The relation between hypointense core, microvascular obstruction and intramyocardial haemorrhage in acute reperfused myocardial infarction assessed by cardiac magnetic resonance imaging

European Radiology

Volumn 24, Issue 12, 2014, Pages 3277-3288

  Kandler, Diana ^a   Lücke, Christian ^a   Grothoff, Matthias ^a   Andres, Claudia ^a   Lehmkuhl, Lukas ^a   Nitzsche, Stefan ^a   Riese, Franziska ^a   Mende, Meinhard ^a   de Waha, Suzanne ^a   Desch, Steffen ^a   Lurz, Philipp ^a   Eitel, Ingo ^a   Gutberlet, Matthias ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Acute myocardial infarction; Cardiac magnetic resonance imaging; Haemorrhage; Hypointense core; Microvascular obstruction

Indexed keywords

GADOLINIUM PENTETATE;

ADULT; AGED; ANGIOPLASTY; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BLOOD VESSEL OCCLUSION; CARDIOVASCULAR MAGNETIC RESONANCE; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE INJURY; HEART VENTRICLE FUNCTION; HUMAN; HYPOINTENSE CORE; INTRAMYOCARDIAL HAEMORRHAGE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SCANNER; RADIOLOGICAL PARAMETERS; REPERFUSION INJURY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; CORONARY ARTERY BLOOD FLOW; ELECTROCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE REPERFUSION; HEART VENTRICLE; HEMORRHAGE; MIDDLE AGED; MYOCARDIAL INFARCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RETROSPECTIVE STUDY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CORONARY CIRCULATION; ELECTROCARDIOGRAPHY; FEMALE; HEART VENTRICLES; HEMORRHAGE; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; MYOCARDIUM; RETROSPECTIVE STUDIES; VENTRICULAR FUNCTION, LEFT;

EID: 84911811943     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-014-3318-3     Document Type: Article

References (49)

