-
1
-
-
11144315998
-
Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
-
Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, et al. (2004) Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306: 2261-2264.
-
(2004)
Science
, vol.306
, pp. 2261-2264
-
-
Gershengorn, M.C.1
Hardikar, A.A.2
Wei, C.3
Geras-Raaka, E.4
Marcus-Samuels, B.5
-
2
-
-
11144283080
-
Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue
-
Lechner A, Nolan AL, Blacken RA, Habener JF (2005) Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 327: 581-588.
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 581-588
-
-
Lechner, A.1
Nolan, A.L.2
Blacken, R.A.3
Habener, J.F.4
-
3
-
-
31444455909
-
Expansion and redifferentiation of adult human pancreatic islet cells
-
Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, et al. (2006) Expansion and redifferentiation of adult human pancreatic islet cells. Biochem Biophys Res Commun 341: 291-298.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 291-298
-
-
Ouziel-Yahalom, L.1
Zalzman, M.2
Anker-Kitai, L.3
Knoller, S.4
Bar, Y.5
-
4
-
-
44749087001
-
In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing
-
Russ HA, Bar Y, Ravassard P, Efrat S (2008) In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes 57: 1575-1583.
-
(2008)
Diabetes
, vol.57
, pp. 1575-1583
-
-
Russ, H.A.1
Bar, Y.2
Ravassard, P.3
Efrat, S.4
-
5
-
-
68149156892
-
Epithelialmesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells
-
Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S (2009) Epithelialmesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One 4: e6417.
-
(2009)
PLoS One
, vol.4
, pp. e6417
-
-
Russ, H.A.1
Ravassard, P.2
Kerr-Conte, J.3
Pattou, F.4
Efrat, S.5
-
6
-
-
79959992876
-
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
-
Bar-Nur O, Russ HA, Efrat S, Benvenisty N (2011) Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9: 17-23.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 17-23
-
-
Bar-Nur, O.1
Russ, H.A.2
Efrat, S.3
Benvenisty, N.4
-
7
-
-
80053608936
-
Insulinproducing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
-
Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, et al. (2011) Insulinproducing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One 6: e25566.
-
(2011)
PLoS One
, vol.6
, pp. e25566
-
-
Russ, H.A.1
Sintov, E.2
Anker-Kitai, L.3
Friedman, O.4
Lenz, A.5
-
8
-
-
52749088737
-
HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro
-
Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S (2008) HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes 57: 2413-2420.
-
(2008)
Diabetes
, vol.57
, pp. 2413-2420
-
-
Bar, Y.1
Russ, H.A.2
Knoller, S.3
Ouziel-Yahalom, L.4
Efrat, S.5
-
9
-
-
84861216975
-
Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway
-
Bar Y, Russ HA, Sintov E, Anker-Kitai L, Knoller S, et al. (2012) Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem 287: 17269-17280.
-
(2012)
J Biol Chem
, vol.287
, pp. 17269-17280
-
-
Bar, Y.1
Russ, H.A.2
Sintov, E.3
Anker-Kitai, L.4
Knoller, S.5
-
11
-
-
0035991907
-
Plasma membrane components of adherens junctions (Review)
-
Blaschuk OW, Rowlands TM (2002) Plasma membrane components of adherens junctions (Review). Mol Membr Biol 19: 75-80.
-
(2002)
Mol Membr Biol
, vol.19
, pp. 75-80
-
-
Blaschuk, O.W.1
Rowlands, T.M.2
-
12
-
-
84862171364
-
The many faces and functions of betacatenin
-
Valenta T, Hausmann G, Basler K (2012) The many faces and functions of betacatenin. EMBO J 31: 2714-2736.
-
(2012)
EMBO J
, vol.31
, pp. 2714-2736
-
-
Valenta, T.1
Hausmann, G.2
Basler, K.3
-
13
-
-
84873681862
-
The way Wnt works: Components and mechanism
-
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, et al. (2013) The way Wnt works: components and mechanism. Growth Factors 31: 1-31.
