Contributions of the pre-bötzinger complex and the kölliker-fuse nuclei to respiratory rhythm and pattern generation in awake and sleeping goats

Progress in Brain Research

Volumn 209, Issue , 2014, Pages 73-89

  Forster, Hubert ^a,b   Bonis, Josh ^a,b   Krause, Katie ^a,b   Wenninger, Julie ^a,b   Neumueller, Suzanne ^a,b   Hodges, Matthew ^a,b   Pan, Lawrence ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MARQUETTE UNIVERSITY   (United States)

Author keywords

Neural plasticity; NREM sleep; Pontine respiratory group; Pre B tzinger complex; Respiratory rhythm and pattern generation; Wakefulness

Indexed keywords

ARECAIDINE; GLUTAMATE RECEPTOR AGONIST; IBOTENIC ACID; NEUROTOXIN;

ABDOMINAL WALL MUSCULATURE; ADULT; ANIMAL TISSUE; APNEA; ARTERIAL GAS; ARTICLE; ARTIFICIAL VENTILATION; BRAIN STEM; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; EXPIRATORY TIME; FACIAL NERVE NUCLEUS; FUNCTIONAL RESIDUAL CAPACITY; GOAT; HISTOLOGY; HYPERCAPNIA; HYPOXEMIA; INSPIRATION TIME; KOLLIKER FUSE NUCLEI; LATERAL PARABRACHIAL NUCLEUS; LUNG VENTILATION; MEDIAL PARABRACHIAL NUCLEUS; MUSCLE CONTRACTION; NERVE CELL PLASTICITY; NONHUMAN; NONREM SLEEP; PARABRACHIAL NUCLEUS; PONTINE NUCLEUS; PRE BOTZINGER COMPLEX; PRIORITY JOURNAL; REM SLEEP; RESPIRATORY NERVE CELL; RESPIRATORY RHYTHM; RESPIRATORY TRACT PARAMETERS; ROSTRAL PON; TACHYPNEA; TIDAL VOLUME; TRACHEOSTOMY; WAKEFULNESS; ANIMAL; DRUG EFFECTS; KOLLIKER FUSE NUCLEUS; PERIODICITY; PHYSIOLOGY; RESPIRATION CENTER; RESPIRATORY FUNCTION; SLEEP;

ANIMALS; GOATS; IBOTENIC ACID; KOLLIKER-FUSE NUCLEUS; NEUROTOXINS; PERIODICITY; RESPIRATORY CENTER; RESPIRATORY PHYSIOLOGICAL PROCESSES; SLEEP; WAKEFULNESS;

EID: 84911922171     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/B978-0-444-63274-6.00005-9     Document Type: Chapter

References (30)

