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, te Meerman G, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BH, Samani NJ, Kääb S, Arking DE,: Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 2010; 42: 1068-1076.
25. Jeff JM, Brown-Gentry K, Buxbaum SG, Sarpong DF, Taylor HA, George AL Jr, Roden DM, Crawford DC,: SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study. Circ Cardiovasc Genet 2011; 4: 139-144.
26. Plant LD, Bowers PN, Liu Q, Morgan T, Zhang T, State MW, Chen W, Kittles RA, Goldstein SA,: A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. J Clin Invest 2006; 116: 430-435.
27. Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S, Cherry JM, Snyder M,: Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012; 22: 1790-1797.