-
(2013)
Growth Factors
, vol.31
, pp. 1-31
-
-
Saito-Diaz, K.1
Chen, T.W.2
Wang, X.3
Thorne, C.A.4
Wallace, H.A.5
-
14
-
-
24944487996
-
Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
-
Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A (2005) Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 15: 1677-1683.
-
(2005)
Curr Biol
, vol.15
, pp. 1677-1683
-
-
Dessimoz, J.1
Bonnard, C.2
Huelsken, J.3
Grapin-Botton, A.4
-
15
-
-
33745084564
-
Stabilization of beta-catenin impacts pancreas growth
-
Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M (2006) Stabilization of beta-catenin impacts pancreas growth. Development 133: 2023-2032.
-
(2006)
Development
, vol.133
, pp. 2023-2032
-
-
Heiser, P.W.1
Lau, J.2
Taketo, M.M.3
Herrera, P.L.4
Hebrok, M.5
-
16
-
-
28044449357
-
Beta-catenin is essential for pancreatic acinar but not islet development
-
Murtaugh LC, Law AC, Dor Y, Melton DA (2005) Beta-catenin is essential for pancreatic acinar but not islet development. Development 132: 4663-4674.
-
(2005)
Development
, vol.132
, pp. 4663-4674
-
-
Murtaugh, L.C.1
Law, A.C.2
Dor, Y.3
Melton, D.A.4
-
17
-
-
25844530871
-
Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
-
Papadopoulou S, Edlund H (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54: 2844-2851.
-
(2005)
Diabetes
, vol.54
, pp. 2844-2851
-
-
Papadopoulou, S.1
Edlund, H.2
-
18
-
-
34547516561
-
Wnt signaling regulates pancreatic beta cell proliferation
-
Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, et al. (2007) Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A 104: 6247-6252.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6247-6252
-
-
Rulifson, I.C.1
Karnik, S.K.2
Heiser, P.W.3
Ten Berge, D.4
Chen, H.5
-
19
-
-
36649015410
-
Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules
-
Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51: 147-154.
-
(2008)
Diabetologia
, vol.51
, pp. 147-154
-
-
Schinner, S.1
Ulgen, F.2
Papewalis, C.3
Schott, M.4
Woelk, A.5
-
20
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512.
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
Sparks, A.B.2
Rago, C.3
Hermeking, H.4
Zawel, L.5
-
21
-
-
0033545845
-
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
-
Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, et al. (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 96: 5522-5527.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 5522-5527
-
-
Shtutman, M.1
Zhurinsky, J.2
Simcha, I.3
Albanese, C.4
D'Amico, M.5
-
22
-
-
80053345327
-
CMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication
-
Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, et al. (2011) cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol 25: 1760-1772.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1760-1772
-
-
Karslioglu, E.1
Kleinberger, J.W.2
Salim, F.G.3
Cox, A.E.4
Takane, K.K.5
-
23
-
-
17644387563
-
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
-
Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, et al. (2005) Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 25: 3752-3762.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3752-3762
-
-
Kushner, J.A.1
Ciemerych, M.A.2
Sicinska, E.3
Wartschow, L.M.4
Teta, M.5
-
24
-
-
62749083679
-
Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis cell cycle progression, and proliferation in human islets
-
Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, et al. (2009) Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 58: 663-672.
-
(2009)
Diabetes
, vol.58
, pp. 663-672
-
-
Liu, H.1
Remedi, M.S.2
Pappan, K.L.3
Kwon, G.4
Rohatgi, N.5
-
25
-
-
24144497139
-
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells
-
Dihlmann S, Kloor M, Fallsehr C, von Knebel Doeberitz M (2005) Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 26: 1503-1512.
-
(2005)
Carcinogenesis
, vol.26
, pp. 1503-1512
-
-
Dihlmann, S.1
Kloor, M.2
Fallsehr, C.3
Von Knebel Doeberitz, M.4
-
26
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
-
27
-
-
27744518040
-
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
-
Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, et al. (2005) FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2: 153-163.
