A substrate pharmacophore for the human sodium taurocholate co-transporting polypeptide

International Journal of Pharmaceutics

Volumn 478, Issue 1, 2015, Pages 88-95

  Dong, Zhongqi ^a   Ekins, Sean ^b   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Collaborations in Chemistry ^*  (United States)

Author keywords

Bile acids; Irbesartan; Losartan; Pharmacophore; Sodium taurocholate co transporting polypeptide (NTCP); Transporters

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEHYDROCHOLIC ACID; DEOXYCHOLIC ACID; GLYCOCHENODEOXYCHOLIC ACID; GLYCOCHOLIC ACID; GLYCODEOXYCHOLIC ACID; GLYCOLITHOCHOLIC ACID; GLYCOURSODEOXYCHOLATE; HYDROXYL GROUP; HYODEOXYCHOLIC ACID; IRBESARTAN; LITHOCHOLIC ACID; LOSARTAN; ROSUVASTATIN; SODIUM BILE ACID COTRANSPORTER; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROHYODEOXYCHOLATE; TAUROLITHOCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BIPHENYL DERIVATIVE; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TETRAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; INHIBITION KINETICS; PHARMACOPHORE; PROTEIN BINDING; PROTEIN TRANSPORT; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HEK293 CELL LINE; METABOLISM;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BILE ACIDS AND SALTS; BIPHENYL COMPOUNDS; HEK293 CELLS; HUMANS; LOSARTAN; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SYMPORTERS; TETRAZOLES;

EID: 84911487145     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.022     Document Type: Article

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