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Volumn 7, Issue 6, 2014, Pages 841-857

Current and emerging monoclonal antibody treatments for chronic lymphocytic leukemia: State of the art

Author keywords

CD19; CD20; CD23; CD37; CD40; CD52; CLL; Dacetuzumab; GA 101; Lucatumumab; Lumiliximab; MOR208; Ocrelizumab; Ofatumumab; Otlertuzumab; TRU 016; Veltuzumab

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; BI 836826; CD19 ANTIBODY; CD19 ANTIGEN; CD20 ANTIGEN; CD37 ANTIGEN; CD40 ANTIGEN; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; DACETUZUMAB; DEXAMETHASONE; FLUDARABINE; GBR 401; IBRUTINIB; LUCATUMUMAB; LUMILIXIMAB; MEDI 551; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD37; MONOCLONAL ANTIBODY CD40; OBINUTUZUMAB; OCARATUZUMAB; OFATUMUMAB; OTLERTUZUMAB; PREDNISONE; RITUXIMAB; UNCLASSIFIED DRUG; VELTUZUMAB; CD37 PROTEIN, HUMAN; TETRASPANIN; TUMOR ANTIGEN;

EID: 84911399022     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/17474086.2014.963048     Document Type: Review
Times cited : (13)

References (137)
  • 1
    • 84871499151 scopus 로고    scopus 로고
    • Emerging monoclonal antibodies and related agents for the treatment of chronic lymphocytic leukemia
    • Robak T. Emerging monoclonal antibodies and related agents for the treatment of chronic lymphocytic leukemia. Future Oncol 2013;9:69-91
    • (2013) Future Oncol , vol.9 , pp. 69-91
    • Robak, T.1
  • 2
    • 78651376557 scopus 로고    scopus 로고
    • New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies
    • Robak T, Robak E. New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies. BioDrugs 2011;25:13-25
    • (2011) BioDrugs , vol.25 , pp. 13-25
    • Robak, T.1    Robak, E.2
  • 3
    • 77950331000 scopus 로고    scopus 로고
    • CD20 as a target for therapeutic type i and II monoclonal antibodies
    • Beers SA, Chan CH, French RR, et al. CD20 as a target for therapeutic type I and II monoclonal antibodies. Semin Hematol 2010;47:107-14
    • (2010) Semin Hematol , vol.47 , pp. 107-114
    • Beers, S.A.1    Chan, C.H.2    French, R.R.3
  • 4
    • 0034951864 scopus 로고    scopus 로고
    • Mechanism of action of rituximab
    • Maloney DG. Mechanism of action of rituximab. Anticancer Drugs 2001; 12(Suppl 2):1-4
    • (2001) Anticancer Drugs , vol.12 , pp. 1-4
    • Maloney, D.G.1
  • 5
    • 66149185427 scopus 로고    scopus 로고
    • An imaging-based rapid evaluation method for complement-dependent cytotoxicity discriminated clinical response to rituximab-containing chemotherapy
    • Mishima Y, Sugimura N, Matsumoto-Mishima Y, et al. An imaging-based rapid evaluation method for complement-dependent cytotoxicity discriminated clinical response to rituximab-containing chemotherapy. Clin Cancer Res 2009;15:3624-32
    • (2009) Clin Cancer Res , vol.15 , pp. 3624-3632
    • Mishima, Y.1    Sugimura, N.2    Matsumoto-Mishima, Y.3
  • 7
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 2000;6:443-6
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 8
    • 84859833070 scopus 로고    scopus 로고
    • Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway
    • Honeychurch J, Alduaij W, Azizyan M, et al. Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway. Blood 2012;119:3523-33
    • (2012) Blood , vol.119 , pp. 3523-3533
    • Honeychurch, J.1    Alduaij, W.2    Azizyan, M.3
  • 9
    • 84859402731 scopus 로고    scopus 로고
    • Exhaustion of cytotoxic effector systems may limit monoclonal antibody-based immunotherapy in cancer patients
    • Beurskens FJ, Lindorfer MA, Farooqui M, et al. Exhaustion of cytotoxic effector systems may limit monoclonal antibody-based immunotherapy in cancer patients. J Immunol 2012;188:3532-41
    • (2012) J Immunol , vol.188 , pp. 3532-3541
    • Beurskens, F.J.1    Lindorfer, M.A.2    Farooqui, M.3
  • 10
    • 80053080677 scopus 로고    scopus 로고
    • Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells
    • Beum PV, Peek EM, Lindorfer MA, et al. Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells. J Immunol 2011;187:3438-47
    • (2011) J Immunol , vol.187 , pp. 3438-3447
    • Beum, P.V.1    Peek, E.M.2    Lindorfer, M.A.3
  • 11
    • 77954679392 scopus 로고    scopus 로고
    • Antigenic modulation limits the efficacy of anti-CD20 antibodies: Implications for antibody selection
    • Beers SA, French RR, Chan HT, et al. Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood 2010;115: 5191-201
    • (2010) Blood , vol.115 , pp. 5191-5201
    • Beers, S.A.1    French, R.R.2    Chan, H.T.3
  • 12
    • 84894078151 scopus 로고    scopus 로고
    • Inhibitory FcgRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity
    • Vaughan AT, Iriyama C, Beers SA, et al. Inhibitory FcgRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity. Blood 2014;123:669-77
    • (2014) Blood , vol.123 , pp. 669-677
    • Vaughan, A.T.1    Iriyama, C.2    Beers, S.A.3
  • 13
    • 0037251878 scopus 로고    scopus 로고
    • Rituximab: A review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia
    • Plosker GL, Figgitt DP. Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs 2003;63:803-43
    • (2003) Drugs , vol.63 , pp. 803-843
    • Plosker, G.L.1    Figgitt, D.P.2
  • 14
    • 84893009815 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of rituximab: Pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys
    • Mao CP, Brovarney MR, Dabbagh K, et al. Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys. PLoS One 2013;8(11):e80533
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e80533
    • Mao, C.P.1    Brovarney, M.R.2    Dabbagh, K.3
