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Volumn 9, Issue 12, 2014, Pages 2740-2754

Production and analysis of immunomodulatory excretory-secretory products from the mouse gastrointestinal nematode Heligmosomoides polygyrus bakeri

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EXCRETORY SECRETORY PRODUCT; SECRETORY PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; GLYCOPROTEIN P 15095; IMMUNOLOGIC FACTOR;

EID: 84911477907     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2014.184     Document Type: Article
Times cited : (23)

References (61)
  • 1
    • 33845695229 scopus 로고    scopus 로고
    • Multiple sclerosis and the hygiene hypothesis
    • Fleming, J.O. & Cook, T.D. Multiple sclerosis and the hygiene hypothesis. Neurology 67, 2085-2086 (2006).
    • (2006) Neurology , vol.67 , pp. 2085-2086
    • Fleming, J.O.1    Cook, T.D.2
  • 2
    • 18844374468 scopus 로고    scopus 로고
    • A worm's eye view of the immune system: Consequences for evolution of human autoimmune disease
    • Dunne, D.W. & Cooke, A. A worm's eye view of the immune system: consequences for evolution of human autoimmune disease. Nat. Rev. Immunol. 5, 420-426 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 420-426
    • Dunne, D.W.1    Cooke, A.2
  • 3
    • 83755219473 scopus 로고    scopus 로고
    • Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    • Molodecky N.A.,et al Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review Gastroenterology 142, 46-54, 2012).
    • (2012) Gastroenterology , vol.142 , pp. 46-54
    • Molodecky, N.A.1
  • 4
    • 0037134046 scopus 로고    scopus 로고
    • Allergy parasites, and the hygiene hypothesis
    • Yazdanbakhsh, M., Kremsner, P.G. & van Ree, R. Allergy, parasites, and the hygiene hypothesis. Science 296, 490-494 (2002).
    • (2002) Science , vol.296 , pp. 490-494
    • Yazdanbakhsh, M.1    Kremsner, P.G.2    Van Ree, R.3
  • 5
    • 84890427809 scopus 로고    scopus 로고
    • Global progress towards eliminating gastrointestinal helminth infections
    • McCarty, T.R., Turkeltaub, J.A. & Hotez, P.J. Global progress towards eliminating gastrointestinal helminth infections. Curr. Opin. Gastroenterol. 30, 18-24 (2014).
    • (2014) Curr. Opin. Gastroenterol , vol.30 , pp. 18-24
    • McCarty, T.R.1    Turkeltaub, J.A.2    Hotez, P.J.3
  • 6
    • 84873582493 scopus 로고    scopus 로고
    • Translatability of helminth therapy
    • Artis, D. Translatability of helminth therapy. Int. J. Parasitol. 43, 189 (2013).
    • (2013) Int. J. Parasitol , vol.43 , pp. 189
    • Artis, D.1
  • 7
    • 84873733555 scopus 로고    scopus 로고
    • Translatability of helminth therapy in inflammatory bowel diseases
    • Weinstock, J.V. & Elliott, D.E. Translatability of helminth therapy in inflammatory bowel diseases. Int. J. Parasitol. 43, 245-251 (2013).
    • (2013) Int. J. Parasitol , vol.43 , pp. 245-251
    • Weinstock, J.V.1    Elliott, D.E.2
  • 8
    • 4844229387 scopus 로고    scopus 로고
    • Helminth parasites-masters of regulation
    • Maizels, R.M. et al. Helminth parasites-masters of regulation. Immunol. Rev. 201, 89-116 (2004).
    • (2004) Immunol. Rev , vol.201 , pp. 89-116
    • Maizels, R.M.1
  • 9
    • 59449106343 scopus 로고    scopus 로고
    • Parasitic helminths: A pharmacopoeia of anti-inflammatory molecules
    • Johnson, M.J.G., MacDonald, J.A. & McKay, D.M. Parasitic helminths: a pharmacopoeia of anti-inflammatory molecules. Parasitology 136, 125-147 (2008).
