MicroRNA let-7g and let-7i inhibit hepatoma cell growth concurrently via downregulation of the anti-apoptoticprotein B-cell lymphoma-extra large

Oncology Letters

Volumn 9, Issue 1, 2015, Pages 213-218

  Wu, Lingjiao ^a   Wang, Qiangfeng ^b   Yao, Jian ^a   Jiang, Han ^b   Xiao, Cheng ^b   Wu, Fusheng ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Anti apoptotic protein; Apoptosis; Coordinately; Hepatocellular carcinoma; miR let 7g i

Indexed keywords

MICRORNA; MICRORNA LET 7G; MICRORNA LET 7I; PROTEIN BCL XL; UNCLASSIFIED DRUG;

5 ETHYNYL 2 DEOXYURIDINE RETENTION ASSAY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; DRUG EFFECT; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84911441285     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2706     Document Type: Article

References (27)

1. Lujambio A and Lowe SW: The microcosmos of cancer. Nature 482: 347-355, 2012.
2. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
3. Roush S and Slack FJ: The let-7 family of microRNAs. Trends Cell Biol 18: 505-516, 2008.
4. Esquela-Kerscher A and Slack FJ: Oncomirs -microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
5. Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512, 2005.
6. Hou J, Lin L, Zhou W, et al: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19: 232-243, 2011.
7. Yanaihara N, Caplen N, Bowman E, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198, 2006.
8. Akao Y, Nakagawa Y and Naoe T: let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29: 903-906, 2006.
9. Nam EJ, Yoon H, Kim SW, et al: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 14: 2690-2695, 2008.
10. Peng Y, Laser J, Shi G, et al: Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res 6: 663-673, 2008.
11. Shimizu S, Takehara T, Hikita H, et al: The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol 52: 698-704, 2010.
12. Zhu XM, Wu LJ, Xu J, Yang R and Wu FS: Let-7c microRNA expression and clinical significance in hepatocellular carcinoma. J Int Med Res 39: 2323-2329, 2011.
13. Hu X, Guo J, Zheng L, et al: The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Mol Cancer Res 11: 240-250, 2013.
14. Doench JG and Sharp PA: Specificity of microRNA target selection in translational repression. Genes Dev 18: 504-511, 2004.
15. Brennecke J, Stark A, Russell RB and Cohen SM: Principles of microRNA-target recognition. PLoS Biol 3: e85, 2005.
16. Abbott AL, Alvarez-Saavedra E, Miska EA, et al: The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell 9: 403-414, 2005.
17. Johnson CD, Esquela-Kerscher A, Stefani G, et al: The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67: 7713-7722, 2007.
18. Inui M, Martello G and Piccolo S: MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11: 252-263, 2010.
19. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006.
20. Nicoloso MS, Spizzo R, Shimizu M, Rossi S and Calin GA: MicroRNAs-the micro steering wheel of tumour metastases. Nat Rev Cancer 9: 293-302, 2009.
21. Hunter SE, Finnegan EF, Zisoulis DG, et al: Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans. PLoS Genet 9: e1003353, 2013.
22. Murray MJ, Saini HK, Siegler CA, et al: LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res 73: 4872-4884, 2013.
23. Bueno MJ, Gomez de Cedron M, Gomez-Lopez G, et al: Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood 117: 6255-6266, 2011.
24. Mayr C, Hemann MT and Bartel DP: Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315: 1576-1579, 2007.
25. Johnson SM, Grosshans H, Shingara J, et al: RAS is regulated by the let-7 microRNA family. Cell 120: 635-647, 2005.
26. Tsang WP and Kwok TT: Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3. Apoptosis 13: 1215-1222, 2008.
27. Watanabe J, Kushihata F, Honda K, et al: Prognostic significance of Bcl-xL in human hepatocellular carcinoma. Surgery 135: 604-612, 2004.