  • 15
    • 77958588509 scopus 로고    scopus 로고
    • Hepatitis B reactivation and rituximab in the oncology practice
    • Villadolid J, Laplant KD, Markham MJ, et al. Hepatitis B reactivation and rituximab in the oncology practice. Oncologist 2010;15:1113-21
    • (2010) Oncologist , vol.15 , pp. 1113-1121
    • Villadolid, J.1    Laplant, K.D.2    Markham, M.J.3
  • 16
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164-74
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 17
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol 2010;28:1756-65
    • (2010) J Clin Oncol , vol.28 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 18
    • 84858664440 scopus 로고    scopus 로고
    • Rituximab for chronic lymphocytic leukemia
    • Robak T. Rituximab for chronic lymphocytic leukemia. Expert Opin Biol Ther 2012;12:503-15
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 503-515
    • Robak, T.1
  • 19
    • 0034043849 scopus 로고    scopus 로고
    • Successful treatment and re-treatment of resistant B-cell chronic lymphocytic leukemia with the monoclonal anti-CD20 antibody rituximab
    • Herold M, Schulze A, Hartwig K, Anger G. Successful treatment and re-treatment of resistant B-cell chronic lymphocytic leukemia with the monoclonal anti-CD20 antibody rituximab. Ann Hematol 2000;79:332-5
    • (2000) Ann Hematol , vol.79 , pp. 332-335
    • Herold, M.1    Schulze, A.2    Hartwig, K.3    Anger, G.4
  • 20
    • 0036757311 scopus 로고    scopus 로고
    • Standard dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: Results from a Nordic multicentre study
    • Itala M, Geisler CH, Kimby E, et al. Standard dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: results from a Nordic multicentre study. Eur J Haematol 2002;69:129-34
    • (2002) Eur J Haematol , vol.69 , pp. 129-134
    • Itala, M.1    Geisler, C.H.2    Kimby, E.3
  • 21
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab dose-escalation trial in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol 2001;19:2165-70
    • (2001) J Clin Oncol , vol.19 , pp. 2165-2170
    • O'Brien, S.M.1    Kantarjian, H.2    Thomas, D.A.3
  • 22
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 2001;19:2153-64
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 23
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Barton JH, et al. Single-agent rituximab as first line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2003;21:1746-51
    • (2003) J Clin Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 24
    • 79959995569 scopus 로고    scopus 로고
    • Experience with rituximab immunotherapy as an early intervention in patients with Rai stage 0 to II chronic lymphocytic leukemia
    • Ferrajoli A, Keating MJ, O'Brien S, et al. Experience with rituximab immunotherapy as an early intervention in patients with Rai stage 0 to II chronic lymphocytic leukemia. Cancer 2011;117:3182-6
    • (2011) Cancer , vol.117 , pp. 3182-3186
    • Ferrajoli, A.1    Keating, M.J.2    O'Brien, S.3
  • 25
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent vs sequential treatment with rituximab in symptomatic untreated patients with B-cell chronic lymphocytic leukemia results from Cancer and Leukemia Group B 9712 (CALG B9712)
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent vs sequential treatment with rituximab in symptomatic untreated patients with B-cell chronic lymphocytic leukemia results from Cancer and Leukemia Group B 9712 (CALG B9712). Blood 2003;101:6-14
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 26
    • 77958061246 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide or other agents in chronic lymphocytic leukemia
    • Robak T, Lech-Maranda E, Robak P. Rituximab plus fludarabine and cyclophosphamide or other agents in chronic lymphocytic leukemia. Expert Rev Anticancer Ther 2010;10:1529-43
    • (2010) Expert Rev Anticancer Ther , vol.10 , pp. 1529-1543
    • Robak, T.1    Lech-Maranda, E.2    Robak, P.3
  • 27
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005;23:4079-88
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 28
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 2008;112:975-80
    • (2008) Blood , vol.112 , pp. 975-980
    • Tam, C.S.1    O'Brien, S.2    Wierda, W.3
  • 29
    • 59449110380 scopus 로고    scopus 로고
    • Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia
    • Tsimberidou AM, Tam C, Abruzzo LV, et al. Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia. Cancer 2009;115:373-80
    • (2009) Cancer , vol.115 , pp. 373-380
    • Tsimberidou, A.M.1    Tam, C.2    Abruzzo, L.V.3
  • 30
    • 84878898569 scopus 로고    scopus 로고
    • Extended follow up of the CLL8 protocol a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): Results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen
    • Fischer K, Bahlo J, Fink A-M, et al. Extended follow up of the CLL8 protocol, a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): Results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen. Blood (ASH Annual Meeting Abstracts) 2012;120:abstract 435
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Fischer, K.1    Bahlo, J.2    Fink, A.-M.3
  • 31
    • 84898762881 scopus 로고    scopus 로고
    • Early versus deferred treatment with combined fludarabine, cyclophosphamide and rituximab (FCR) improves event-free survival in patients with high-risk Binet stage A chronic lymphocytic leukemia-First results of a randomized German-French Cooperative Phase III Trial
