Important role of carotid afferents in control of breathing

Journal of Applied Physiology

Volumn 85, Issue 4, 1998, Pages 1299-1306

  Pan, L G ^a,b   Forster, H V ^a,c   Martino, P ^a   Strecker, P J ^a   Beales, J ^a   Serra, A ^a   Lowry, T F ^a,c   Forster, M M ^a   Forster, A L ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MARQUETTE UNIVERSITY   (United States)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Breathing; Carotid body denervation; Exercise hyperpnea; Ventilatory carbon dioxide sensitivity

Indexed keywords

CARBON DIOXIDE; SODIUM CYANIDE;

AMBIENT AIR; ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; CAROTID BODY; CONTROLLED STUDY; DENERVATION; FEMALE; GOAT; HUMAN; HYPOVENTILATION; HYPOXIA; MALE; NERVE CELL PLASTICITY; PRIORITY JOURNAL; RESPIRATION CONTROL; SENSORY NERVE; TREADMILL EXERCISE;

EID: 0031694690     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.4.1299     Document Type: Article

References (38)

1. 2 breathing in intact and chemodenervated awake dogs. J. Appl. Physiol. 35: 35-41, 1973.
2. Bisgard, G. E., D. D. Buss, H. V. Forster, J. A. Orr, B. Rasmussen, and C. A. Rawlings. Hypoventilation in ponies after carotid body denervation. J. Appl. Physiol. 40: 184-190 1976.
3. Bisgard, G. E., H. V. Forster, and J. P. Klein. Recovery of peripheral chemoreceptor function after denervation in ponies. J. Appl. Physiol. 49: 964-970, 1980.
4. Bouverot, P., V. Candas, and J. P. Libert. Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits. Respir. Physiol. 17: 209-219, 1973.
5. Brown, D. R., H. V. Forster, A. S. Greene, and T. F. Lowry. Breathing periodicity in intact and carotid body-denervated ponies during normoxia and chronic hypoxia. J. Appl. Physiol. 74: 1073-1082, 1993.
6. Busch, G. E., M. A. Bisgard, H. V. Forster, and J. E. Mesina. The effects of unilateral carotid body excision on ventilatory control in goats. Respir. Physiol. 54: 353-361, 1983.
7. Comroe, J. H., Jr., and C. F. Schmidt. The part played by reflexes from the carotid body in the chemical regulation of respiration in the dog. Am. J. Physiol. 121: 75-97, 1938.
8. Davenport, H. W., G. Brewer, A. H. Chambers, and S. Goldschmidt. The respiratory responses to anoxemia of unanesthetized dogs with chronically denervated aortic and carotid chemoreceptors and their causes. Am. J. Physiol. 148: 406-416, 1947.
9. Dejours, P. Control of respiration by arterial chemoreceptors. Ann. NY Acad. Sci. 109: 682-695, 1963.
10. Dempsey, J. A., and H. V. Forster. Mediation of ventilatory adaptations. Physiol. Rev. 62: 262-346, 1982.
11. + channels essential for carotid chemo-transduction? Respir. Physiol. 110: 211-218, 1997.
12. Dripps, R. D., and J. H. Comroe, Jr. The effect of the inhalation of high and low oxygen concentrations on respiration, pulse rate, ballistocardiogram and arterial oxygen saturation (oximeter) of normal individuals. Am. J. Physiol. 149: 277-291, 1947.
13. Espejo, E. F., R. J. Montoro, J. A. Armengol, and J. Lopez-Barneo. Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron 20: 197-206, 1998.
14. Fencl, V., T. B. Miller, and J. R. Pappenheimer. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning ionic composition of cerebral interstitial fluid. Am. J. Physiol. 210: 459-472, 1966.
15. Fitzgerald, R. S., R. W. B. Penman, J. F. Perkins, Jr., and J. T. Zajtchuk. Ventilatory response to transient perfusion of carotid chemoreceptors. Am. J. Physiol. 207: 1305-1313, 1964.
16. Forster, H. V., G. E. Bisgard, and J. P. Klein. Effect of peripheral chemoreceptor denervation on acclimatization of goats during hypoxia. J. Appl. Physiol. 50: 392-398, 1981.
17. CO2, during exercise in humans. J. Appl. Physiol. 75: 1385-1394, 1993.
