Characterization of cellular immune response and innate immune signaling in human and nonhuman primate primary mononuclear cells exposed to Burkholderia mallei

Microbial Pathogenesis

Volumn 78, Issue , 2015, Pages 20-28

  Alam, Shahabuddin ^a   Amemiya, Kei ^a   Bernhards, Robert C ^a   Ulrich, Robert G ^a   Waag, David M ^a   Saikh, Kamal U ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Burkholderia mallei; Burkholderia pseudomallei; Cytokines; Glanders; Immune pathogenesis; Inflammation; Melioidosis; MyD88

Indexed keywords

ANTIINFECTIVE AGENT; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIGAND; MYELOID DIFFERENTIATION FACTOR 88; MYELOID DIFFERENTIATION FACTOR 88 INHIBITOR; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BURKHOLDERIA MALLEI; BURKHOLDERIA PSEUDOMALLEI; CELL ASSAY; CELLULAR IMMUNITY; CHLOROCEBUS AETHIOPS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG MECHANISM; DRUG TARGETING; GLANDERS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPATHOGENESIS; INFLAMMATION; INNATE IMMUNITY; MACACA FASCICULARIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN FUNCTION; RHESUS MONKEY; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; GENETICS; IMMUNOLOGY; MICROBIOLOGY; MONONUCLEAR CELL; PHYSIOLOGY;

BURKHOLDERIA MALLEI; BURKHOLDERIA PSEUDOMALLEI; PRIMATES;

ANIMALS; BURKHOLDERIA MALLEI; CERCOPITHECUS AETHIOPS; CYTOKINES; DISEASE MODELS, ANIMAL; GLANDERS; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; MACACA FASCICULARIS; MACACA MULATTA;

EID: 84911886645     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2014.11.009     Document Type: Article

References (30)