    • Schweighofer CD, Cymbalista F, Müller C, et al. Early versus deferred treatment with combined fludarabine, cyclophosphamide and rituximab (FCR) improves event-free survival in patients with high-risk Binet stage A chronic lymphocytic leukemia-First results of a randomized German-French Cooperative Phase III Trial. Blood 2013;122:abstract 524
    • (2013) Blood , vol.122
    • Schweighofer, C.D.1    Cymbalista, F.2    Müller, C.3
  • 32
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol 2005;23:4070-8
    • (2005) J Clin Oncol , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 33
    • 84886099684 scopus 로고    scopus 로고
    • Myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: Analysis of persistent and new-onset cytopenia
    • Strati P, Wierda W, Burger J, et al. Myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: analysis of persistent and new-onset cytopenia. Cancer 2013;119:3805-11
    • (2013) Cancer , vol.119 , pp. 3805-3811
    • Strati, P.1    Wierda, W.2    Burger, J.3
  • 34
    • 84856553821 scopus 로고    scopus 로고
    • Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Zhou Y, Tang G, Medeiros LJ, et al. Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Mod Pathol 2012;25:237-45
    • (2012) Mod Pathol , vol.25 , pp. 237-245
    • Zhou, Y.1    Tang, G.2    Medeiros, L.J.3
  • 35
    • 79954435811 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: Long-term follow-up of CALGB study 9712
    • Woyach JA, Ruppert AS, Heerema NA, et al. Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term follow-up of CALGB study 9712. J Clin Oncol 2011;29:1349-55
    • (2011) J Clin Oncol , vol.29 , pp. 1349-1355
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3
  • 36
    • 77950524161 scopus 로고    scopus 로고
    • Improving FCR immunochemotherapy in CLL
    • Robak T. Improving FCR immunochemotherapy in CLL. Blood 2010;115:437-8
    • (2010) Blood , vol.115 , pp. 437-438
    • Robak, T.1
  • 37
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 2007;109:405-11
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 38
    • 34447326480 scopus 로고    scopus 로고
    • Rituximab plus cladribine with or without cyclophosphamide in patients with relapsed or refractory chronic lymphocytic leukemia
    • Robak T, Smolewski P, Cebula B, et al. Rituximab plus cladribine with or without cyclophosphamide in patients with relapsed or refractory chronic lymphocytic leukemia. Eur J Haematol 2007;79:107-13
    • (2007) Eur J Haematol , vol.79 , pp. 107-113
    • Robak, T.1    Smolewski, P.2    Cebula, B.3
  • 39
    • 84898486579 scopus 로고    scopus 로고
    • Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients
    • Foa R, Del Giudice I, Cuneo A, et al. Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients. Am J Hematol 2014;89: 480-6
    • (2014) Am J Hematol , vol.89 , pp. 480-486
    • Foa, R.1    Del Giudice, I.2    Cuneo, A.3
  • 40
    • 84904818973 scopus 로고    scopus 로고
    • Rituximab plus chlorambucil as first-line treatment for chronic lymphocytic leukemia: Final analysis of an open-label phase II study
    • Hillmen P, Gribben JG, Follows GA, et al. Rituximab plus chlorambucil as first-line treatment for chronic lymphocytic leukemia: final analysis of an open-label phase II study. J Clin Oncol 2014;32:1236-41
    • (2014) J Clin Oncol , vol.32 , pp. 1236-1241
    • Hillmen, P.1    Gribben, J.G.2    Follows, G.A.3
  • 41
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter Phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K, Cramer P, Busch R, et al. Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter Phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2012;30:3209-16
    • (2012) J Clin Oncol , vol.30 , pp. 3209-3216
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 42
    • 84903201129 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a planned interim analysis of the CLL10 Trial, An international, randomized study of the German CLL Study Group (GCLLSG)
    • Eichhorst B, Fink AM, Busch R, et al. Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a planned interim analysis of the CLL10 Trial, An international, randomized study of the German CLL Study Group (GCLLSG). Blood 2013;122:Abstract 526
    • (2013) Blood , vol.122
    • Eichhorst, B.1    Fink, A.M.2    Busch, R.3
  • 43
    • 80053020928 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): A multicentre phase II trial of the German CLL study group (GCLLSG)
    • Fischer K, Stilgenbauer S, Schweighofer CD, et al. Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): a multicentre phase II trial of the German CLL study group (GCLLSG). J Clin Oncol 2011;29:3559-66
    • (2011) J Clin Oncol , vol.29 , pp. 3559-3566
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.D.3
  • 44
    • 0346258157 scopus 로고    scopus 로고
    • High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities
    • Thornton PD, Matutes E, Bosanquet AG, et al. High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities. Ann Hematol 2003;82: 759-65
    • (2003) Ann Hematol , vol.82 , pp. 759-765
    • Thornton, P.D.1    Matutes, E.2    Bosanquet, A.G.3
  • 45
    • 37149029392 scopus 로고    scopus 로고
    • Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features
    • Bowen DA, Call TG, Jenkins GD, et al. Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features. Leuk Lymphoma 2007;48:2412-17
    • (2007) Leuk Lymphoma , vol.48 , pp. 2412-2417
    • Bowen, D.A.1    Call, T.G.2    Jenkins, G.D.3
  • 46
    • 56249095457 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia
