Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Gao, Wei ^a,b   Zhou, Ping ^b   Ma, Xiaocui ^b   Tschudy Seney, Benjamin ^b   Chen, Jiamei ^b,d   Magner, Nataly L ^b   Revzin, Alexander ^c   Nolta, Jan A ^b   Zern, Mark A ^b   Duan, Yuyou ^b  

^a HUNAN UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California Davis   (United States)

^d SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1A; ALCOHOL DEHYDROGENASE 1B; ALCOHOL DEHYDROGENASE 2; ALCOHOL DEHYDROGENASE 4; ASIALOGLYCOPROTEIN RECEPTOR; ASIALOGLYCOPROTEIN RECEPTOR 1; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLIN D1; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE 1A6; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACTIVIN; ACTIVIN A; CCND1 PROTEIN, HUMAN; IMIDE; IWR-1 COMPOUND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NITRILE; QUINOLINE DERIVATIVE; WNT1 PROTEIN; WNT1 PROTEIN, HUMAN;

ALCOHOL METABOLISM; ANIMAL CELL; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; FEEDER CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ACTIVINS; ANIMALS; BETA CATENIN; BUTADIENES; CELL DIFFERENTIATION; CELL LINE; CYCLIN D1; EMBRYONIC STEM CELLS; ETHANOL; FEEDER CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; IMIDES; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUINOLINES; SIGNAL TRANSDUCTION; WNT1 PROTEIN;

EID: 84911879335     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112698     Document Type: Article

References (53)