1. Jaffe R, Charron T, Puley G, Dick A, Strauss BH (2008) Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention. Circulation 117:3152–3156
2. Higginson LA, White F, Heggtveit HA, Sanders TM, Bloor CM, Covell JW (1982) Determinants of myocardial hemorrhage after coronary reperfusion in the anesthetized dog. Circulation 65:62–69
3. Beek AM, Nijveldt R, van Rossum AC (2010) Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention. Int J Cardiovasc Imaging 26:49–55
4. Bekkers SC, Yazdani SK, Virmani R, Waltenberger J (2010) Microvascular obstruction: underlying pathophysiology and clinical diagnosis. J Am Coll Cardiol 55:1649–1660
5. Eitel I, Kubusch K, Strohm O, Desch S, Mikami Y, de Waha S, Gutberlet M, Schuler G, Friedrich MG, Thiele H (2011) Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation-myocardial infarction. Circ Cardiovasc Imaging 4:354–362
6. Fishbein MC, Y-Rit J, Lando U, Kanmatsuse K, Mercier JC, Ganz W (1980) The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion. Circulation 62:1274–1279
7. Ochiai K, Shimada T, Murakami Y, Ishibashi Y, Sano K, Kitamura J, Inoue S, Murakami R, Kawamitsu H, Sugimura K (1999) Hemorrhagic myocardial infarction after coronary reperfusion detected in vivo by magnetic resonance imaging in humans: prevalence and clinical implications. J Cardiovasc Mag Reson 1:247–256
8. Basso C, Corbetti F, Silva C, Abudureheman A, Lacognata C, Cacciavillani L, Tarantini G, Marra MP, Ramondo A, Thiene G, Iliceto S (2007) Morphologic validation of reperfused hemorrhagic myocardial infarction by cardiovascular magnetic resonance. Am J Cardiol 100:1322–1327
9. Van den Bos EJ, Baks T, Moelker AD, Kerver W, van Geuns RJ, van der Giessen WJ, Duncker DJ, Wielopolski PA (2006) Magnetic resonance imaging of haemorrhage within reperfused myocardial infarcts: possible interference with iron oxide-labelled cell tracking? Eur Heart J 27:1620–1626
10. Ghugre NR, Ramanan V, Pop M, Yang Y, Barry J, Qiang B, Connelly KA, Dick AJ, Wright GA (2011) Quantitative tracking of edema, hemorrhage, and microvascular obstruction in subacute myocardial infarction in a porcine model by MRI. Magn Reson Med 66:1129–1141
11. *-weighted CMR. JACC Cardiovasc Imaging 4:1274–1283
12. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121–1135
13. Dirksen MT, Laarman GJ, Simoons ML, Duncker DJ (2007) Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc Res 74:343–355
14. Asanuma T, Tanabe K, Ochiai K, Yoshitomi H, Nakamura K, Murakami Y, Sano K, Shimada T, Murakami R, Morioka S, Beppu S (1997) Relationship between progressive microvascular damage and intramyocardial hemorrhage in patients with reperfused anterior myocardial infarction: myocardial contrast echocardiographic study. Circulation 96:448–453
15. Ganame J, Messalli G, Dymarkowski S, Rademakers FE, Desmet W, Van de Werf F, Bogaert J (2009) Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur Heart J 30:1440–9
16. * mapping and effect on measuring the area at risk. Radiology 250:916–922
17. Bradley WG Jr (1993) MR appearance of hemorrhage in the brain. Radiology 189:15–26
18. Parizel PM, Makkat S, Van Miert E, Van Goethem JW, van den Hauwe L, De Schepper AM (2001) Intracranial hemorrhage: principles of CT and MRI interpretation. Eur Radiol 11:1770–1783
19. Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R (2008) The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol 51:1581–1587
20. O´Regan DP, Ahmed R, Neuwirth C, Tan Y, Durighel G, Hajnal JV, Nadra I, Corbett SJ, Cook SA (2009) Cardiac MRI of myocardial salvage at the peri-infarct border zones after primary coronary intervention. Am J Physiol Heart Circ Physiol 297:H340–346
21. Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, Thiele H (2010) Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol 55:2470–2479
22. Cannan C, Eitel I, Hare J, Kumar A, Friedrich M (2010) Hemorrhage in the myocardium following infarction. JACC Cardiovasc Imaging 3:665–668
23. Thiele H, Wöhrle J, Neuhaus P, Brosteanu O, Sick P, Prondzinsky R, Birkemeyer R, Wiemer M, Kerber S, Schuehlen H, Kleinertz K, Axthelm C, Zimmermann R, Rittger H, Braun-Dullaeus RC, Lauer B, Burckhardt W, Ferrari M, Bergmann MW, Hambrecht R, Schuler G, Abciximab Intracoronary versus intravenously Drug Application in ST-Elevation Myocardial Infarction (AIDA STEMI) Investigators (2010) Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention: design and rationale of the Abciximab Intracoronary versus intravenously Drug Application in ST-Elevation Myocardial Infarction (AIDA STEMI) trial. Am Heart J 159:547–554
24. Thiele H, Wöhrle J, Hambrecht R, Rittger H, Birkemeyer R, Lauer B, Neuhaus P, Brosteanu O, Sick P, Wiemer M, Kerber S, Kleinertz K, Eitel I, Desch S, Schuler G (2012) Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial. Lancet 379:923–931
25. Eitel I, Wöhrle J, Suenkel H, Meissner J, Kerber S, Lauer B, Pauschinger M, Birkemeyer R, Axthelm C, Zimmermann R, Neuhaus P, Brosteanu O, de Waha S, Desch S, Gutberlet M, Schuler G, Thiele H (2013) Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: cardiac magnetic resonance substudy of the AIDA STEMI trial. J Am Coll Cardiol 61:1447–1454
