Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells

International Immunopharmacology

Volumn 24, Issue 1, 2015, Pages 1-6

  Eo, Hyun Ji ^a   Park, Gwang Hun ^a   Song, Hun Min ^a   Lee, Jin Wook ^a   Kim, Mi Kyoung ^a   Lee, Man Hyo ^b   Lee, Jeong Rak ^b   Koo, Jin Suk ^a   Jeong, Jin Boo ^a  

^a Andong National University   (South Korea)

^b Gyeongbuk Institute for Bio industry   (South Korea)

Author keywords

Cancer chemoprevention; Cell growth; Cyclin D1; Human colorectal cancer; Silymarin

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN D1; MESSENGER RNA; SILYMARIN; THREONINE; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUPEPTIN; NITRILE; PROTEASOME; SULFONE;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG HALF LIFE; DRUG MECHANISM; HCT116 CELL LINE; HUMAN; HUMAN CELL; POINT MUTATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ANTAGONISTS AND INHIBITORS; CELL CYCLE; COLORECTAL TUMOR; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; SILYBUM MARIANUM;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIN D1; HCT116 CELLS; HUMANS; LEUPEPTINS; MILK THISTLE; NF-KAPPA B; NITRILES; PHOSPHORYLATION; POINT MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SILYMARIN; SULFONES; THREONINE;

EID: 84911911751     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.11.009     Document Type: Article

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