Anti-smoking legislation and its effects on urinary cotinine and cadmium levels

Environmental Research

Volumn 136, Issue , 2015, Pages 227-233

  Sánchez Rodríguez, Jinny E ^a   Bartolomé, Mónica ^a   Cañas, Ana I ^a   Huetos, Olga ^a   Navarro, Carmen ^a   Rodríguez, A Carolina ^a   Arribas, Misericordia ^b   Esteban, Marta ^a   López, Ana ^a   Castaño, Argelia ^a  

^a Instituto de Salud Carlos III   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Cadmium; Cotinine; Human biomonitoring; Second hand smoke (SHS); Smoke free policy

Indexed keywords

CADMIUM; COTININE; CREATININE;

BIOCHEMICAL COMPOSITION; CADMIUM; EXCRETION; POLICY MAKING; SMOKING; TOXICOLOGY; URINE;

ADULT; ARTICLE; BODY BURDEN; CONTROLLED STUDY; CREATININE URINE LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PASSIVE SMOKING; SELF REPORT; SMOKING; SMOKING BAN; SPAIN; URINALYSIS; URINARY CADMIUM LEVEL; URINARY COTININE LEVEL; URINE LEVEL; WORK ENVIRONMENT; LEGISLATION AND JURISPRUDENCE; URINE;

MADRID [SPAIN]; SPAIN;

CADMIUM; COTININE; FEMALE; HUMANS; MALE; SMOKING; SPAIN;

EID: 84911428932     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.09.033     Document Type: Article

References (53)

