Anatomic changes in multiple brainstem nuclei after incremental, near-complete neurotoxic destruction of the pre-Bötzinger Complex in adult goats

Respiratory Physiology and Neurobiology

Volumn 175, Issue 1, 2011, Pages 1-11

  Neumueller, S ^a   Hodges, M R ^a   Krause, K ^a   Marshall, B ^a   Bonis, J ^a   Qian, B ^a   Pan, L G ^b   Forster, H V ^a,c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MARQUETTE UNIVERSITY   (United States)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Facial nucleus; Neurogenesis; Parafacial; Plasticity; PreB tC; Retrotrapezoid nucleus

Indexed keywords

AMBIGUUS NUCLEUS; ANATOMICAL VARIATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN REGION; BRAIN STEM; BREATHING; CELL COUNT; CELL DENSITY; CONTROLLED STUDY; FACIAL NERVE NUCLEUS; GOAT; HYPOGLOSSAL NUCLEUS; MEDULLA OBLONGATA; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOLOGICAL ANATOMY; PONS ANGLE; PRE BOTZINGER COMPLEX; PRIORITY JOURNAL; RAPHE NUCLEUS; RESPIRATORY NERVE CELL; VAGUS NERVE NUCLEUS;

ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; CELL NUCLEUS; GOATS; IBOTENIC ACID; MEDULLA OBLONGATA; NERVE NET; NEURONS; NEUROTOXINS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PHOSPHOPYRUVATE HYDRATASE; RECEPTOR, MUSCARINIC M1; RECEPTORS, NEUROKININ-1; RESPIRATORY CENTER; TIME FACTORS; WAKEFULNESS;

EID: 78650169045     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.06.010     Document Type: Article

References (28)

1. Alheid G.F., Gray P.A., Jiang M.C., Feldman J.L., McCrimmon D.R. Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat. J. Neurocytol. 2002, 31:693-717.
2. Altman J., Das G. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 1965, 123:319-335.
3. Bauer S., Hay M., Amilhon B., Jean A., Moyse E. In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem. Neuroscience 2005, 130:75-90.
4. Bonfanti L., Ponti G. Adult mammalian neurogenesis and the New Zealand white rabbit. Vet. J. 2008, 175:310-331.
5. Bonis J., Neumueller S., Krause K., Kiner T., Smith A., Marshall B., Qian B., Pan L., Forster H. The pontine respiratory group, particularly the Köllifer-Fuse nucleus mediates phases of the hypoxic ventilatory response in unanesthetized goats. J. Appl. Physiol. 2010, (PCMID 20167677).
6. Cameron H., McKay R. Adult neurogenesis produces a large pool of new granule cells in the dentante gyrus. J. Comp. Neurol. 2001, 435:406-417.
7. Czaja K., Burns G., Ritter R. Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats. Neuroscience 2008, 154:621-630.
8. Dean C., Geiger L.K., Sprtel B.M., Ohtake P.J., Forster H.V. An anatomic atlas of the medulla oblongata of the adult goat. J. Appl. Physiol. 1999, 87:1220-1229.
9. Fortuna M.G., West G.H., Stornetta R.L., Guyenet P.G. Botzinger expiratory-augmenting neurons and the parafacial respiratory group. J. Neurosci. 2008, 28:2506-2515.
10. Gray P.A., Rekling J.C., Bocchiaro C.M., Feldman J.L. Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex. Science 1999, 286:1566-1568.
11. 2 sensitivity after neurotoxic lesions in the medullary raphe area of awake goats. J. Appl. Physiol. 2004, 97:2236-2247.
12. Krause K.L., Forster H.V., Davis S.E., Kiner T., Bonis J.M., Pan L.G., Qian B. Focal acidosis in the pre-Botzinger complex area of awake goats induces a mild tachypnea. J. Appl. Physiol. 2009, 106:241-250.
13. Krause K.L., Forster H.V., Kiner T., Davis S.E., Bonis J.M., Qian B., Pan L.G. Normal breathing pattern and arterial blood gases in awake and sleeping goats after near total destruction of the presumed pre-Botzinger complex and the surrounding region. J. Appl. Physiol. 2009, 106:605-619.
14. Levison S., Goldman J. Both oligodendrocytes and astrocytes develop from progen itors in the subventricular zone of postnatal rat forebrain. Neuron 1993, 10:201-212.
15. Lumsden T. Observations on the respiratory centres. J. Physiol. 1923, 57:354-367.
16. McCrimmon D.R., Monnier A., Hayashi F., Zuperku E.J. Pattern formation and rhythm generation in the ventral respiratory group. Clin. Exp. Pharmacol. Physiol. 2000, 27:126-131.
17. Onimaru H., Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J. Neurosci. 2003, 23:1478-1486.
18. Smith J.C., Abdala A.P., Rybak I.A., Paton J.F. Structural and functional architecture of respiratory networks in the mammalian brainstem. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2577-2587.
19. Smith J.C., Ellenberger H.H., Ballanyi K., Richter D.W., Feldman J.L. Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 1991, 254:726-729.
20. Solomon I.C., Edelman N.H., Neubauer J.A. Pre-Botzinger complex functions as a central hypoxia chemosensor for respiration in vivo. J. Neurophysiol. 2000, 83:2854-2868.
21. St John W.M., Bledsoe T.A. Genesis of rhythmic respiratory activity in pons independent of medulla. J. Appl. Physiol. 1985, 59:684-690.
22. Stornetta R.L., Rosin D.L., Wang H., Sevigny C.P., Weston M.C., Guyenet P.G. A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Botzinger complex. J. Comp. Neurol. 2003, 455:499-512.
23. Takakura A.C., Moreira T.S., Stornetta R.L., West G.H., Gwilt J.M., Guyenet P.G. Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats. J. Physiol. 2008, 586:2975-2991.
24. Tan W., Janczewski W.A., Yang P., Shao X.M., Callaway E.M., Feldman J.L. Silencing preBotzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat. Neurosci. 2008, 11:538-540.
25. Wang Y., Jin K., Mao X., Xie L., Banwait S., Marti H., Breenberg D. VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. J. Neurosci. Res. 2007, 85:740-747.
26. Wenninger J.M., Pan L.G., Klum L., Leekley T., Bastastic J., Hodges M.R., Feroah T., Davis S., Forster H.V. Small reduction of neurokinin-1 receptor-expressing neurons in the pre-Botzinger complex area induces abnormal breathing periods in awake goats. J. Appl. Physiol. 2004, 97:1620-1628.
27. Wenninger J.M., Pan L.G., Klum L., Leekley T., Bastastic J., Hodges M.R., Feroah T.R., Davis S., Forster H.V. Large lesions in the pre-Botzinger complex area eliminate eupneic respiratory rhythm in awake goats. J. Appl. Physiol. 2004, 97:1629-1636.
28. Wenninger J.M., Pan L.G., Martino P., Geiger L., Hodges M., Serra A., Feroah T.R., Forster H.V. Multiple rostral medullary nuclei can influence breathing in awake goats. J. Appl. Physiol. 2001, 91:777-788.