-
(2005)
Cell Metab
, vol.2
, pp. 153-163
-
-
Kitamura, Y.I.1
Kitamura, T.2
Kruse, J.P.3
Raum, J.C.4
Stein, R.5
-
28
-
-
41649105534
-
Wnt/Notch signalling and information processing during development
-
Hayward P, Kalmar T, Arias AM (2008) Wnt/Notch signalling and information processing during development. Development 135: 411-424.
-
(2008)
Development
, vol.135
, pp. 411-424
-
-
Hayward, P.1
Kalmar, T.2
Arias, A.M.3
-
29
-
-
84887212494
-
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: Evidence for an intersection between beta-catenin pools
-
Kam Y, Quaranta V (2009) Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One 4: e4580.
-
(2009)
PLoS One
, vol.4
, pp. e4580
-
-
Kam, Y.1
Quaranta, V.2
-
30
-
-
0035836706
-
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3
-
Gartel AL, Ye X, Goufman E, Shianov P, Hay N, et al. (2001) Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A 98: 4510-4515.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4510-4515
-
-
Gartel, A.L.1
Ye, X.2
Goufman, E.3
Shianov, P.4
Hay, N.5
-
31
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241-250.
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
Sancho, E.2
Verweij, C.3
De Lau, W.4
Oving, I.5
-
32
-
-
0035967099
-
Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc
-
Yang W, Shen J, Wu M, Arsura M, FitzGerald M, et al. (2001) Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene 20: 1688-1702.
-
(2001)
Oncogene
, vol.20
, pp. 1688-1702
-
-
Yang, W.1
Shen, J.2
Wu, M.3
Arsura, M.4
Fitzgerald, M.5
-
33
-
-
84866389264
-
Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
-
Talchai C, Xuan S, Lin HV, Sussel L, Accili D (2012) Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150: 1223-1234.
-
(2012)
Cell
, vol.150
, pp. 1223-1234
-
-
Talchai, C.1
Xuan, S.2
Lin, H.V.3
Sussel, L.4
Accili, D.5
-
34
-
-
84863174924
-
FoxO1 as a double-edged sword in the pancreas: Analysis of pancreas- and betacell- specific FoxO1 knockout mice
-
Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, et al. (2012) FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and betacell- specific FoxO1 knockout mice. Am J Physiol Endocrinol Metab 302: E603- 613.
-
(2012)
Am J Physiol Endocrinol Metab 302: E603- 613
-
-
Kobayashi, M.1
Kikuchi, O.2
Sasaki, T.3
Kim, H.J.4
Yokota-Hashimoto, H.5
-
35
-
-
0034643331
-
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
-
Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404: 782-787.
-
(2000)
Nature
, vol.404
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.2
Bos, J.L.3
Burgering, B.M.4
-
36
-
-
33845523340
-
Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes
-
Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, et al. (2006) Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55: 3238-3245.
-
(2006)
Diabetes
, vol.55
, pp. 3238-3245
-
-
Sherry, N.A.1
Kushner, J.A.2
Glandt, M.3
Kitamura, T.4
Brillantes, A.M.5
-
37
-
-
84900330718
-
Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy
-
Wang Z, York NW, Nichols CG, Remedi MS (2014) Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab 19: 872-882.
-
(2014)
Cell Metab
, vol.19
, pp. 872-882
-
-
Wang, Z.1
York, N.W.2
Nichols, C.G.3
Remedi, M.S.4
-
38
-
-
84891856422
-
Expression of mesenchymal and alpha-cell phenotypic markers in islet beta-cells in recently diagnosed diabetes
-
White MG, Marshall HL, Rigby R, Huang GC, Amer A, et al. (2013) Expression of mesenchymal and alpha-cell phenotypic markers in islet beta-cells in recently diagnosed diabetes. Diabetes Care 36: 3818-3820.
-
(2013)
Diabetes Care
, vol.36
, pp. 3818-3820
-
-
White, M.G.1
Marshall, H.L.2
Rigby, R.3
Huang, G.C.4
Amer, A.5
|