1. Adams S.V., Passarelli M.N., Newcom P.A. Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. Occup. Environ. Med. 2012, 69:153-156.
2. Akerstrom M., Barregard L., Lundh T., Sallsten G. Variability of urinary cadmium excretion in spot urine samples, first morning voids, and 24h urine in a in a healthy non-smoking population: implications for study design. J. Expos. Sci. Environ. Epidemiol. 2014, 24:171-179.
3. ATSDR (Agency for Toxic Substances and Disease Registry) Toxicological Profile for Cadmium 2012, U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA.
4. Bartolomé M., Gallego-Picó A., Huetos O., Castaño A. High-performance liquid chromatography with diode-array detection cotinine method adapted for the assessment of tobacco smoke exposure. J. Sep. Sci. 2014, 7pp. 10.1002/jssc.201301259.
5. Becker K., Conrad A., Kirsch N., Kolossa-Gehring M., Schulz C., Seiwert M., Seifert B. German Environmental Survey (GerES): human biomonitoring as a tool to identify exposure pathways. Int. J. Hyg. Environ. Health 2007, 210:267-269.
6. Budisavljevic M.N., Ploth D.W. Nicotine and the kidney: Mr. Hyde, and perhaps some Dr. Jekyll. Am. J. Physiol. Renal. Physiol. 2012, 302:F1082-F1083.
7. Callinan J.E., Clarke A., Doherty K., Kelleher C. Legislative smoking bans for reducing secondhand smoke exposure, smoking prevalence and tobacco consumption. Cochrane Database Syst. Rev. 2010, 4:CD005992. 10.1002/14651858.CD005992.pub2.
8. Cañas A.I., Esteban M., Cutanda F., Castaño A. Risk of overestimation of urinary cadmium concentrations: interference from molybdenum. E3S Web Conf. 2013, 1:21003. 10.1051/e3sconf/20130121003.
9. Castaño A., Sánchez-Rodríguez J.E., Cañas A., Esteban M., Navarro C., Rodríguez-García A.C., Arribas M., Díaz G., Jiménez-Guerrero J.A. Mercury, lead and cadmium levels in the urine of 170 Spanish adults: a pilot human biomonitoring study. Int. J. Hyg. Environ. Health 2012, 215:191-195.
10. Chaumont A., Voisin C., Deumer G., Haufroid V., Annesi-Maesano I., Roels H., et al. Associations of urinary cadmium with age and urinary proteins: further evidence of physiological variations unrelated to metal accumulation and toxicity. Environ. Health Perspect. 2013, 121:1047-1053.
11. CDC (Centers for Disease Control and Prevention), 2013. Smoking and Tobacco Use. Available from: (accessed 18.07.13). http://www.cdc.gov/tobacco/index.htm.
12. Ciesielski T., Weuve J., Bellinger D.C., Schwartz J., Lanphear B., Wright R.O. Cadmium exposure and neurodevelopmental outcomes in U.S. children. Environ. Health Perspect. 2012, 120:758-763.
13. Córdoba R., Nerín I., Galindo V., Alayeto C., Villaverde-Royo M.V., Sanz C. Impacto de la nueva legislación sobre tabaquismo (Ley 42/2010) en los niveles de humo ambiental de tabaco en locales de hostelería. Gac. Sanit. 2013, 27:161-163.
14. Dülger H., Dönder A., Sekeroğlu M.R., Erkoç R., Ozbay B. Investigation of the relationship between serum levels of cotinine and the renal function in active and passive smokers. Ren. Fail. 2011, 33:475-479.
15. EFSA (European Food Safety Authority) Scientific opinion on cadmium in food. The EFSA J. 2009, 980:1-139.
16. Evans K.A., Sims M., Judge K., Gilmore A. Assessing the knowledge of the potential harm to others caused by second-hand smoke and its impact on protective behaviours at home. J. Public Health (Oxf.) 2012, 34:183-194.
17. Galán I., Mata N., Estrada C., Díez-Gañán L., Velázquez L., Zorrilla B., et al. Impact of the "Tobacco control law" on exposure to environmental tobacco smoke in Spain. BMC Public Health 2007, 7:224.
18. Gunier R.B., Horn-Ross P.L., Canchola A.J., Duffy C.N., Reynolds P., Hertz A., et al. Determinants and within-person variability of urinary cadmium concentrations among women in northern California. Environ. Health Perspect. 2013, 121:643-649.
19. Hahn E.J. Smokefree legislation: a review of health and economic outcomes research. Am. J. Prev. Med. 2010, 39:S66-S76.
20. Hornung R.W., Reed L.D. Estimation of average concentration in the presence of non-detectable values. Appl. Occup. Environ. Hyg. 1990, 5:46-51.
21. IARC (International Agency for Research on Cancer), 2013. Agents Classified by the IARC Monographs, vols. 1-109. Lyon, France. Available from: (accessed 12.11.13). http://monographs.iarc.fr/ENG/Classification/.
22. INE (Instituto Nacional de Estadística), 2013. Encuesta Nacional de Salud 2011-2012. Available from: (accessed 05.05.13). http://www.ine.es.
23. Institute of Medicine Secondhand Smoke Exposure and Cardiovascular Effects: Making Sense of the Evidence 2009, National Academy of Sciences, Washington, (accessed 12.06.13).
24. Järup L., Åkesson A. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol. 2009, 238:201-208.
25. Jatlow P., McKee S., O'Malley S.S. Correction of urine cotinine concentrations for creatinine excretion: is it useful?. Clin. Chem. 2003, 49:1932-1934.
26. Kabir Z, Clarke V, Conroy R, McNamee E, Daly S, Clancy L. Low birthweight and preterm birth rates 1 year before and after the Irish workplace smoking ban. BJOG 2009, 116:1782-1787.