1. Gilad J., Harary I., Dushnitsky T., Schwartz D., Amsalem Y. Burkholderia mallei and Burkholderia pseudomallei as bioterrorism agents: national aspects of emergency preparedness. Isr. Med. Assoc. J. 2007, 9:499-503.
2. Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E., Feldblyum T., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C., Davidsen T.D., Deboy R.T., Dimitrov G., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Khouri H., Kolonay J.F., Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M. Structural flexibility in the Burkholderia mallei genome. Proc . Natl. Acad. Sci. U. S. A. 2004, 101:14246-14251.
3. Howe C., Sampath A., Spotnitz M. The pseudomallei group: a review. J.Infect. Dis. 1971, 124:598-606.
4. Currie B.J., Fisher D.A., Howard D.M., Burrow J.N.C., Lo D., Selva-nayagam S., Anstey N.M., Huffam S.E., Snelling P.L., Marks P.J., Stephens D.P., Lum G.D., Jacups S.P., Krause V.L. Endemic melioidosis in tropical Northern Australia: a 10-Year prospective: study and review of the literature. Clin. Infect. Dis. 2000, 31:981-986.
5. Howe C., Miller W.R. Human glanders; report of six cases. Ann. Intern. Med. 1947, 26:93-115.
6. Srinivasan A.1, Kraus C.N., DeShazer D., Becker P.M., Dick J.D., Spacek L., Bartlett J.G., Byrne W.R., Thomas D.L. Glanders in a military research microbiologist. N.Engl. J. Med. 2001, 345:256-258.
7. Dvorak G.D., Spickler A.R. Glanders. J.Am. Vet. Med. Assoc. 2008, 233:570-577.
8. Jeddeloh J.A.1, Fritz D.L., Waag D.M., Hartings J.M., Andrews G.P. Biodefense-driven murine model of pneumonic melioidosis. Infect. Immun. 2003, 71:584-587.
9. Rotz L.D., Khan A.S., Lillibridge S.R., Ostroff S.M., Hughes J.M. Public health assessment of potential biological terrorism agents. Emerg. Infect. Dis. 2002, 8:225-230.
10. White N.J. Melioidosis. Lancet 2003, 361:1715-1722.
11. Currie B.J.1, Fisher D.A., Howard D.M., Burrow J.N., Selvanayagam S., Snelling P.L., Anstey N.M., Mayo M.J. The epidemiology of meliodosis in Australia and Papua New Guinea. Acta Trop. 2000, 74:121-127.
12. Friedland J.S., Suputtamongkol Y., Remick D.G., Chaowagul W., Strieter R.M., Kunkel S.L., White N.J., Griffin G.E. Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection. Infect. Immun. 1992, 60:2402-2408.
13. Lauw F.N., Simpson A.J., Prins J.M., Smith M.D., Kurimoto M., van Deventer S.J., Speelman P., Chaowagul W., White N.J., van der Poll T. Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. J.Infect. Dis. 1999, 180:1878-1885.
14. Lauw F.N., Simpson A.J., Prins J.M., van Deventer S.J., Chaowagul W., White N.J., van der Poll T. The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. Infect. Immun. 2000, 68:3888-3893.
15. Smith M.D., Suputtamongkol Y., Chaowagul W., Assicot M., Bohuon C., Petitjean S., White N.J. Elevated serum procalcitonin levels in patients with melioidosis. Clin. Infect. Dis. 1995, 20(3):641-645.
16. Liu B., Koo G.C., Yap E.H., Chua K.L., Gan Y.H. Model of differential susceptibility to mucosal Burkholderia pseudomallei infection. Infect. Immun. 2002, 70:504-511.
17. Ulett G.C., Ketheesan N., Hirst R.G. Cytokine gene expression in innately susceptible BALB/c mice and relatively resistant C57BL/6 mice during infection with virulent Burkholderia pseudomallei. Infect. Immun. 2000, 68:2034-2042.
18. Kawai T., Adachi O., Ogawa T., Takeda K., Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999, 11:115-122.
19. Kissner T.L., Cisney E.D., Ulrich R.G., Fernandez S., Saikh K.U. Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88. Immunology 2010, 130:516-526.
20. Kissner T.L., Ruthel G., Cisney E.D., Ulrich R.G., Fernandez S., Saikh K.U. MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice. Innate Immune 2011, 17:451-462.
21. Amemiya K., Meyers J.L., Deshazer D., Riggins R.N., Halasohoris S., England M., Ribot W., Norris S.L., Waag D.M. Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice. Diagn. Microbiol. Infect. Dis. 2007, 59:137-147.
22. Amemiya K., Bush G.V., DeShazer D., Waag D.M. Nonviable Burkholderia mallei induces a mixed Th1- and Th2-like cytokine response in BALB/c mice. Infect. Immun. 2002, 70:2319-2325.
23. Yi E.C., Hackett M. Rapid isolation method for lipopolysaccharide and lipid A from gram-negative bacteria. Analyst 2000, 125:651-656.
24. Kissner T.L., Moisan L., Mann E., Ulrich R.G., Ping S., Waugh D., Rebek M., Rebek J., Saikh K.U. Asmall molecule that mimics the BB-loop in Toll/IL-1 receptor domain of MyD88 attenuate staphylococcal enterotoxin induced cytokine production and toxic shock in mice. J.Biol. Chem. 2011, 286:31385-31396.
25. Kissner T.L., Ruthel G., Alam S., Mann E., Ajami D., Rebek M., Larkin E., Fernandez S., Ulrich R.G., Ping S., Waugh D.S., Rebek J., Saikh K.U. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One 2012, 7:e40773.
26. Yeager J.J., Facemire P., Dabisch P.A., Robinson C.G., Nyakiti D., Beck K., Baker R., Pitt M.L. Natural history of inhalation melioidosis in rhesus macaques (Macaca mulatta) and African green monkeys (Chlorocebus aethiops). Infect. Immun. 2012, 80:3332-3340.
27. Rowland C.A., Lertmemongkolchai G., Bancroft A., Haque A., Lever M.S., Griffin K.F., Jackson M.C., Nelson M., O'Garra A., Grencis R., Bancroft G.J., Lukaszewski R.A. Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei. Infect. Immun. 2006, 74:5333-5340.
28. Rowland C.A., Lever M.S., Griffin K.F., Bancroft G.J., Lukaszewski R.A. Protective cellular responses to Burkholderia mallei infection. Microbes Infect. 2010, 12:846-853.
29. Goodyear A., Troyer R., Bielefeldt-Ohmann H., Dow S. MyD88-dependent recruitment of monocytes and dendritic cells required protection from pulmonary Burkholderia mallei infection. Infect. Immun. 2012, 80:110-120.
30. Wiersinga W.J., Wieland C.W., Roelofs J.J., van der Poll T. MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One 2008, 3(10):e3494.