Leucocyte telomere length and risk of type 2 diabetes mellitus: New prospective cohort study and literature-based meta-analysis

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Willeit, Peter ^a,b   Raschenberger, Julia ^a   Heydon, Emma E ^b   Tsimikas, Sotirios ^c   Haun, Margot ^a   Mayr, Agnes ^d   Weger, Siegfried ^d   Witztum, Joseph L ^c   Butterworth, Adam S ^b   Willeit, Johann ^a   Kronenberg, Florian ^a   Kiechl, Stefan ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d BRUNECK HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD SAMPLING; BODY MASS; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FOLLOW UP; HAZARD RATIO; HUMAN; HUMAN CELL; INCIDENCE; LEUCOCYTE RELATIVE TELOMERE LENGTH; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL COMPUTING; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPIC VARIATION; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; PROPORTIONAL HAZARDS MODEL; QUANTITATIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SMOKING; SOCIAL STATUS; TELOMERE HOMEOSTASIS; WAIST HIP RATIO; AGE; BLOOD; CHEMISTRY; DRINKING BEHAVIOR; GENETICS; META ANALYSIS; METABOLISM; MIDDLE AGED; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; SEX DIFFERENCE; SOCIAL CLASS; TELOMERE; TELOMERE SHORTENING;

ADULT; AGE FACTORS; AGED; ALCOHOL DRINKING; BODY MASS INDEX; C-REACTIVE PROTEIN; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MOTOR ACTIVITY; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; SOCIAL CLASS; TELOMERE; TELOMERE SHORTENING; WAIST-HIP RATIO;

EID: 84911489352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112483     Document Type: Article

References (50)

1. Blackburn EH (1991) Structure and function of telomeres. Nature 350: 569-573.
2. Calado RT, Young NS (2009) Telomere diseases. N Engl J Med 361: 2353-2365.
3. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636.
4. Weischer M, Bojesen SE, Cawthon RM, Freiberg JJ, Tybjærg-Hansen A, et al. (2012) Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol 32: 822-829.
5. Willeit P, Willeit J, Brandstä tter A, Ehrlenbach S, Mayr A, et al. (2010) Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk. Arterioscler Thromb Vasc Biol 30: 1649-1656.
6. Zee RY, Michaud SE, Germer S, Ridker PM (2009) Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. Clin Chim Acta 403: 139-141.
7. Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, et al. (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 369: 107-114.
8. Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, et al. (2014) Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 349: g4227.
9. Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA (2011) The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 20: 1238-1250.
10. Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, et al. (2010) Telomere length and risk of incident cancer and cancer mortality. JAMA 304: 69-75.
11. Ma H, Zhou Z, Wei S, Liu Z, Pooley KA, et al. (2011) Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 6: e20466.
12. Zhao J, Miao K, Wang H, Ding H, Wang DW (2013) Association between telomere length and type 2 diabetes mellitus: a meta-analysis. PLoS One 8: e79993.
13. Kuhlow D, Florian S, von Figura G, Weimer S, Schulz N, et al. (2010) Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) 2: 650-658.
14. Guo N, Parry EM, Li LS, Kembou F, Lauder N, et al. (2011) Short telomeres compromise b-cell signaling and survival. PLoS One 6: e17858.
15. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, et al. (2009) A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15: 1082-1087.
16. Roberts CK, Sindhu KK (2009) Oxidative stress and metabolic syndrome. Life Sci 84: 705-712.
17. Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ (2008) Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 44: 235-246.
18. Weischer M, Bojesen SE, Nordestgaard BG (2014) Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart. PLoS Genet 10: e1004191.
19. Willeit P, Willeit J, Kloss-Brandstä tter A, Kronenberg F, Kiechl S (2011) Fifteenyear follow-up of association between telomere length and incident cancer and cancer mortality. JAMA 306: 42-44.
20. Svenson U, Nordfjä ll K, Baird D, Roger L, Osterman P, et al. (2011) Blood cell telomere length is a dynamic feature. PLoS One 6: e21485.
21. Huzen J, Wong LS, van Veldhuisen DJ, Samani NJ, Zwinderman AH, et al. (2014) Telomere length loss due to smoking and metabolic traits. J Intern Med 275: 155-163.
22. Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, et al. (2014) Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study. Am J Hum Biol 26: 367-375.
23. Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, et al. (2009) The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) 1: 81-88.
24. Nordfjä ll K, Svenson U, Norrback KF, Adolfsson R, Lenner P, et al. (2009) The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet 5: e1000375.
25. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M, et al. (2009) Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 169: 323-329.
26. Chen W, Kimura M, Kim S, Cao X, Srinivasan SR, et al. (2011) Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: agedependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci 66: 312-319.
27. Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, et al. (2010) Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One 5: e8612.
28. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, et al. (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347: 185-192.
29. Kloss-Brandstä tter A, Willeit P, Lamina C, Kiechl S, Kronenberg F (2010) Correlation between baseline telomere length and shortening over time-spurious or true? Int J Epidemiol 40: 840-841.
30. Baecke JA, Burema J, Frijters JE (1982) A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 36: 936-942.
31. Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, et al. (2012) Oxidationspecific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol 60: 2218-2229.
32. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, et al. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23: 57-63.
33. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
34. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30: e47.
35. Raschenberger J, Kollerits B, Hammerer-Lercher A, Rantner B, Stadler M, et al. (2013) The association of relative telomere length with symptomatic peripheral arterial disease: results from the CAVASIC study. Atherosclerosis 229: 469-474.
36. Pfaffl MW (2001) A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 29: e45.
37. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26: 3160-3167.
38. Wells G, Shea B, Peterson J, Welch V, Losos M, et al. (2000) The Newcastle- Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. Available: http://www.ohri.ca/programs/clinical-epidemiology/ oxford.htm. Accessed 12 May 2014.
39. Wood AM, White I, Thompson SG, Lewington S, Danesh J (2006) Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies. Int J Epidemiol 35: 1570-1578.
40. Fibrinogen Studies Collaboration (2009) Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. Stat Med 28: 1067-1092.
41. Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, et al. (2014) Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study. Diabetes 63: 354-362.
42. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560.
43. Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
44. Hovatta I, de Mello VD, Kananen L, Lindström J, Eriksson JG, et al. (2012) Leukocyte telomere length in the Finnish Diabetes Prevention Study. PLoS One 7: e34948.
45. You NC, Chen BH, Song Y, Lu X, Chen Y, et al. (2012) A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women. Diabetes 61: 2998-3004.
46. Cohen S, Janicki-Deverts D, Turner RB, Casselbrant ML, Li-Korotky HS, et al. (2013) Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA 309: 699-705.
47. Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, et al. (2010) Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods 352: 71-80.
48. Zee RY, Ridker PM, Chasman DI (2011) Genetic variants of 11 telomerepathway gene loci and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. Atherosclerosis 218: 144-146.
49. Xu J, Ye J, Wu Y, Zhang H, Luo Q, et al. (2014) Reduced fetal telomere length in gestational diabetes. PLoS One 9: e86161.
50. Du M, Prescott J, Cornelis MC, Hankinson SE, Giovannucci E, et al. (2013) Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study. PLoS One 8: e52240.