    • Castro JE, Sandoval-Sus JD, Bole J, et al. Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Leukemia 2008;22:2048-2053
    • (2008) Leukemia , vol.22 , pp. 2048-2053
    • Castro, J.E.1    Sandoval-Sus, J.D.2    Bole, J.3
  • 47
    • 84880891548 scopus 로고    scopus 로고
    • BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies
    • Robak T, Robak P. BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies. Int Rev Immunol 2013;32:358-76
    • (2013) Int Rev Immunol , vol.32 , pp. 358-376
    • Robak, T.1    Robak, P.2
  • 48
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32-42
    • (2013) N Engl J Med , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 49
    • 84896484537 scopus 로고    scopus 로고
    • Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): New, updated results of a phase ii trial in 40 patients
    • Burger JA, Keating MJ, Wierda WG, et al. Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): new, updated results of a phase ii trial in 40 patients. Blood 2013;122:abstract 675
    • (2013) Blood , vol.122
    • Burger, J.A.1    Keating, M.J.2    Wierda, W.G.3
  • 50
    • 84902316391 scopus 로고    scopus 로고
    • Ibrutinib in combination with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL/SLL: Final results of a phase 1b study
    • Brown JR, Barrientos JC, Barr PM, et al. Ibrutinib in combination with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL/SLL: final results of a phase 1b study. Blood 2013;122:abstract 525
    • (2013) Blood , vol.122
    • Brown, J.R.1    Barrientos, J.C.2    Barr, P.M.3
  • 51
    • 84901712964 scopus 로고    scopus 로고
    • Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110d, for relapsed/refractory chronic lymphocytic leukemia
    • Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110d, for relapsed/refractory chronic lymphocytic leukemia. Blood 2014;123:3390-7
    • (2014) Blood , vol.123 , pp. 3390-3397
    • Brown, J.R.1    Byrd, J.C.2    Coutre, S.E.3
  • 52
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997-1007
    • (2014) N Engl J Med , vol.370 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 53
    • 79952769640 scopus 로고    scopus 로고
    • Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia
    • Chen CI, Bergsagel PL, Paul H, et al. Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. J Clin Oncol 2011;29:1175-81
    • (2011) J Clin Oncol , vol.29 , pp. 1175-1181
    • Chen, C.I.1    Bergsagel, P.L.2    Paul, H.3
  • 54
    • 84905865264 scopus 로고    scopus 로고
    • Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: A multicenter clinical-translational study from the Chronic Lymphocytic Leukemia Research Consortium
    • James DF, Werner L, Brown JR, et al. Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: a multicenter clinical-translational study from the Chronic Lymphocytic Leukemia Research Consortium. J Clin Oncol 2014;32:2067-73
    • (2014) J Clin Oncol , vol.32 , pp. 2067-2073
    • James, D.F.1    Werner, L.2    Brown, J.R.3
  • 55
    • 44849134493 scopus 로고    scopus 로고
    • Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders
    • Robak T. Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders. Curr Opin Mol Ther 2008;10:294-309
    • (2008) Curr Opin Mol Ther , vol.10 , pp. 294-309
    • Robak, T.1
  • 56
    • 84885671483 scopus 로고    scopus 로고
    • Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
    • Herter S, Herting F, Mundigl O, et al. Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models. Mol Cancer Ther 2013;12:2031-42
    • (2013) Mol Cancer Ther , vol.12 , pp. 2031-2042
    • Herter, S.1    Herting, F.2    Mundigl, O.3
  • 57
    • 84899686547 scopus 로고    scopus 로고
    • Ofatumumab: A novel, fully human anti-CD20 monoclonal antibody for the treatment of chronic lymphocytic leukemia
    • Barth MJ, Czuczman MS. Ofatumumab: a novel, fully human anti-CD20 monoclonal antibody for the treatment of chronic lymphocytic leukemia. Future Oncol 2013;9:1829-39
    • (2013) Future Oncol , vol.9 , pp. 1829-1839
    • Barth, M.J.1    Czuczman, M.S.2
  • 58
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010;28:1749-55
    • (2010) J Clin Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 59
    • 84860738946 scopus 로고    scopus 로고
    • Oral high-dose glucocorticoids and ofatumumab in fludarabine-resistant chronic lymphocytic leukemia
    • Spaner DE. Oral high-dose glucocorticoids and ofatumumab in fludarabine-resistant chronic lymphocytic leukemia. Leukemia 2012;26:1144-5
    • (2012) Leukemia , vol.26 , pp. 1144-1145
    • Spaner, D.E.1
  • 60
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med 2014;371:213-23
    • (2014) N Engl J Med , vol.371 , pp. 213-223
    • Byrd, J.C.1    Brown, J.R.2    O'Brien, S.3
  • 61
    • 84867853067 scopus 로고    scopus 로고
    • A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases
    • Jaglowski SM, Jones JA, Flynn JM, et al. A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases. ASCO Meeting Abstracts. 2012. 30(Suppl 15): abstract 6508
    • (2012) ASCO Meeting Abstracts. , vol.30
    • Jaglowski, S.M.1    Jones, J.A.2    Flynn, J.M.3
  • 62
    • 84889095444 scopus 로고    scopus 로고
    • A phase III, randomized, controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with ofatumumab for previously treated chronic lymphocytic leukemia (CLL)
    • Flinn I, Kimby E, Cotter FE, et al. A phase III, randomized, controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with ofatumumab for previously treated chronic lymphocytic leukemia (CLL). J Clin Oncol 2013; 30(suppl):abstract TPS7131