26. Chesebro JH, Knatterud G, Roberts R, Borer J, Cohen LS, Dalen J, Dodge HT, Francis CK, Hillis D, Ludbrook P (1987) Thrombolysis in myocardial infarction (TIMI) trial, phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation 76:142–154
27. Grothoff M, Elpert C, Hoffmann J, Zachrau J, Lehmkuhl L, de Waha S, Desch S, Eitel I, Mende M, Thiele H, Gutberlet M (2012) Right ventricular injury in ST-elevation myocardial infarction: risk stratification by visualization of wall motion, edema, and delayed-enhancement cardiac magnetic resonance. Circ Cardiovasc Imaging 5:60–68
28. Gutberlet M, Abdul-Khaliq H, Grothoff M, Schröter J, Schmitt B, Röttgen R, Lange P, Vogel M, Felix R (2003) Evaluation of left ventricular volumes in patients with congenital heart disease and abnormal left ventricular geometry. Comparison of MRI and transthoracic 3-dimensional echocardiography. RöFo 175:942–951
29. Shapiro EP, Rogers WJ, Beyar R, Soulen RL, Zerhouni EA, Lima JA, Weiss JL (1989) Determination of left ventricular mass by magnetic resonance imaging in hearts deformed by acute infarction. Circulation 79:706–711
30. Lotan CS, Bouchard A, Cranney GB, Bishop SP, Pohost GM (1992) Assessment of postreperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T. Circulation 86:1018–1025
31. Lotan CS, Miller SK, Cranney GB, Pohost GM, Elgavish GA (1992) The effect of postinfarction intramyocardial hemorrhage on transverse relaxation time. Magn Reson Med 23:346–355
32. * mapping at multiple time intervals post ST-segment elevation myocardial infarction. Circ Cardiovasc Imaging 5:566–572
33. Kali A, Kumar A, Cokic I, Tang RL, Tsaftaris SA, Friedrich MG, Dharmakumar R (2013) Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition: a cardiovascular magnetic resonance study with ex vivo validation. Circ Cardiovasc Imaging 6:218–228
34. Kali A, Tang RL, Kumar A, Min JK, Dharmakumar R (2013) Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging: T2 versus T2. Radiology 269:387–395
35. Jackowski C, Christe A, Sonnenschein M, Aghayev E, Thali MJ (2006) Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization. Eur Heart J 27:2459–2467
36. O'Regan DP, Ariff B, Neuwirth C, Tan Y, Durighel G, Cook SA (2010) Assessment of severe reperfusion injury with T2* cardiac MRI in patients with acute myocardial infarction. Heart 96:1885–1891
37. Gutberlet M, Fröhlich M, Mehl S, Amthauer H, Hausmann H, Meyer R, Siniawski H, Ruf J, Plotkin M, Denecke T, Schnackenburg B, Hetzer R, Felix R (2005) Myocardial viability assessment in patients with highly impaired left ventricular function: comparison of delayed enhancement, dobutamine stress MRI, end-diastolic wall thickness, and TI201-SPECT with functional recovery after revascularization. Eur Radiol 15:872–880
38. Husser O, Monmeneu JV, Sanchis J, Nunez J, Lopez-Lereu MP, Bonanad C, Chaustre F, Gomez C, Bosch MJ, Hinarejos R, Chorro FJ, Riegger GA, Llacer A, Bodi V (2012) Cardiovascular magnetic resonance-derived intramyocardial hemorrhage after STEMI: Influence on long-term prognosis, adverse left ventricular remodeling and relationship with microvascular obstruction. Int J Cardiol. doi:10.1016/j.ijcard.2012.05.055
39. Ahmed N, Carrick D, Layland J, Oldroyd KG, Berry C (2012) The role of cardiac magnetic resonance imaging (MRI) in acute myocardial infarction (AMI). Heart Lung Circ 22:243–255
40. Pedersen SF, Thrysøe SA, Robich MP, Paaske WP, Ringgaard S, Bøtker HE, Hansen ES, Kim WY (2012) Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction. J Cardiovasc Magn Reson 14:59–67
41. Bekkers SC, Smulders MW, Passos VL, Leiner T, Waltenberger J, Gorgels AP, Schalla S (2010) Clinical implications of microvascular obstruction and intramyocardial haemorrhage in acute myocardial infarction using cardiovascular magnetic resonance imaging. Eur Radiol 20:2572–2578
42. Wiesmann M, Mayer TE, Yousry I, Hamann GF, Bruckmann H (2001) Detection of hyperacute parenchymal hemorrhage of the brain using echo-planar T2*-weighted and diffusion-weighted MRI. Eur Radiol 11:849–853
43. Linfante I, Llinas RH, Caplan LR, Warach S (1999) MRI features of intracerebral hemorrhage within 2 hours from symptom onset. Stroke 30:2263–2267
44. Robbers LF, Eerenberg ES, Teunissen PF, Jansen MF, Hollander MR, Horrevoets AJ, Knaapen P, Nijveldt R, Heymans MW, Levi MM, van Rossum AC, Niessen HW, Marcu CB, Beek AM, van Royen N (2013) Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage. Eur Heart J 34:2346–2353
45. Amabile N, Jacquier A, Shuhab A, Gaudart J, Bartoli JM, Paganelli F, Moulin G (2012) Incidence, predictors, and prognostic value of intramyocardial hemorrhage lesions in ST elevation myocardial infarction. Catheter Cardiovasc Interv 79:1101–1108
46. Chen ZM, Pan HC, Chen YP et al (2005) Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366:1622–1632
47. Antman EM, Hand M, Armstrong PW et al (2008) 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 51:210–247
48. Anzalone N, Scotti R, Riva R (2004) Neuroradiologic differential diagnosis of cerebral intraparenchymal hemorrhage. Neurol Sci. doi:10.1007/s10072-004-0205-8
49. Wu KC (2012) CMR of microvascular obstruction and hemorrhage in myocardial infarction. J Cardiovasc Magn Reson 14:68