    • (2008) Parasitology , vol.136 , pp. 125-147
    • Johnson, M.J.G.1    Macdonald, J.A.2    McKay, D.M.3
  • 10
    • 67650355471 scopus 로고    scopus 로고
    • Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity
    • Hewitson, J.P., Grainger, J.R. & Maizels, R.M. Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity. Mol. Biochem. Parasitol. 167, 1-11 (2009).
    • (2009) Mol. Biochem. Parasitol , vol.167 , pp. 1-11
    • Hewitson, J.P.1    Grainger, J.R.2    Maizels, R.M.3
  • 11
    • 34447547494 scopus 로고    scopus 로고
    • Impairment of dendritic cell function by excretory-secretory products: A potential me chanism for nematode-induced immunosuppression
    • Segura, M., Su, Z., Piccirillo, C. & Stevenson, M.M. Impairment of dendritic cell function by excretory-secretory products: a potential me chanism for nematode-induced immunosuppression. Eur. J. Immunol. 37, 1887-1904 (2007).
    • (2007) Eur. J. Immunol , vol.37 , pp. 1887-1904
    • Segura, M.1    Su, Z.2    Piccirillo, C.3    Stevenson, M.M.4
  • 12
    • 80055099099 scopus 로고    scopus 로고
    • Proteomic analysis of excretory-secretory products of heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information
    • Moreno, Y. et al. Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information. PLoS Negl. Trop. Dis. 5, e1370 (2011).
    • (2011) PLoS Negl. Trop. Dis , vol.5 , pp. e1370
    • Moreno, Y.1
  • 13
    • 44649133452 scopus 로고    scopus 로고
    • Animal models of nippostrongylus brasiliensis and heligmosomoides polygyrus
    • Camberis, M., Le Gros, G. & Urban, J. Jr. Animal models of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr. Protoc. Immunol. S55, 19.12.1-19.12.27 (2003).
    • (2003) Curr. Protoc. Immunol , vol.S55 , pp. 19121-191227
    • Camberis, M.1    Le Gros, G.2    Urban, J.3
  • 14
    • 80051671154 scopus 로고    scopus 로고
    • Proteomic analysis of secretory products from the model gastrointestinal nematode heligmosomoides polygyrus reveals dominance of venom allergen-like (val) proteins
    • Hewitson, J.P. et al. Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. J. Proteomics 74, 1573-1594 (2011).
    • (2011) J. Proteomics , vol.74 , pp. 1573-1594
    • Hewitson, J.P.1
  • 15
    • 0030935344 scopus 로고    scopus 로고
    • Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models
    • Finkelman, F.D. et al. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15, 505-533 (1997).
    • (1997) Annu. Rev. Immunol , vol.15 , pp. 505-533
    • Finkelman, F.D.1
  • 16
    • 0038739290 scopus 로고    scopus 로고
    • The immune response to parasitic helminths: Insights from murine models
    • Gause, W.C., Urban, J.F. & Stadecker, M.J. The immune response to parasitic helminths: insights from murine models. Trends Immunol. 24, 269-277 (2003).
    • (2003) Trends Immunol , vol.24 , pp. 269-277
    • Gause, W.C.1    Urban, J.F.2    Stadecker, M.J.3
  • 17
    • 84876050140 scopus 로고    scopus 로고
    • Immunity to the model intestinal helminth parasite heligmosomoides polygyrus
    • Reynolds, L.A., Filbey, K.J. & Maizels, R.M. Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus. Semin. Immunopathol. 34, 829-846 (2012).
    • (2012) Semin. Immunopathol , vol.34 , pp. 829-846
    • Reynolds, L.A.1    Filbey, K.J.2    Maizels, R.M.3
  • 18
    • 0032875076 scopus 로고    scopus 로고
    • The relationship between circulating and intestinal heligmosomoides polygyrus-specific igg1 and iga and resistance to primary i nfection
    • Ben-Smith, A., Wahid, F.N., Lammas, D.A. & Behnke, J.M. The relationship between circulating and intestinal Heligmosomoides polygyrus-specific IgG1 and IgA and resistance to primary i nfection. Parasite Immunol. 21, 383-395 (1999).