    • (2013) J Clin Oncol , vol.30
    • Flinn, I.1    Kimby, E.2    Cotter, F.E.3
  • 63
    • 84896480883 scopus 로고    scopus 로고
    • Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (cll): Results of the phase III study Complement 1 (OMB110911)
    • Hillmen P, Robak T, Janssens A, et al. Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (cll): results of the phase III study Complement 1 (OMB110911). Blood 2013;122:abstract 528
    • (2013) Blood , vol.122
    • Hillmen, P.1    Robak, T.2    Janssens, A.3
  • 64
    • 67650657179 scopus 로고    scopus 로고
    • GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies
    • Robak T. GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr Opin Investig Drugs 2009;10:588-96
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 588-596
    • Robak, T.1
  • 65
    • 78651354250 scopus 로고    scopus 로고
    • Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells
    • Patz M, Isaeva P, Forcob N, et al. Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells. Br J Haematol 2011;152:295-306
    • (2011) Br J Haematol , vol.152 , pp. 295-306
    • Patz, M.1    Isaeva, P.2    Forcob, N.3
  • 66
    • 79953183947 scopus 로고    scopus 로고
    • Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab
    • Bologna L, Gotti E, Manganini M, et al. Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab. J Immunol 2011;186:3762-9
    • (2011) J Immunol , vol.186 , pp. 3762-3769
    • Bologna, L.1    Gotti, E.2    Manganini, M.3
  • 67
    • 79953183947 scopus 로고    scopus 로고
    • Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab
    • Bologna L, Gotti E, Manganini M, et al. Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab. J Immunol 2011;186:3762-9
    • (2011) J Immunol , vol.186 , pp. 3762-3769
    • Bologna, L.1    Gotti, E.2    Manganini, M.3
  • 68
    • 84861835530 scopus 로고    scopus 로고
    • Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients
    • Salles G, Morschhauser F, Lamy T, et al. Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients. Blood 2012;119: 5126-32
    • (2012) Blood , vol.119 , pp. 5126-5132
    • Salles, G.1    Morschhauser, F.2    Lamy, T.3
  • 69
    • 84877624236 scopus 로고    scopus 로고
    • Chemoimmunotherapy with GA101 plus chlorambucil in patients with chronic lymphocytic leukemia and comorbidity: Results of the CLL11 (BO21004) safety run-in
    • Goede V, Fischer K, Busch R, et al. Chemoimmunotherapy with GA101 plus chlorambucil in patients with chronic lymphocytic leukemia and comorbidity: results of the CLL11 (BO21004) safety run-in. Leukemia 2013;27:1172-4
    • (2013) Leukemia , vol.27 , pp. 1172-1174
    • Goede, V.1    Fischer, K.2    Busch, R.3
  • 70
    • 84894552888 scopus 로고    scopus 로고
    • Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
    • Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 2014;370: 1101-10
    • (2014) N Engl J Med , vol.370 , pp. 1101-1110
    • Goede, V.1    Fischer, K.2    Busch, R.3
  • 71
    • 84898414549 scopus 로고    scopus 로고
    • Head-to-head comparison of obinutuzumab (ga101) plus chlorambucil (clb) versus rituximab plus clb in patients with chronic lymphocytic leukemia (cll) and co-existing medical conditions (comorbidities): Final stage 2 results of the CLL11 trial
    • abstract 6
    • Goede V, Fischer K, Busch R, et al. Head-to-head comparison of obinutuzumab (ga101) plus chlorambucil (clb) versus rituximab plus clb in patients with chronic lymphocytic leukemia (cll) and co-existing medical conditions (comorbidities): final stage 2 results of the CLL11 trial. Blood 2013;122:abstract 6
    • (2013) Blood , vol.122
    • Goede, V.1    Fischer, K.2    Busch, R.3
  • 72
    • 84899667799 scopus 로고    scopus 로고
    • Obinutuzumab approved for CLL: Monoclonal antibody product is first FDA-approved breakthrough therapy
    • Traynor K. Obinutuzumab approved for CLL: monoclonal antibody product is first FDA-approved breakthrough therapy. Am J Health Syst Pharm 2013;70:2162
    • (2013) Am J Health Syst Pharm , vol.70 , pp. 2162
    • Traynor, K.1
  • 73
    • 84893054397 scopus 로고    scopus 로고
    • Obinutuzumab: First global approval
    • Cameron F, McCormack PL. Obinutuzumab: first global approval. Drugs 2014;74:147-54
    • (2014) Drugs , vol.74 , pp. 147-154
    • Cameron, F.1    McCormack, P.L.2
  • 74
    • 77951829072 scopus 로고    scopus 로고
    • Veltuzumab (humanized anti-CD20 monoclonal antibody): Characterization, current clinical results, and future prospects
    • Goldenberg DM, Morschhauser F, Wegener WA. Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects. Leuk Lymphoma 2010;51: 747-55
    • (2010) Leuk Lymphoma , vol.51 , pp. 747-755
    • Goldenberg, D.M.1    Morschhauser, F.2    Wegener, W.A.3
  • 75
    • 60849089338 scopus 로고    scopus 로고
    • Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
    • Goldenberg DM, Rossi EA, Stein R, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood 2009;113:1062-70
    • (2009) Blood , vol.113 , pp. 1062-1070
    • Goldenberg, D.M.1    Rossi, E.A.2    Stein, R.3
  • 76
    • 70249106098 scopus 로고    scopus 로고
    • Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results
    • Morschhauser F, Leonard JP, Fayad L, et al. Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol 2009;27:3346-53
    • (2009) J Clin Oncol , vol.27 , pp. 3346-3353
    • Morschhauser, F.1    Leonard, J.P.2    Fayad, L.3
  • 77
    • 79953883456 scopus 로고    scopus 로고
    • Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma
    • Negrea GO, Elstrom R, Allen SL, et al. Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma. Haematologica 2011;96:567-73
    • (2011) Haematologica , vol.96 , pp. 567-573
    • Negrea, G.O.1    Elstrom, R.2    Allen, S.L.3
  • 78
    • 84877944000 scopus 로고    scopus 로고
    • Monotherapy with subcutaneous (SC) injections of low doses of humanized anti-CD20 Veltuzumab is active in chronic lymphocytic leukemia (CLL)
    • Kalaycio M, Negrea OG, Elstrom R, et al. Monotherapy with subcutaneous (SC) injections of low doses of humanized anti-CD20 Veltuzumab is active in chronic lymphocytic leukemia (CLL). Blood (ASH Annual Meeting Abstracts) 2012;120: abstract 192
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Kalaycio, M.1    Negrea, O.G.2    Elstrom, R.3
  • 79
    • 84863259157 scopus 로고    scopus 로고
    • Results of a phase 1 study of AME-133v (LY2469298), an Fc-engineered humanized monoclonal anti-CD20 antibody, in FcgRIIIa-genotyped patients with previously treated follicular lymphoma
    • Forero-Torres A, de Vos S, Pohlman BL, et al. Results of a phase 1 study of AME-133v (LY2469298), an Fc-engineered humanized monoclonal anti-CD20 antibody, in FcgRIIIa-genotyped patients with previously treated follicular lymphoma. Clin Cancer Res 2012;18: 1395-403
    • (2012) Clin Cancer Res , vol.18 , pp. 1395-1403
    • Forero-Torres, A.1    De Vos, S.2    Pohlman, B.L.3
  • 80
    • 84899740940 scopus 로고    scopus 로고
    • Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia
    • Cheney CM, Stephens DM, Mo X, et al. Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia. MAbs 2014;6: 749-55
    • (2014) MAbs , vol.6 , pp. 749-755
    • Cheney, C.M.1    Stephens, D.M.2    Mo, X.3
  • 81
    • 79952087217 scopus 로고    scopus 로고
    • Phase i study of LY2469298, an Fc-engineered humanized anti-CD20 antibody, in patients with relapsed or refractory follicular lymphoma
    • Tobinai K, Ogura M, Kobayashi Y, et al. Phase I study of LY2469298, an Fc-engineered humanized anti-CD20 antibody, in patients with relapsed or refractory follicular lymphoma. Cancer Sci 2011;102:432-8
    • (2011) Cancer Sci , vol.102 , pp. 432-438
    • Tobinai, K.1    Ogura, M.2    Kobayashi, Y.3
  • 82
    • 84911413072 scopus 로고    scopus 로고
    • Phase 1/2 Study of ocaratuzumab, an Fc-engineered humanized anti-CD20 monoclonal antibody, in low affinity FcgRIIIa patients with previously treated follicular lymphoma
    • [Epub ahead of print]
    • Ganjoo KN, de Vos S, Pohlman BL, et al. Phase 1/2 Study of ocaratuzumab, an Fc-engineered humanized anti-CD20 monoclonal antibody, in low affinity FcgRIIIa patients with previously treated follicular lymphoma. Leuk Lymphoma 2014. [Epub ahead of print]
    • (2014) Leuk Lymphoma
    • Ganjoo, K.N.1    De Vos, S.2    Pohlman, B.L.3
  • 83
    • 11144357712 scopus 로고    scopus 로고
    • Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia
    • Keating M, Coutré S, Rai K, et al. Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia. Clin Lymphoma 2004;4:220-7
    • (2004) Clin Lymphoma , vol.4 , pp. 220-227
    • Keating, M.1    Coutré, S.2    Rai, K.3
  • 84
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997;15:1567-74
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 85
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood 2002;99:3554-61
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 86
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 2004;103:3278-81
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 87
    • 1542343949 scopus 로고    scopus 로고
    • Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia
    • Rawstron AC, Kennedy B, Moreton P, et al. Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia. Blood 2004;103: 2027-31
    • (2004) Blood , vol.103 , pp. 2027-2031
    • Rawstron, A.C.1    Kennedy, B.2    Moreton, P.3
  • 88
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A, Fassas AS, Anagnostopoulos A, et al. Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol 1996;93:151-3
    • (1996) Br J Haematol , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.S.2    Anagnostopoulos, A.3
  • 89
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 2007;25:5616-23
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 90
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S, Zenz T, Winkler D, et al. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2009;27:3994-4001
    • (2009) J Clin Oncol , vol.27 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3
  • 91
    • 84887204270 scopus 로고    scopus 로고
    • NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: Results from the CLL2H trial of the GCLLSG
    • Schnaiter A, Paschka P, Rossi M, et al. NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Blood 2013;122: 1266-70
    • (2013) Blood , vol.122 , pp. 1266-1270
    • Schnaiter, A.1    Paschka, P.2    Rossi, M.3
  • 92
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. J Clin Oncol 1997;15:1567-74
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 93
    • 84856272135 scopus 로고    scopus 로고
    • An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
    • Cortelezzi A, Gritti G, Laurenti L, et al. An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients. Br J Haematol 2012;156:481-9
    • (2012) Br J Haematol , vol.156 , pp. 481-489
    • Cortelezzi, A.1    Gritti, G.2    Laurenti, L.3
  • 94
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial
    • Elter T, Borchmann P, Schulz H, et al. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: results of a phase II trial. J Clin Oncol 2005;23: 7024-31