27. Karmaus W., Dimitrov P., Simeonov V., Tsolova S., Bonev A., Georgieva R. Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study. Environ. Health 2008, 7:11. 10.1186/1476-069X-7-11.
28. Kippler M., Tofail F., Gardner R., Rahman A., Hamadani J.D., Bottai M., Vahter M. Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study. Environ. Health Perspect. 2012, 120:284-289.
29. Lampe B.J., Park S.K., Robins T., Mukherjee B., Litonjua A.A., Amarasiriwardena C., et al. Association between 24-hour urinary cadmium and pulmonary function among community-exposed men: the VA Normative Aging Study. Environ. Health Perspect. 2008, 116:1226-1230.
30. Madrid, 2011. Calidad del aire. Dirección General de Sostenibilidad, Servicio de Protección de la Atmosfera. Área de Gobierno de Medio Ambiente, Seguridad y Movilidad, Municipio de Madrid, Spain, pp. 61.
31. Mannino D.M., Holguin F., Greves H.M., Savage-Brown A., Stock A.L., Jones R.L. Urinary cadmium levels predict lower lung function in current and former smokers: data from the Third National Health and Nutrition Examination Survey. Thorax 2004, 59:194-198.
32. McElroy J.A., Shafer M.M., Trentham-Dietz A., Hampton J.M., Newcomb P.A. Cadmium exposure and breast cancer risk. J. Natl. Cancer Inst. 2006, 98:869-873.
33. McElroy J.A., Shafer M.M., Trentham-Dietz A., Hampton J.M., Newcomb P.A. Urinary cadmium levels and tobacco smoke exposure in women age 20-69 years in the United States. J. Toxicol. Environ. Health A 2007, 70:1779-1782.
34. Menke A., Muntner P., Silbergeld E.K., Platz E.A., Guallar E. Cadmium levels in urine and mortality among U.S. adults. Environ. Health Perspect. 2009, 117:190-196.
35. Miller M., Moses A.M. Drug-induced states of impaired water excretion. Kidney Int. 1976, 10:96-103.
36. Navas-Acien A., Selvin E., Sharrett A.R., Calderon-Aranda E., Silbergeld E., Guallar E. Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 2004, 109:3196-3201.
37. Nebot M., López M.J., Ariza C., Pérez-Ríos M., Fu M., Schiaffino A., et al. Impact of the Spanish smoking law on exposure to secondhand smoke in offices and hospitality venues: before-and-after study. Environ. Health Perspect. 2009, 117:344-347.
38. O'Connor T.Z., Holford T.R., Leaderer B.P., Hammond S.K., Bracken MB. Measurement of exposure to environmental tobacco smoke in pregnant women. Am. J. Epidemiol. 1995, 142:1315-1321.
39. Orth S.R. Smoking and the kidney. J. Am. Soc. Nephrol. 2002, 13:1663-1672.
40. Razi C.H., Akin K.O., Harmanci K., Ozdemir O., Abaci A., Hizli S., et al. Relationship between hair cadmium levels, indoor ETS exposure and wheezing frequency in children. Allergol. Immunopathol. (Madr.) 2012, 40:51-59.
41. Richter P.A., Bishop E.E., Wang J., Swahn M.H. Tobacco smoke exposure and levels of urinary metals in theU.S. youth and adult population: the National Health and Nutrition Examination Survey (NHANES) 1999-2004. Int. J. Environ. Res. Public Health 2009, 6:1930-1946.
42. Riederer A.M., Belova A., George B.J., Anastas P.T. Urinary cadmium in the 1999-2008 U.S. National and Nutrition Examination Survey (NHANES). Environ. Sci. Technol. 2013, 47:1137-1147.
43. Satarug S., Moore M.R. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect. 2004, 112:1099-1103.
44. Satarug S., Nishijo M., Ujjin P., Vanavanitkun Y., Baker J.R., Moore M.R. Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. Toxicol. Lett. 2004, 148:187-197.
45. Satarug S., Garrett S.H., Sens M.A., Sens D.A. Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 2010, 118:182-190.
46. Shaham J., Meltzer A., Ashkenazi R., Ribak J. Biological monitoring of exposure to cadmium, a human carcinogen, as a result of active and passive smoking. J. Occup. Environ. Med. 1996, 38:1220-1228.
47. Sims M., Maxwell R., Gilmore A. Short-term impact of the smokefree legislation in England on emergency hospital admissions for asthma among adults: a population-based study. Thorax 2013, 68:619-624.
48. SRNT Subcommittee on Biochemical Verification Biochemical verification of tobacco use and cessation. Nicotine Tob. Res. 2002, 4:149-159.
49. Tellez-Plaza M., Navas-Acien A., Caldwell K.L., Menke A., Muntner P., Guallar E. Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates. Environ. Health Perspect. 2012, 120:204-209.
50. Tellez-Plaza M., Navas-Acien A., Menke A., Crainiceanu C.M., Pastor-Barriuso R., Guallar E. Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population. Environ. Health Perspect. 2012, 120:1017-1022.
51. WMA (World Medical Association) Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. 2008, World Medical Association, France.
52. Wong L.T., Smyth D.D., Sitar D.S. Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers. J. Pharmacol. Exp. Ther. 1992, 261:21-25.
53. Wu D, Landsberger S, Larson SM. Evaluation of elemental cadmium as a marker for environmental tobacco smoke. Environ. Sci. Technol. 1995, 29:2311-2316.