    • (1999) Parasite Immunol , vol.21 , pp. 383-395
    • Ben-Smith, A.1    Wahid, F.N.2    Lammas, D.A.3    Behnke, J.M.4
  • 19
    • 84971149822 scopus 로고
    • Immunological relationships during primary infection with heligmosomoides polygyrus ( nematospiroides dubius): Dose-dependent expulsion of adult worms
    • Robinson, M., Wahid, F., Behnke, J.M. & Gilbert, F.S. Immunological relationships during primary infection with Heligmosomoides polygyrus ( Nematospiroides dubius): dose-dependent expulsion of adult worms. Parasitology 98, 115-124 (1989).
    • (1989) Parasitology , vol.98 , pp. 115-124
    • Robinson, M.1    Wahid, F.2    Behnke, J.M.3    Gilbert, F.S.4
  • 20
    • 0348140958 scopus 로고    scopus 로고
    • Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
    • Menge, D.M. et al. Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice. Parasite Immunol. 25, 341-349 (2003).
    • (2003) Parasite Immunol , vol.25 , pp. 341-349
    • Menge, D.M.1
  • 21
    • 0021869068 scopus 로고
    • Genetic control of immunity to nematospiroides dubius: A 9-day anthelmintic abbreviated immuni zing regime which separates weak and strong responder stains of mice
    • Behnke, J.M. & Robinson, M. Genetic control of immunity to Nematospiroides dubius: a 9-day anthelmintic abbreviated immuni zing regime which separates weak and strong responder stains of mice. Parasite Immunol. 7, 235-253 (1985).
    • (1985) Parasite Immunol , vol.7 , pp. 235-253
    • Behnke, J.M.1    Robinson, M.2
  • 22
    • 0021400365 scopus 로고
    • The site selected by the larvae of heligmosomoides polygyrus
    • Sukhdeo, M.V., O'Grady, R.T. & Hsu, S.C. The site selected by the larvae of Heligmosomoides polygyrus. J. Helminthol. 58, 19-23 (1984).
    • (1984) J. Helminthol , vol.58 , pp. 19-23
    • Sukhdeo, M.V.1    O'Grady, R.T.2    Hsu, S.C.3
  • 23
    • 0027179991 scopus 로고
    • Immunological relationships during primary infection with heligmosomoides polygyrus (nematospiroides dubius): Downregulation of specific cytokine secretion (il-9 and il-10) correlates with poor mastocytosis and chronic survival of adult worms
    • Behnke, J.M. et al. Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms. Parasite Immunol. 15, 415-421 (1993).
    • (1993) Parasite Immunol , vol.15 , pp. 415-421
    • Behnke, J.M.1
  • 24
    • 0028286334 scopus 로고
    • Immunological relations during primary infection with heligmosomoides polygyrus: Th2 cytokines and primary response phenotype
    • Wahid F.N.,et al Immunological relations during primary infection with Heligmosomoides polygyrus: TH2 cytokines and primary response phenotype Parasitology 108, 461-471, 1994).
    • (1994) Parasitology , vol.108 , pp. 461-471
    • Wahid, F.N.1
  • 25
    • 53649101025 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of enteric hel igmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model
    • Sutton, T.L. et al. Anti-inflammatory mechanisms of enteric Hel igmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model. Infect. Immun. 76, 4772-4782 (2008).
    • (2008) Infect. Immun , vol.76 , pp. 4772-4782
    • Sutton, T.L.1
  • 26
    • 19744364625 scopus 로고    scopus 로고
    • Impairment of protective immunity to blood-stage malaria by concurrent nematode infection
    • Su, Z. et al. Impairment of protective immunity to blood-stage malaria by concurrent nematode infection. Infect. Immun. 73, 3531-3539 (2005).
    • (2005) Infect. Immun , vol.73 , pp. 3531-3539
    • Su, Z.1
  • 27
    • 55849125576 scopus 로고    scopus 로고
    • Alternatively activated macrophages in intestinal helminth infection: Effects on concurrent bacterial colitis
    • Weng, M. et al. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J. Immunol. 179, 4721-4731 (2007).
    • (2007) J. Immunol , vol.179 , pp. 4721-4731
    • Weng, M.1
  • 28
    • 84865425687 scopus 로고    scopus 로고
    • Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut t cell responses
    • Blum, A.M. et al. Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses. J. Immunol. 189, 2512-2520 (2012).