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3
  • 95
    • 82555169679 scopus 로고    scopus 로고
    • Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: A randomised phase 3 trial
    • Elter T, Gercheva-Kyuchukova L, Pylylpenko H, et al. Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial. Lancet Oncol 2011;12: 1204-13
    • (2011) Lancet Oncol , vol.12 , pp. 1204-1213
    • Elter, T.1    Gercheva-Kyuchukova, L.2    Pylylpenko, H.3
  • 96
    • 84871249105 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide in combination with alemtuzumab in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia
    • Elter T, James R, Busch R, et al. Fludarabine and cyclophosphamide in combination with alemtuzumab in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia. Leukemia 2012;26:2549-52
    • (2012) Leukemia , vol.26 , pp. 2549-2552
    • Elter, T.1    James, R.2    Busch, R.3
  • 97
    • 84907374559 scopus 로고    scopus 로고
    • Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients
    • 106740 [Epub ahead of print]
    • Montillo M, Tedeschi A, Gaidano G, et al. Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients. Haematologica 2014;106740. [Epub ahead of print]
    • (2014) Haematologica
    • Montillo, M.1    Tedeschi, A.2    Gaidano, G.3
  • 98
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemutuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemutuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma 2004;45:2269-73
    • (2004) Leuk Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.I.3
  • 99
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood 2003;101:3413-15
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 100
    • 84911395446 scopus 로고    scopus 로고
    • Phase II study of alemtuzumab-rituximab therapy in previously untreated patients with chronic lymphocytic leukemia: Short-and long-term outcomes
    • [Epub ahead of print]
    • Frankfurt O, Ma S, Gordon L, et al. Phase II study of alemtuzumab-rituximab therapy in previously untreated patients with chronic lymphocytic leukemia: short-and long-term outcomes. Leuk Lymph 2014. [Epub ahead of print]
    • (2014) Leuk Lymph
    • Frankfurt, O.1    Ma, S.2    Gordon, L.3
  • 101
    • 84902831336 scopus 로고    scopus 로고
    • Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells
    • Zent CS, Taylor RP, Lindorfer MA, et al. Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells. Am J Hematol 2014;89:757-65
    • (2014) Am J Hematol , vol.89 , pp. 757-765
    • Zent, C.S.1    Taylor, R.P.2    Lindorfer, M.A.3
  • 102
    • 0024511256 scopus 로고
    • The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen
    • Classon BJ, Williams AF, Willis AC, et al. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J Exp Med 1989;169:1497-502
    • (1989) J Exp Med , vol.169 , pp. 1497-1502
    • Classon, B.J.1    Williams, A.F.2    Willis, A.C.3
  • 103
    • 23744514951 scopus 로고    scopus 로고
    • Aberrant expression of tetraspanin molecules in B cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation
    • Barrena S, Almeida J, Yunta M, et al. Aberrant expression of tetraspanin molecules in B cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. Leukemia 2005;19: 1376-83
    • (2005) Leukemia , vol.19 , pp. 1376-1383
    • Barrena, S.1    Almeida, J.2    Yunta, M.3
  • 104
    • 84898748252 scopus 로고    scopus 로고
    • Anti-CD37 antibodies for chronic lymphocytic leukemia
    • Robak T, Robak P. Anti-CD37 antibodies for chronic lymphocytic leukemia. Exp Opin Biol Ther 2014;14:651-61
    • (2014) Exp Opin Biol Ther , vol.14 , pp. 651-661
    • Robak, T.1    Robak, P.2
  • 105
    • 80054115014 scopus 로고    scopus 로고
    • A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
    • Heider KH, Kiefer K, Zenz T. A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies. Blood 2011;118:4159-68
    • (2011) Blood , vol.118 , pp. 4159-4168
    • Heider, K.H.1    Kiefer, K.2    Zenz, T.3
  • 106
    • 84911446593 scopus 로고    scopus 로고
    • BI836826 Dose Escalation in Relapsed Chronic Lymphocytic Leukaemia (CLL)
    • BI836826 Dose Escalation in Relapsed Chronic Lymphocytic Leukaemia (CLL). Available from: www.clinicaltrials.gov/ct2/results?term=NCT01296 932&Search=Search
  • 107
    • 71249091846 scopus 로고    scopus 로고
    • TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies
    • Robak T, Robak P, Smolewski P. TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr Opin Investig Drugs 2009;10:1383-90
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1383-1390
    • Robak, T.1    Robak, P.2    Smolewski, P.3
  • 108
    • 34948858867 scopus 로고    scopus 로고
    • Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
    • Zhao X, Lapalombella R, Joshi T, et al. Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood 2007;110-2569-77
    • (2007) Blood , pp. 110-256977
    • Zhao, X.1    Lapalombella, R.2    Joshi, T.3
  • 109
    • 84896619061 scopus 로고    scopus 로고
    • A Phase 1 study evaluating the safety and tolerability of otlertuzumab (TRU-016), an anti-CD37 mono-specific ADAPTIRTM therapeutic protein in chronic lymphocytic leukemia
    • Byrd JC, Pagel JM, Awan FT, et al. A Phase 1 study evaluating the safety and tolerability of otlertuzumab (TRU-016), an anti-CD37 mono-specific ADAPTIRTM therapeutic protein in chronic lymphocytic leukemia. Blood 2014;123:1302-8
    • (2014) Blood , vol.123 , pp. 1302-1308
    • Byrd, J.C.1    Pagel, J.M.2    Awan, F.T.3
  • 110
    • 84898717593 scopus 로고    scopus 로고
