Notch intracellular domain deficiency in nuclear localization activity retains the ability to enhance neural stem cell character and block neurogenesis in mammalian brain development

Stem Cells and Development

Volumn 23, Issue 23, 2014, Pages 2841-2850

  Jang, Jiwon ^a   Byun, Sung Hyun ^b   Han, Dasol ^b   Lee, Junsub ^a   Kim, Juwan ^b   Lee, Nayeon ^b   Kim, Inhee ^b   Park, Soojeong ^b   Ha, Soobong ^b   Kwon, Mookwang ^b   Ahn, Jyhyun ^a   Chung, Woo Jae ^b   Kweon, Dae Hyuk ^b   Cho, Jae Youl ^b   Kim, Sunyoung ^a   Yoon, Keejung ^b  

^a Seoul National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; NOTCH RECEPTOR; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; NUCLEAR LOCALIZATION SIGNAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CARCINOGENESIS; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTANT; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PROTEIN DOMAIN; REAL TIME POLYMERASE CHAIN REACTION; 3T3 CELL LINE; ANIMAL; BRAIN; CELL NUCLEUS; EMBRYOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

MAMMALIA;

ANIMALS; ANKYRIN REPEAT; BRAIN; CELL NUCLEUS; MICE; NEURAL STEM CELLS; NEUROGENESIS; NIH 3T3 CELLS; NUCLEAR LOCALIZATION SIGNALS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 84911417019     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0031     Document Type: Article

References (28)

1. Mizutani K-I, K Yoon, L Dang, A Tokunaga and N Gaiano. (2007). Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 449:351-355.
2. Yoon K, S Nery, ML Rutlin, F Radtke, G Fishell and N Gaiano. (2004). Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24:9497-9506.
3. Yoon K and N Gaiano. (2005). Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci 8:709-715.
4. Penton AL, LD Leonard and NB Spinner. (2012). Notch signaling in human development and disease. Semin Cell Dev Biol 23:450-457.
5. Kopan R and MX Ilagan. (2009). The canonical Notch signaling pathway: Unfolding the activation mechanism. Cell 137:216-233.
6. Kovall RA and SC Blacklow. (2010). Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol 92:31-71.
7. Diévart A, N Beaulieu and P Jolicoeur. (1999). Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 18:5973-5981.
8. Beatus P, J Lundkvist, C Oberg, K Pedersen and U Lendahl. (2001). The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. Mech Dev 104:3-20.
9. Deregowski V, E Gazzerro, L Priest, S Rydziel and E Canalis. (2006). Role of the Ram domain and ankyrin repeats on Notch signaling and activity in cells of osteoblastic lineage. J Bone Miner Res 21:1317-1326.
10. Kopan R, JS Nye and H Weintraub. (1994). The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120: 2385-2396.
11. Jeffries S and AJ Capobianco. (2000). Neoplastic transformation by Notch requires nuclear localization. Mol Cell Biol 20:3928-3941.
12. Aster JC, ES Robertson, RP Hasserjian, JR Turner, E Kieff and J Sklar. (1997). Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem 272: 11336-11343.
13. Oishi K, S Kamakura, Y Isazawa, T Yoshimatsu, K Kuida, M Nakafuku, N Masuyama and Y Gotoh. (2004). Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis. Dev Biol 276:172-184.
14. Nofziger D, A Miyamoto, KM Lyons and G Weinmaster. (1999). Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development 126: 1689-1702.
15. Dumont E, KP Fuchs, G Bommer, B Christoph, E Kremmer and B Kempkes. (2000). Neoplastic transformation by Notch is independent of transcriptional activation by RBPJkappa signalling. Oncogene 19:556-561.
16. Jang J, J Lee, S-T Kim, K-Y Lee, JY Cho, D-H Kweon, S-T Kwon, YH Koh, S Kim and K Yoon. (2012). Polycationmediated enhancement of retroviral transduction efficiency depends on target cell types and pseudotyped Env proteins: implication for gene transfer into neural stem cells. Neurochem Int 60:846-851.
17. Hsieh JJ, T Henkel, P Salmon, E Robey, MG Peterson and SD Hayward. (1996). Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 16:952-959.
18. Takebayashi K, Y Sasai, Y Sakai, T Watanabe, S Nakanishi and R Kageyama. (1994). Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helixloop-helix factor HES-1. J Biol Chem 269:5150-5156.
19. Hayashi H and T Kume. (2008). Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS One 3:e2401.
20. Yang M-S, J-S Hong, S-T Kim, K-Y Lee, KW Park, S-T Kwon, D-H Kweon, YH Koh, N Gaiano and K Yoon. (2011). Among gamma-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer selfrenewal properties to neural stem cells. Biochem Biophys Res Commun 404:133-138.
21. Gaiano N, JS Nye and G Fishell. (2000). Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 26:395-404.
22. Wen W, JL Meinkotht, RY Tsien and SS Taylor. (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82:463-473.
23. Snyder EY, DL Deitcher, C Walsh, S Arnold-Aldea, EA Hartwieg and CL Cepko. (1992). Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 68:33-51.
24. Hirata H, S Yoshiura, T Ohtsuka, Y Bessho, T Harada, K Yoshikawa and R Kageyama. (2002). Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298:840-843.
25. Le Gall M and E Giniger. (2004). Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila Notch. J Biol Chem 279:29418-29426.
26. Androutsellis-Theotokis A, RR Leker, F Soldner, DJ Hoeppner, R Ravin, SW Poser, MA Rueger, S-K Bae, R Kittappa and RDG McKay. (2006). Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442:823-826.
27. Perumalsamy LR, M Nagala, P Banerjee and A Sarin. (2009). A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells. Cell Death Differ 16:879-889.
28. Hurlbut GD, MW Kankel, RJ Lake and S Artavanis-Tsakonas. (2007). Crossing paths with Notch in the hypernetwork. Curr Opin Cell Biol 19:166-175.