    • (2012) J. Immunol , vol.189 , pp. 2512-2520
    • Blum, A.M.1
  • 29
    • 33746806604 scopus 로고    scopus 로고
    • Memory th2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
    • Anthony, R.M. et al. Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat. Med. 12, 955-960 (2006).
    • (2006) Nat. Med , vol.12 , pp. 955-960
    • Anthony, R.M.1
  • 30
    • 84888257272 scopus 로고    scopus 로고
    • Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving il-4r?-independent alternative differentiation of macrophages
    • Esser-von Bieren, J. et al. Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4R?-independent alternative differentiation of macrophages. PLoS Pathog. 9, e1003771 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. e1003771
    • Esser-Von Bieren, J.1
  • 31
    • 84886696489 scopus 로고    scopus 로고
    • Effect of helminth-induced immunity on infections with microbial pathogens
    • Salgame, P., Yap, G.S. & Gause, W.C. Effect of helminth-induced immunity on infections with microbial pathogens. Nat. Immunol. 14, 1118-1126 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 1118-1126
    • Salgame, P.1    Yap, G.S.2    Gause, W.C.3
  • 32
    • 84873701916 scopus 로고    scopus 로고
    • Immunomodulation by helminth parasites: Defining mechanisms and mediators
    • McSorley, H.J., Hewitson, J.P. & Maizels, R.M. Immunomodulation by helminth parasites: defining mechanisms and mediators. Int. J. Parasitol. 43, 301 (2013).
    • (2013) Int. J. Parasitol , vol.43 , pp. 301
    • McSorley, H.J.1    Hewitson, J.P.2    Maizels, R.M.3
  • 33
    • 78149261083 scopus 로고    scopus 로고
    • Helminth secretions induce de novo t cell foxp3 expression and regulatory function through the tgf-? Pathway
    • Grainger, J.R. et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-? pathway. J. Exp. Med. 207, 2331-2341 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 2331-2341
    • Grainger, J.R.1
  • 34
    • 27144486144 scopus 로고    scopus 로고
    • Suppression of allergic airway inflammation by helminth-induced regulatory cells
    • Wilson, M.S. et al. Suppression of allergic airway inflammation by helminth-induced regulatory cells. J. Exp. Med. 202, 1199-1212.
    • J. Exp. Med , vol.202 , pp. 1199-1212
    • Wilson, M.S.1
  • 35
    • 34447498703 scopus 로고    scopus 로고
    • Heligmosomoides polygyrus infection down-regulates eot axin concentration and ccr3 expression on lung eosinophils in murine allergic pulmonary inflammation
    • Rzepecka, J., Donskow-Schmelter, K. & Doligalska, M. Heligmosomoides polygyrus infection down-regulates eot axin concentration and CCR3 expression on lung eosinophils in murine allergic pulmonary inflammation. Parasite Immunol. 29, 405-413 (2007).
    • (2007) Parasite Immunol , vol.29 , pp. 405-413
    • Rzepecka, J.1    Donskow-Schmelter, K.2    Doligalska, M.3
  • 36
    • 84866132091 scopus 로고    scopus 로고
    • Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth heligmosomoides polygyrus
    • McSorley, H.J. et al. Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. Eur. J. Immunol. 42, 2667-2682 (2012).
    • (2012) Eur. J. Immunol , vol.42 , pp. 2667-2682
    • McSorley, H.J.1
  • 37
    • 0024615261 scopus 로고
    • Suppression of heterologous immunity by nematospiroides dubuis antigens in vitro
    • Crawford, C., Behnke, J.M. & Pritchard, D.I. Suppression of heterologous immunity by Nematospiroides dubuis antigens in vitro. Int. J. Parasitol. 19, 29-34 (1989).
    • (1989) Int. J. Parasitol , vol.19 , pp. 29-34
    • Crawford, C.1    Behnke, J.M.2    Pritchard, D.I.3
  • 38
    • 0024619190 scopus 로고
    • Low-molecular-weight immunosuppressors secreted by adult nematospiroides dubuis
    • Monroy, F.G. , Dobson, C. & Adams, J.H. Low-molecular-weight immunosuppressors secreted by adult Nematospiroides dubuis. Int. J. Parasitol. 19, 125-127 (1989).