1. Hoek JB, Pastorino JG. (2002) Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 27(1): 63-8.
2. Adachi Y, Bradford BU, Gao W, Bojes HK, Thurman RG. (1994) Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20(2): 453-60.
3. Crosby HA, Hubscher S, Fabris L, Joplin R, Sell S, et al. (1998) Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. American Journal of Pathology 152(3): 771-779.
4. Tan J, Hytiroglou P, Wieczorek R, Park YN, Thung SN, et al. (2002) Immunohistochemical evidence for hepatic progenitor cells in liver diseases. Liver 22(5): 365-73.
5. Nagy LE. (2004) Molecular aspects of alcohol metabolism: Transcription factors involved in early ethanol-induced injury. Annu Rev Nut 24: 55-78.
6. Neuman MG. (2003) Cytokines - Central Factors in Alcoholic Liver Disease. Alcohol Res. Health 27: 307-316.
7. Tilg H, Diehl AM. (2000) Cytokines in alcoholic and nonalcoholic steatohepatitis. New Eng J Med 343: 1467-1476.
8. Wheeler MD. (2003) Endotoxin and Kupffer Cell Activation in Alcoholic Liver Disease. Alcohol Res Health 27: 300-305.
9. VandeVoort CA, Hill DL, Chaffin CL, Conley AJ. (2011) Ethanol, acetaldehyde and estradiol affect growth and differentiation of rhesus monkey ebryonic stem cells. Alcoholism-Clinical and Experimental Research 35: 1534-1540.
10. Kubota H, Reid LM. (2000) Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen. Proc Natl Acad Sci USA 97: 12132-12137.
11. Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, et al. (2007) Human hepatic stem cells from fetal and postnatal donors. Journal of Experimental Medicine 204(8): 1973-1987.
12. Zhang LL, Theise N, Chua M, Reid LM. (2008) The Stem Cell Niche of Human Livers: Symmetry Between Development and Regeneration. Hepatology 48(5): 1598-1607.
13. Pal R, Mamidi MK, Das AK, Gupta K, Bhonde R. (2012) A Simple and economical route to generate functional hepatocyte-like cells from hESCs and their application in evaluating alcohol induced liver damage. Journal of Cellular Biochemistry 113: 19-30.
14. Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, et al. (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131(7): 1651-1662.
15. D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, et al. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nature Biotech 23(12): 1534-1541.
16. Gouon-Evans V, Boussemart L, Gadue P, Nierhoff D, Koehler CI, et al. (2006) BMP-4 is required for hepatic specification of mouse embryonic stem cellderived definitive endoderm. Nature Biotech 24: 1402-1411.
17. Murry CE, Keller G. (2008) Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 132(4): 661-680.
18. Hay DC, Zhao DB, Fletcher J, Hewitt ZA, McLean D, et al. (2008) Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells 26(4): 894-902.
19. Shirahashi H, Wu J, Yamamoto N, Catana A, Wege H, et al. (2004) Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant 13(3): 197-211.
20. Duan Y, Catana A, Meng Y, He S, Gupta S, et al. (2007) Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo using lentivirus systems. Stem Cells 25: 3058-3068.
21. Duan Y, Ma X, Zou W, Wang C, Bahbahan IS, et al. (2010) Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells. Stem Cells 28(4): 674-686.
22. Li L, Krantz ID, Deng Y, Genin A, Banta AB, et al. (1997) Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet 16: 243-251.
23. Krishan A. (1975) Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 66(1): 188-193.
24. McCoy JP (2002). Flow Cytometry. In: McClatchey KD, editor. Clinical Laboratory Medicine, 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 1403-1425.
25. Deutsch G, Jung J, Zheng M, Lóra J, Zaret SK. (2001) A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128: 871-81.
26. Zaret KS, Grompe M. (2008) Generation and regeneration of cells of the liver and pancreas. Science 322: 1490-1494.
27. Magner NL, Jung Y, Wu J, Nolta JA, Zern MA, et al. (2013) Insulin and igfs enhance hepatocyte differentiation from human embryonic stem cells via the PI3 K/AKT pathway. Stem Cells 31: 2095-103.
28. Lu T, Yang C, Sun H, Lv J, Zhang F, et al. (2014) FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway. Genetics and Molecular Research 13(1): 415-424.
29. Si-Tayeb K, Lemaigre F, Duncan SA. (2010) Organogenesis and development of the liver. Developmental Cell 18: 175-189.
30. Williams JM, Oh SH, Jorgensen M, Steiger N, Darwiche H, et al. (2010) The role of the Wnt family of secreted proteins in rat oval stem cell-based liver regeneration. Am J Pathology 176: 2732-2742.
31. Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, et al. (2012) Macrophage derived Wnt signaling opposes Notch signaling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse. Nat Med 18(4): 572-579.
32. Clevers H, Nusse R. (2012) Wnt/b-catenin signaling and disease. Cell 149: 1192-1205.
33. Ding Q, Xia W, Liu J, Yang J, Lee D, et al. (2005) Erk associates with and primes GSK-3b for its inactivation resulting in upregulation of β-catenin. Molecular Cell 19: 159-170.
34. Yun M, Kim S, Jeon S, Lee J, Choi K. (2004) Both ERK and Wnt/ b-catenin pathways are involved in Wnt3a-induced proliferation. J of Cell Science 118: 313-322.
35. McLin VA, Rankin SA, Zorn MA. (2007) Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 134: 2207-17.
36. Wells JM. (2000) Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 127: 1563-72.
37. Jung J, Zheng M, Goldfarb M, Zaret KS. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284: 1998-2003.
38. Rossi JM, Dunn NR, Hogan BL, Zaret KS. (2001) Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 15: 1998-2009.
39. Shin D, Shin CH, Tucker J, Ober EA, Rentzsch F, et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134: 2041-50.
40. Calmont A, Wandzioch E, Tremblay KD, Minowada G, Kaestner KH, et al. (2006) An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell 11: 339-48.
41. Zaret KS. (2008) Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet 9: 329-40.
42. Lanner F, Rossant J. (2010) The role of FGF/Erk signaling in pluripotent cells. Development 137: 3351-3360.
43. Hanna J, Markoulaki S, Mitalipova M, Cheng AW, Cassady JP, et al. (2009) Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 4: 513-524.
44. Hanna J, Cheng AW, Saha K, Kim J, Lengner CJ, et al. (2010) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 107: 9222-9227.
45. Greber B, Wu G, Bernemann C, Joo JY, Han DW, et al. (2010) Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6: 215-226.
46. Li W, Wei W, Zhu S, Zhu J, Shi Y, et al. (2009) Generation of rat and human induced pluripotent stem cells by combing genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009; 4: 16-19.
47. Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, et al. (2007) FGF stimulation of the Erk1/2 signaling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134: 2895-2902.
48. Peng S, Zhou G, Luk KD, Cheung KM, Li Z, et al. (2009) Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell Physiol Biochem 23: 165-174.
49. Zhang A, Wang Y, Ye Z, Xie H, Zhou L, et al. (2010) Mechanism of TNF-alpha- induced migration and hepatocyte growth factor production in human mesenchymal stem cells. J Cell Biochem 111: 469-475.
50. Li J, Zhao Z, Liu J, Huang N, Long D, et al. (2010) MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta/Smads pathway. Cell Prolif 43: 333-343.
51. Monga SP, Monga HK, Tan X, Mulé K, Pediaditakis P, et al. (2003) Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 124: 202-216.
52. Ober EA, Verkade H, Field HA, Stainier DY. (2006) Mesodermal Wnt2b signaling positively regulates liver specification. Nature 442: 688-91.
53. Goessling W, North TE, Lord AM, Ceol C, Lee S, et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol 320: 161-174.