Selective protein kinase Cθ (PKCθ) inhibitors for the treatment of autoimmune diseases

Biochemical Society Transactions

Volumn 42, Issue 6, 2014, Pages 1524-1528

  Curnock, Adam ^a   Bolton, Clare ^a   Chiu, Peter ^a   Doyle, Elisabeth ^a   Fraysse, Damien ^a   Hesse, Matthias ^a   Jones, Julie ^a   Weber, Peter ^a   Jimenez, Juan Miguel ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Autoimmunity; Colitis; Experimental autoimmune encephalomyelitis (EAE); Memory T cell; Protein kinase C (PKC ); T cell

Indexed keywords

PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; ISOENZYME; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

ARTICLE; AUTOIMMUNE DISEASE; CROSS REACTION; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY DISEASE; LIPOPHILICITY; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; NONHUMAN; PROCESS OPTIMIZATION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; MOUSE;

ANIMALS; AUTOIMMUNE DISEASES; HUMANS; ISOENZYMES; MICE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS;

EID: 84911867456     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140167     Document Type: Article

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