    • (1989) Int. J. Parasitol , vol.19 , pp. 125-127
    • Monroy, F.G.1    Dobson, C.2    Adams, J.H.3
  • 39
    • 0032424082 scopus 로고    scopus 로고
    • Heligmosomoides polygyrus immunomodulatory factor (imf) targets t-lymphocytes
    • Telford, G. et al. Heligmosomoides polygyrus immunomodulatory factor (IMF) targets T-lymphocytes. Parasite Immunol. 20, 601-611 (1998).
    • (1998) Parasite Immunol , vol.20 , pp. 601-611
    • Telford, G.1
  • 40
    • 43749120513 scopus 로고    scopus 로고
    • The secretome of the filarial parasite brugia malayi: Proteomic profile of adult excretory-secretory products
    • Hewitson, J.P. et al. The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products. Mol. Biochem. Parasitol. 160, 8-21 (2008).
    • (2008) Mol. Biochem. Parasitol , vol.160 , pp. 8-21
    • Hewitson, J.P.1
  • 41
    • 56249104176 scopus 로고    scopus 로고
    • Stage-and gender-specific proteomic analysis of brugia malayi excretory-secretory products
    • Moreno, Y. & Geary, T.G. Stage-And gender-specific proteomic analysis of Brugia malayi excretory-secretory products. PLoS Negl. Trop. Dis. 2, e326 (2008).
    • (2008) PLoS Negl. Trop. Dis , vol.2 , pp. e326
    • Moreno, Y.1    Geary, T.G.2
  • 42
    • 65549088510 scopus 로고    scopus 로고
    • Brugia malayi excreted/secreted proteins at the host/parasite interface: Stage-and gender-specific proteomic profiling
    • Bennuru, S. et al. Brugia malayi excreted/secreted proteins at the host/parasite interface: stage-And gender-specific proteomic profiling. PLoS Negl. Trop. Dis. 3, e3410 (2009).
    • (2009) PLoS Negl. Trop. Dis , vol.3 , pp. e3410
    • Bennuru, S.1
  • 43
    • 68649087906 scopus 로고    scopus 로고
    • An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen fasciola hepatica: Proteins associated with invasion and infection of the mamm alian host
    • Robinson, M.W. et al. An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mamm alian host. Mol. Cell. Proteomics 8, 1891-1907 (2009).
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 1891-1907
    • Robinson, M.W.1
  • 44
    • 0038608023 scopus 로고    scopus 로고
    • Comprehensive analysis of the secreted proteins of the parasite haemonchus contortus reveals extensive sequence variation and di fferential immune recognition
    • Yatsuda, A.P. et al. Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and di fferential immune recognition. J. Biol. Chem. 278, 16941-16951 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 16941-16951
    • Yatsuda, A.P.1
  • 45
    • 84883356595 scopus 로고    scopus 로고
    • Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity
    • Hewitson, J.P. et al. Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity. PLoS Pathog. 9, e1003492 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. e1003492
    • Hewitson, J.P.1
  • 46
    • 84887307315 scopus 로고    scopus 로고
    • Proteomic analysis of the excretory-secretory products from larval stages of ascaris suum reveals high abundance of glycosyl hydrolases
    • Wang, T. et al. Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases. PLoS Negl. Trop. Dis. 7, e2467 (2013).
    • (2013) PLoS Negl. Trop. Dis , vol.7 , pp. e2467
    • Wang, T.1
  • 47
    • 0001668777 scopus 로고
    • Eine einfache methode zur auffindung von ankylostomum (nematoden) larven in erdproben
    • Baerma nn, G. Eine einfache methode zur auffindung von Ankylostomum (nematoden) larven in erdproben. Geneesk. Tijdschr. Ned-Indië 57, 131-137 (1917).