1. Abdala A.P., Rybak I.A., Smith J.C., Zoccal D.B., Machado B.H., St-John W.M., Paton J.F. Multiple pontomedullary mechanisms of respiratory rhythmogenesis. Respir. Physiol. Neurobiol. 2009, 168:19-25.
2. Bisgard G.E., Forster H.V., Klein J.P. Recovery of peripheral chemoreceptor function after denervation in ponies. J. Appl. Physiol. 1980, 49:964-970.
3. Bolser D.C., Poliacek I., Jakus J., Fuller D.D., Davenport P.W. Neurogenesis of cough, other airway defensive behaviors and breathing: a holarchical system?. Respir. Physiol. Neurobiol. 2006, 152:255-265.
4. Bonis J.M., Neumueller S.E., Krause K.L., Kiner T., Smith A., Marshall B.D., Qian B., Pan L.G., Forster H.V. Site-specific effects on respiratory rhythm and pattern of ibotenic acid injections in the pontine respiratory group of goats. J. Appl. Physiol. 2010, 109:171-188.
5. Bonis J.M., Neumueller S.E., Marshall B.D., Krause K.L., Qian B., Pan L.G., Hodges M.R., Forster H.V. The effects of lesions in the dorsolateral pons on the coordination of swallowing and breathing in awake goats. Respir. Physiol. Neurobiol. 2011, 175:272-282.
6. Bonis J.M., Neumueller S.E., Krause K.L., Pan L.G., Hodges M.R., Forster H.V. Contributions of the Kolliker-Fuse nucleus to coordination of breathing and swallowing. Respir. Physiol. Neurobiol. 2013, 189:10-21.
7. Chamberlin N.L. Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing. Respir. Physiol. Neurobiol. 2004, 143:115-125.
8. Chamberlin N.L., Saper C.B. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J. Neurosci. 1994, 14:6500-6510.
9. Dutschmann M., Herbert H. The Kolliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat. Eur. J. Neurosci. 2006, 24:1071-1084.
10. Feldman J.L., Mitchell G.S., Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Annu. Rev. Neurosci. 2003, 26:239-266.
11. Forster H.V. Plasticity in the control of breathing following sensory denervation. J. Appl. Physiol. 2003, 94:784-794.
12. Gray P.A., Janczewski W.A., Mellen N., McCrimmon D.R., Feldman J.L. Normal breathing requires pre-Botzinger complex neurokinin-1 receptor-expressing neurons. Nat. Neurosci. 2001, 4:927-930.
13. Guyenet P.G. The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity. J. Appl. Physiol. 2008, 105:404-416.
14. Krause K.L., Forster H.V., Kiner T., Davis S.E., Bonis J.M., Qian B., Pan L.G. Normal breathing pattern and arterial blood gases in awake and sleeping goats after near total destruction of the presumed pre-Botzinger complex and the surrounding region. J. Appl. Physiol. 2009, 106:605-619.
15. Lumsden T. Observations on the respiratory centres in the cat. J. Physiol. 1923, 57:153-160.
16. McKay L.C., Janczewski W.A., Feldman J.L. Sleep-disordered breathing after targeted ablation of pre-Botzinger complex neurons. Nat. Neurosci. 2005, 8:1142-1144.
17. Michelot D., Melendez-Howell L.M. Amanita muscaria: chemistry, biology, toxicology, and ethnomycology. Mycol. Res. 2003, 107:131-146.
18. Miller J., Neumueller S., Qian B., Hodges M.R., Pan L., Forster H.V. Hypoventilation and reduced CO2 sensitivity with sustained expiratory muscle activity in the awake goat. FASEB J. 2011, 25:847.
19. Mitchell G., Bach K., Martin P., Foley K. Modulation and plasticity of the exercise ventilatory response. Respiration in Health and Disease 1993, 269-277.
20. Mitchell G.S., Bach K.B., Martin P.A., Foley K.T., Olson E.B., Brownfield M.S., Miletic V., Behan M., McGuirk S., Sloan H.E. Increased spinal monoamine concentrations after chronic thoracic dorsal rhizotomy in goats. J. Appl. Physiol. 2000, 89:1266-1274.
21. Neumueller S., Hodges M.R., Krause K., Marshall B., Bonis J., Qian B., Pan L.G., Forster H.V. Anatomic changes in multiple brainstem nuclei after incremental, near-complete neurotoxic destruction of the pre-Botzinger Complex in adult goats. Respir. Physiol. Neurobiol. 2011, 175:1-11.
22. Pan L.G., Forster H.V., Martino P., Strecker P.J., Beales J., Serra A., Lowry T.F., Forster M.M., Forster A.L. Important role of carotid afferents in control of breathing. J. Appl. Physiol. 1998, 85:1299-1306.
23. Ramirez J.M., Schwarzacher S.W., Pierrefiche O., Olivera B.M., Richter D.W. Selective lesioning of the cat pre-Botzinger complex in vivo eliminates breathing but not gasping. J. Physiol. 1998, 507(Pt 3):895-907.
24. Rybak I.A., O'Connor R., Ross A., Shevtsova N.A., Nuding S.C., Segers L.S., Shannon R., Dick T.E., Dunin-Barkowski W.L., Orem J.M., Solomon I.C., Morris K.F., Lindsey B.G. Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments. J. Neurophysiol. 2008, 100:1770-1799.
25. Smith J.C., Ellenberger H.H., Ballanyi K., Richter D.W., Feldman J.L. Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 1991, 254:726-729.
26. Smith J.C., Abdala A.P., Koizumi H., Rybak I.A., Paton J.F. Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. J. Neurophysiol. 2007, 98:3370-3387.
27. St John W.M., Bledsoe T.A. Genesis of rhythmic respiratory activity in pons independent of medulla. J. Appl. Physiol. 1985, 59:684-690.
28. Tan W., Janczewski W.A., Yang P., Shao X.M., Callaway E.M., Feldman J.L. Silencing pre-Botzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat. Neurosci. 2008, 11:538-540.
29. Wenninger J.M., Pan L.G., Klum L., Leekley T., Bastastic J., Hodges M.R., Feroah T., Davis S., Forster H.V. Small reduction of neurokinin-1 receptor-expressing neurons in the pre-Botzinger complex area induces abnormal breathing periods in awake goats. J. Appl. Physiol. 2004, 97:1620-1628.
30. Wenninger J.M., Pan L.G., Klum L., Leekley T., Bastastic J., Hodges M.R., Feroah T.R., Davis S., Forster H.V. Large lesions in the pre-Botzinger complex area eliminate eupneic respiratory rhythm in awake goats. J. Appl. Physiol. 2004, 97:1629-1636.