18. Forster, H. V., P. J. Ohtake, L. G. Pan, and T. F. Lowry. Effect on breathing of surface ventrolateral medullary cooling in awake, anesthetized and asleep goats. Respir. Physiol. 110: 187-197, 1997.
19. Gautier, H., and M. Bonora. Effect of carotid body denervation on respiratory pattern of awake cats. J. Appl. Physiol. 46: 1127-1131, 1979.
20. Gemmill, C. L., and D. L. Reeves. The effect of anoxemia in normal dogs before and after denervation of the carotid sinuses. Am. J. Physiol. 105: 487-495, 1933.
21. Honda, Y., S. Myojo, S. Hasegawa, T. Hawegawa, and J. W. Severinghaus. Decreased exercise hyperpnea in patients with bilateral carotid chemoreceptor resection. J. Appl. Physiol. 46: 908-912, 1979.
22. Hoop, B., M.-R. Masjedi, V. E. Shih, and H. Kazemi. Brain glutamate metabolism during hypoxia and peripheral chemodenervation. J. Appl. Physiol. 69: 147-154, 1990.
23. Horn, E. M., and T. G. Waldrop. Oxygen-sensing neurons in the caudal hypothalamus and their role in cardiorespiratory control. Respir. Physiol. 110: 219-228, 1997.
24. Jiang, C., and G. G. Haddad. A direct mechanism for sensing low oxygen levels by central neurons. Proc. Natl. Acad. Sci. USA 91: 7198-7201, 1994.
25. Katsaros, B. Evidence for the existence of a respiratory drive of unknown origin conducted in the carotid sinus nerves. In: Arterial Chemoreceptors, edited by R. W. Torrance. Oxford, UK: Blackwell Scientific, 1968, p. 357-372.
26. Kaufman, M. P., and H. V. Forster. Reflexes controlling circulatory, ventilatory, and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, pt. II, chapt. 10, p. 381-447.
27. Lahiri, S., N. H. Edelman, N. S. Cherniack, and A. P. Fishman. Role of carotid chemoreflex in respiratory acclimatization to hypoxemia in goat and sheep. Respir. Physiol. 46: 367-382: 1981.
28. Mitchell, R. A. Cerebrospinal fluid and the regulation of respiration. In: Advances in Respiratory Physiology, edited by C. G. Caro. Baltimore, MD: Williams & Wilkins, 1966, p. 1-47.
29. 2 sensitivity. J. Appl. Physiol. 65: 1525-1534, 1988.
30. Pan, L. G., H. V. Forster, G. E. Bisgard, R. P. Kaminski, S. M. Dorsey, and. M. A. Busch. Hyperventilation in ponies at the onset of and during steady-state exercise. J. Appl. Physiol. 54: 1394-1402, 1983.
31. Pan, L. G., H. V. Forster, P. J. Ohtake, T. F. Lowry, M. J. Korducki, and A. L. Forster. Effect of carotid chemoreceptor denervation on breathing during ventrolateral medullary cooling in goats. J. Appl. Physiol. 79: 1120-1128, 1995.
32. Perkins, J. F. The contribution of the peripheral respiratory chemoreceptors to pulmonary ventilation - a historical and experimental aproach. In: Arterial Chemoreceptors, edited by R. W. Torrance. Oxford, UK: Blackwell Scientific, 1968, p. 335-356.
33. Schlaefke, M. E., J. F. Kelle, and H. H. Loeschcke. Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats. Pflügers Arch. 378: 231-234, 1979.
34. Smith, C. A., G. E. Bisgard, A. M. Nielsen, L. Daristotle, N. A. Kressin, H. V. Forster, and J. A. Dempsey. Carotid bodies are required for ventilatory acclimatization to chronic hypoxia. J. Appl. Physiol. 60: 1003-1010, 1986.
35. Smith, C. A., K. W. Saupe, K. S. Henderson, and J. A. Dempsey. Ventilatory effects of specific carotid body hypocapnia in dogs during wakfulness and sleep. J. Appl. Physiol. 79: 689-699, 1995.
36. Tenney, S. M., and J. G. Brooks III. Carotid bodies, stimulus interaction, and ventilatory control in unanesthetized goats. Respir. Physiol. 1: 211-224, 1966.
37. Wasserman, K., B. J. Whipp, S. N. Kozal, and M. G. Cleary. Effect of carotid body resection in ventilatory and acid-base control during exercise. J. Appl. Physiol. 39: 354-358, 1975.
38. Watt, J. G., P. R. Dumke, and J. H. Comroe, Jr. Effects of inhalation of 100 per cent and 14 per cent oxygen upon respiration of unanesthetized dogs before and after chemoreceptor denervation. Am. J. Physiol. 138: 610-617, 1942.