Large lesions in the pre-Bötzinger complex area eliminate eupneic respiratory rhythm in awake goats

Journal of Applied Physiology

Volumn 97, Issue 5, 2004, Pages 1629-1636

  Wenninger, J M ^b   Pan, L G ^b   Klum, L ^b   Leekley, T ^b   Bastastic, J ^b   Hodges, M R ^b   Feroah, T R ^b   Davis, S ^b   Forster, H V ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NONE

Author keywords

Inspiratory and preinspiratory neurons; Respiratory rhythm generator; Terminal apnea

Indexed keywords

IBOTENIC ACID;

ABDOMINAL WALL MUSCULATURE; AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; DIAPHRAGM MOVEMENT; FEMALE; HEART ARREST; HYPERCAPNIA; HYPERPNEA; HYPOXEMIA; MALE; MUSCLE CONTRACTION; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; RESPIRATORY FAILURE; TACHYPNEA; VENTILATOR;

ANIMALS; DIAPHRAGM; FEMALE; GOATS; IBOTENIC ACID; INHALATION; MALE; MEDULLA OBLONGATA; PERIODICITY; RESPIRATION; RESPIRATION DISORDERS; RESPIRATORY MUSCLES; WAKEFULNESS;

EID: 7044227823     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00953.2003     Document Type: Article

References (26)

1. Chitravanshi VC and Sapru HN. Phrenic nerve responses to chemical stimulation of the subregions of ventral medullary respiratory neuronal group in the rat. Brain Res 821: 443-460, 1999.
2. Chuang DM, Gao XM, and Paul SM. NMDA exposure blocks glutamate toxicity in cultured cerebellar granule cells. Mol Pharmacol 42: 210-216, 1992.
3. Cotran RS, Kumar V, and Collins T. Pathologic Basis of Disease (6th ed.). Philadelphia, PA: Saunders, 1999, p. 1295.
4. Feldman JL, Mitchell GS, and Nattie EE. Breathing: rhythmicity, plasticity chemosensitivity. Annu Rev Neurosci 26: 239-266, 2003.
5. Forster HV, Pan LG, Lowry TF, Feroah T, Gershan GM, Whaley AA, Forster MM, and Sprtel B. Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons. J Appl Physiol 84: 129-140, 1998.
6. Gray PA, Janczewski WA, Mellen N, McCrimmon DR, and Feldman JL. Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4: 927-930, 2001.
7. Hsich JH, Chang YC, Su CK, Hwang JC, Yen CT, and Chai CY. A single minute lesion around the ventral respiratory group in medulla produces fatal apnea in cats. J Auton Nerv Syst 73: 7-18, 1998.
8. Janczewski WA, Onimaru H, Homma I, and Feldman JL. Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J Physiol 545: 1017-1026, 2002.
9. Johnson SM, Koshiya N, and Smith JC. Isolation of the kernel for respiratory rhythm generation in a novel preparation: the pre-Bötzinger complex "island". J Neurophysiol 85: 1772-1776, 2001.
10. Koshiya N and Guyenet PG. Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat. J Physiol 491: 859-869, 1996.
11. Lieske SP, Thoby-Brisson M, Telgkamp P, and Ramirez JM. Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, signs, and gasps. Nature Neuroscience 3: 600-607, 2000.
12. Lumsden T. Observations on the respiratory centers. J Physiol 57: 153-160, 1923.
13. Lumsden T. The regulation of respiration I. J Physiol 58: 81-91, 1923.
14. Mellen NM, Janczewski WA, Bocchiaro CM, and Feldman JL. Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron 37: 821-826, 2003.
15. Monnier A, Alheid GF, and McCrimmon DR. Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat. J Physiol 548: 859-874, 2003.
16. 2 sensitivity. J Appl Physiol 65: 1525-1534, 1988.
17. Onimaru H and Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J Neurosci 23: 1478-1486, 2003.
18. Ramirez JM, Schwarzacher SW, Pierrefiche O, Olivera BM, and Richter DW. Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping. J Physiol 15: 895-907, 1998.
19. Rekling JC and Feldman JL. Pre-Bötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol 60: 385-405, 1998.
20. Smith JC, Butera RJ Jr, Koshiya N, Del Negro C, Wilson CG, and Johnson SM. Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respir Physiol 122: 131-147, 2000.
21. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.
22. Solomon IC, Edelman NH, and Neubauer JA. Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo. J Neurophysiol 81: 1150-1161, 1999.
23. St. Jacques R and St. John WM. Transient, reversible apnoea following ablation of the pre-Bötzinger complex in rats. J Physiol 520: 303-314, 1999.
24. St. John WM. Rostral medullary respiratory neuronal activities of decerebrate cats in eupnea, apneusis, and gasping. Respir Physiol 116: 47-65, 1999.
25. St. John WM. Medullary regions for neurogenesis of gasping: noeud vital or noeuds vitals? J Appl Physiol 81: 1865-1877, 1996.
26. Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah T, Davis S, and Forster HV. Small reduction of neurokinin-1 receptor-expressing neurons in the pre-Bötzinger complex area induces abnormal breathing periods in awake goats. J Appl Physiol 97: 1620-1628, 2004.