Activated protein C (APC) can increase bone anabolism via a protease-activated receptor (PAR)1/2 dependent mechanism

Journal of Orthopaedic Research

Volumn 32, Issue 12, 2014, Pages 1549-1556

  Shen, Kaitlin ^a   Murphy, Ciara M ^b,c   Chan, Ben ^a   Kolind, Mille ^b   Cheng, Tegan L ^b,c   Mikulec, Kathy ^b   Peacock, Lauren ^b   Xue, Meilang ^a   Park, Sang Youel ^d   Little, David G ^b,c   Jackson, Chris J ^a   Schindeler, Aaron ^b,c  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^c University of Sydney   (Australia)

^d Chonbuk National University   (South Korea)

Author keywords

Activated protein C; APC; Bone anabolism; PAR1 2; RhBMP 2 induced bone

Indexed keywords

ACTIVATED PROTEIN C; BLOCKING ANTIBODY; BONE MORPHOGENETIC PROTEIN 2; ENDOTHELIAL PROTEIN C RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; BMP2 PROTEIN, HUMAN; PROTEIN C;

ANGIOGENESIS; ARTICLE; BONE CELL; BONE MASS; BONE METABOLISM; BONE REMODELING; BONE TURNOVER; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; TISSUE SECTION; VASCULARIZATION; ANIMAL; BONE; BONE DEVELOPMENT; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; METABOLISM; MOUSE; OSTEOLYSIS; PHYSIOLOGY; PREVENTION AND CONTROL;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; BONE RESORPTION; CELLS, CULTURED; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOGENESIS; PROTEIN C; RECEPTOR, PAR-1; RECEPTOR, PAR-2;

EID: 84911806423     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22726     Document Type: Article

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