The role of ion channels and transporters in cell proliferation and cancer

Frontiers in Physiology

Volumn 4, Issue , 2013, Pages

  Becchetti, Andrea ^a   Munaron, Luca ^b   Arcangeli, Annarosa ^c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

cancer; cell cycle; ion channels; ion transporters; proliferation

Indexed keywords

EID: 84911476016     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00312     Document Type: Editorial

References (33)

1. Ambrosi, P., and Becchetti, A. (2013). Targeting neuronal nicotinic receptors in cancer: new ligands and potential side-effects. Recent Pat. Anticancer Drug Discov. 8, 38–52.
2. Arcangeli, A. (2005). Expression and role of hERG channels in cancer cells. Novartis Found. Symp. 266, 225–232. doi: 10.1002/047002142X. ch17
3. Arcangeli, A. (2011). Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk. Am.J.Physiol.CellPhysiol.301, C762–C771. doi: 10.1152/ajpcell.00113.2011
4. Arcangeli, A., and Becchetti, A. (2006). Complex functional interaction between integrin receptors and ion channels. Trends Cell Biol. 16, 631–639. doi: 10.1016/j.tcb.2006.10.003
5. Arcangeli, A., Crociani, O., Lastraioli, E., Masi, A., Pillozzi, S., and Becchetti, A. (2009). Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr. Med. Chem. 16, 66–93. doi: 10.2174/09298670978700 2835
6. Becchetti, A. (2011). Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer. Am.J.Physiol.CellPhysiol.301, C255–C265. doi: 10.1152/ajpcell.00047.2011
7. Becchetti, A., and Arcangeli, A. (2010). Integrins and ion channels in cell migration: implications for neuronal development, wound healing and metastatic spread. Adv. Exp. Med. Biol. 674, 107–123. doi: 10.1007/978-1-4419-6066-5_10
8. Binggeli, R., and Cameron, I. L. (1980). Cellular potentials of normal and cancerous fibroblasts and hepatocytes. Cancer Res. 40, 1830–1835.
9. + channels Kv1.3 and Kv1.5 in human cancer. Front. Physiol. 4:283. doi: 10.3389/fphys.2013.00283
10. Cone, C. D. (1974). The role of the surface electric transmembrane potential in normal and malignant mitogenesis. Ann. NY Acad. Sci. 238, 420–435. doi: 10.1111/j.1749-6632.1974.tb26808.x
11. Crottès, D., Guizouan, H., Martin, P., Borgese, F., and Soriani, O. (2013). The sigma-1 receptor: a regulator of cancer cell electrical plasticity? Front. Physiol. 4:175. doi: 10.3389/fphys.2013.00175
12. Csaderova, L., Debreova, M., Radvak, P., Stano, M., Vrestiakova, M., Kopacek, J., et al. (2013). The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration. Front. Physiol. 4:271. doi: 10.3389/fphys.2013. 00271
13. + channel in mouse early embryos. Nature 365, 560–562. doi: 10.1038/365560a0
14. + channels in human T lymphocytes: a role in mitogenesis? Nature 307, 465–468. doi: 10.1038/307465a0
15. Egleton, R. D., Brown, K. C., and Dasgupta, P. (2008). Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol. Sci. 29, 151–158. doi: 10.1016/j.tips.2007.12.006
16. Fiorio Pla, A., Avanzato, D., Munaron, L., and Ambudkar, I. S. (2012). Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets. Am.J.Physiol.CellPhysiol.302, C9–C15. doi: 10.1152/ajp-cell.00280.2011
17. Fiorio Pla, A., and Gkika, D. (2013). Emerging role of TRP channels in cell migration: from tumor vascularisation to metastasis. Front. Physiol. 4:311. doi: 10.3389/fphys.2013.00311
18. Hegle, A. P., Marble, D. D., and Wilson, G. F. (2006). A voltage-driven switch for ion-independent signaling by ether-á-go-go K+ channel. Proc. Natl. Acad. Sci. USA 103, 2886–2891. doi: 10.1073/pnas.0505909103
19. V 10.1. Front. Physiol. 4:201. doi: 10.3389/fphys.2013.00201
20. Huber, S. M., Butz, L., Stegen, B., Klumpp, D., Braun, N., Ruth, P., et al. (2013). Ionizing radiation, ion transports, and radioresistance of cancer cells. Front. Physiol. 4:212. doi: 10.3389/fphys.2013.00212
21. Improgo, M. R., Soll, L. G., Tapper, A. R., and Gardner, P. D. (2013). Nicotinic acetylcholine receptors mediate lung cancer growth. Front. Physiol. 4:251. doi: 10.3389/fphys.2013.00251
22. Kondratskyi, A., Yassine, M., Kondratska, K., Skryma, R., Slomianny, C., and Prevarskaya, N. (2013). Calcium-permeable ion channels in control of autophagy and cancer. Front. Physiol. 4:272. doi: 10.3389/fphys.2013. 00272
23. Leanza, L., Biasutto, L.., Managò, A., Gulbins, E., Zoratti, M., and Szabò, I. (2013). Intracellular ion channels and cancer. Front. Physiol. 4:227. doi: 10.3389/fphys.2013.00227
24. Lehen’kyi, V., Shapovalov, G., Skryma, R., and Prevarskaya, N. (2011). Ion channels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis. Am.J.Physiol.CellPhysiol. 301, C1281–C1289.
25. Monti, S. M., Supuran, C. T., and De Simone, G. (2012). Carbonic anhydrase IX as a target for designing novel anticancer drugs. Curr.Med.Chem. 19, 821–830. doi: 10.2174/092986712799034851
26. Munaron, L. (2012). Intracellular calcium signaling: holding the balance between health and disease. Curr. Med. Chem. 19, 5765–5767. doi: 10.2174/092986712804143330
27. + channels and cell cycle progression in tumor cells. Front. Physiol. 4:220. doi: 10.3389/fphys.2013.00220
28. Pardo, L. A., and Stühmer, W. (2008). Eag1: an emerging oncological target. Cancer Res. 68, 1611–1613. doi: 10.1158/0008-5472.CAN-07-5710
29. Pedersen, S. F., Hoffmann, E. K., and Novak, I. (2013). Cell volume regulation in epithelial physiology and cancer. Front. Physiol. 4:233. doi: 10.3389/fphys.2013.00233
30. Rizzuto, R., De Stefani, D., Raffaello, A., and Mammucari, C. (2012). Mitochondria as sensors and regulators of calcium signalling. Nat. Rev. Mol. Cell. Biol. 13, 566–578. doi: 10.1038/nrm3412
31. 2+ for cancer cell proliferation and survival. Nat. Rev. Cancer 8, 361–375. doi: 10.1038/nrc2374
32. Schuller, H. M. (2009). Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat. Rev. Cancer 9, 195–205. doi: 10.1038/nrc 2590
33. Yang, M., and Brackenbury, W. J. (2013). Membrane potential and cancer progression. Front. Physiol. 4:185. doi: 10.3389/fphys.2013.00185