    • (1917) Geneesk. Tijdschr. Ned-Indië , vol.57 , pp. 131-137
    • Baermann, G.1
  • 48
    • 78049285055 scopus 로고    scopus 로고
    • (revised edition Department of Nematology, Agricultural University, Wageningen, Holland
    • van Bezooijen, J. Methods and Techniques for Nematology (revised edition) (Department of Nematology, Agricultural University, Wageningen, Holland 2006).
    • (2006) Methods and Techniques for Nematology
    • Van Bezooijen, J.1
  • 49
    • 0033922732 scopus 로고    scopus 로고
    • Proteins secreted by the parasitic nematode nipp ostrongylus brasiliensis act as adjuvants for th2 responses
    • Holland, M.J., Harcus, Y.M., Riches, P.L. & Maizels, R.M. Proteins secreted by the parasitic nematode Nipp ostrongylus brasiliensis act as adjuvants for Th2 responses. Eur. J. Immunol. 30, 1977-1987 (2000).
    • (2000) Eur. J. Immunol , vol.30 , pp. 1977-1987
    • Holland, M.J.1    Harcus, Y.M.2    Riches, P.L.3    Maizels, R.M.4
  • 50
    • 0023472688 scopus 로고
    • Surface and excretory/secretory antigens of nematospiroides dubius
    • Adams, J.H., Monroy, F.G., East, J. & Dobson, C. Surface and excretory/secretory antigens of Nematospiroides dubius. Immuno. Cell Biol. 65, 393-397 (1987).
    • (1987) Immuno. Cell Biol , vol.65 , pp. 393-397
    • Adams, J.H.1    Monroy, F.G.2    East, J.3    Dobson, C.4
  • 51
    • 80555154812 scopus 로고    scopus 로고
    • Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes
    • Hewitson, J.P. et al. Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes. J. Immunol. 187, 4764-4777 (2011).
    • (2011) J. Immunol , vol.187 , pp. 4764-4777
    • Hewitson, J.P.1
  • 52
    • 0029862687 scopus 로고    scopus 로고
    • B cells solicit their own help from t cells
    • Stockinger, B. et al. B cells solicit their own help from T cells. J. Exp. Med. 183, 891-899 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 891-899
    • Stockinger, B.1
  • 53
    • 80052003701 scopus 로고    scopus 로고
    • The transcriptome of trichuris suis-first molecular insights into a parasite with curative properties for key immune diseases in humans
    • Cantacessi, C. et al. The transcriptome of Trichuris suis-first molecular insights into a parasite with curative properties for key immune diseases in humans. PLoS ONE 6, e23590 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e23590
    • Cantacessi, C.1
  • 54
    • 69549135695 scopus 로고    scopus 로고
    • Helminth products bypass the need for tslp in th2 immune responses by directly modulating dendritic cell function
    • Massacand, J.C.et al. Helminth products bypass the need for TSLP in TH2 immune responses by directly modulating dendritic cell function. Proc. Natl. Acad. Sci. USA 106, 13968-13973 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 13968-13973
    • Massacand, J.C.1
  • 55
    • 84873734722 scopus 로고    scopus 로고
    • Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated
    • Klaver, E.J. et al. Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated. Int. J. Parasitol. 43, 191-200 (2013).
    • (2013) Int. J. Parasitol , vol.43 , pp. 191-200
    • Klaver, E.J.1
  • 56
    • 0021750018 scopus 로고
    • Endotoxin contaminatio n of parenteral drugs and radiopharmaceuticals as determined by the limulus amebocyte lysate method
    • Twohy, C.W., Duran, A.P. & Munson, T.E. Endotoxin contaminatio n of parenteral drugs and radiopharmaceuticals as determined by the Limulus amebocyte lysate method. J. Parenter. Sci. Technol. 38, 190-201 (1984).
    • (1984) J. Parenter. Sci. Technol , vol.38 , pp. 190-201
    • Twohy, C.W.1    Duran, A.P.2    Munson, T.E.3
  • 58
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976).
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 59
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocytes-macrophage colony-stimulating factors
    • Inaba, K.M. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocytes-macrophage colony-stimulating factors. J. Exp. Med. 176, 1693-1702 (1992).
    • (1992) J. Exp. Med , vol.176 , pp. 1693-1702
    • Inaba, K.M.1
  • 60
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77-92 (1999).
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1


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