    • Phase 2 study of otlertuzumab (TRU-016), an anti-CD37 ADAPTIRTM protein, in combination with bendamustine vs bendamustine alone in patients with relapsed chronic lymphocytic leukemia (CLL)
    • Robak T, Hellman A, Kloczko J, et al. Phase 2 study of otlertuzumab (TRU-016), an anti-CD37 ADAPTIRTM protein, in combination with bendamustine vs bendamustine alone in patients with relapsed chronic lymphocytic leukemia (CLL). Blood (ASH Annual Meeting Abstracts) 2013;122:abstract 2860
    • (2013) Blood (ASH Annual Meeting Abstracts) , vol.122
    • Robak, T.1    Hellman, A.2    Kloczko, J.3
  • 111
    • 84938689653 scopus 로고    scopus 로고
    • TM therapeutic protein, in combination with rituximab and bendamustine in relapsed indolent lymphoma patients
    • [Epub ahead of print]
    • TM therapeutic protein, in combination with rituximab and bendamustine in relapsed indolent lymphoma patients. Invest New Drugs 2014. [Epub ahead of print]
    • (2014) Invest New Drugs
    • Gopal, A.K.1    Tarantolo, S.R.2    Bellam, N.3
  • 112
    • 84899753936 scopus 로고    scopus 로고
    • Therapeutic targeting of CD19 in hematological malignancies: Past, present, future and beyond
    • Katz BZ, Herishanu Y. Therapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond. Leuk Lymphoma 2014;55: 999-1006
    • (2014) Leuk Lymphoma , vol.55 , pp. 999-1006
    • Katz, B.Z.1    Herishanu, Y.2
  • 113
    • 54249100952 scopus 로고    scopus 로고
    • Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia
    • Horton H M, Bernett M J, Pong E, et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res 2008;68:8049-57
    • (2008) Cancer Res , vol.68 , pp. 8049-8057
    • Horton, H.M.1    Bernett, M.J.2    Pong, E.3
  • 114
    • 77949499778 scopus 로고    scopus 로고
    • CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
    • Awan FT, Lapalombella R, Trotta R, et al. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood 2010;115:1204-13
    • (2010) Blood , vol.115 , pp. 1204-1213
    • Awan, F.T.1    Lapalombella, R.2    Trotta, R.3
  • 115
    • 65549147346 scopus 로고    scopus 로고
    • The impact of Fc engineering on an anti-CD19 antibody: Increased Fc gamma receptor affinity enhances B-cell clearing in nonhuman primates
    • Zalevsky J, Leung IW, Karki S, et al. The impact of Fc engineering on an anti-CD19 antibody: increased Fc gamma receptor affinity enhances B-cell clearing in nonhuman primates. Blood 2009;113: 3735-43
    • (2009) Blood , vol.113 , pp. 3735-3743
    • Zalevsky, J.1    Leung, I.W.2    Karki, S.3
  • 116
    • 84911396122 scopus 로고    scopus 로고
    • Final results of a phase i study of the Fc engineered CD19 antibody XmAb®5574 (MOR00208) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
    • Woyach JA, Avan F, Flinn IW, et al. Final results of a phase i study of the Fc engineered CD19 antibody XmAb®5574 (MOR00208) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Blood 2012;120:abstract 2894
    • (2012) Blood , vol.120
    • Woyach, J.A.1    Avan, F.2    Flinn, I.W.3
  • 117
    • 84911420915 scopus 로고    scopus 로고
    • Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL
    • Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL. Available from: www.clinicaltrials.gov/ct2/results?term=NCT02005289&Search=Search
  • 118
    • 27244432745 scopus 로고    scopus 로고
    • Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
    • Yazawa N, Hamaguchi Y, Poe JC, Tedder TF. Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proc Natl Acad Sci USA 2005;7:15178-83
    • (2005) Proc Natl Acad Sci USA , vol.7 , pp. 15178-15183
    • Yazawa, N.1    Hamaguchi, Y.2    Poe, J.C.3    Tedder, T.F.4
  • 119
    • 84899473907 scopus 로고    scopus 로고
    • A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies
    • Breton CS, Nahimana A, Aubry D, et al. A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies. J Hematol Oncol 2014;7:33. doi; 10.1186/1756-8722-7-33
    • (2014) J Hematol Oncol , vol.7 , pp. 33
    • Breton, C.S.1    Nahimana, A.2    Aubry, D.3
  • 120
    • 84878911052 scopus 로고    scopus 로고
    • Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodies
    • Matlawska-Wasowska K, Ward E, Stevens S, et al. Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodies. Leukemia 2013;27(6):1263-74
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1263-1274
    • Matlawska-Wasowska, K.1    Ward, E.2    Stevens, S.3
  • 121
    • 80054970846 scopus 로고    scopus 로고
    • A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo
    • Ward E, Mittereder N, Kuta E, et al. A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo. Br J Haematol 2011;155:426-37
    • (2011) Br J Haematol , vol.155 , pp. 426-437
    • Ward, E.1    Mittereder, N.2    Kuta, E.3
  • 122
    • 84911384732 scopus 로고    scopus 로고
    • Safety profile and clinical response to medi-551, a humanized monoclonal anti-cd19, in a phase 1/2 study in adults with relapsed or refractory advanced B-cell malignancies
    • Forero-Torres A, Mehdi Hamadani M, Michelle A, et al. Safety profile and clinical response to medi-551, a humanized monoclonal anti-cd19, in a phase 1/2 study in adults with relapsed or refractory advanced B-cell malignancies. Blood 2013;122:abstract 1810
    • (2013) Blood , vol.122
    • Forero-Torres, A.1    Mehdi Hamadani, M.2    Michelle, A.3
  • 123
    • 84911412093 scopus 로고    scopus 로고
    • A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
    • A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). Available from: www.clinicaltrials. gov/ct2/results?term=NCT01466153& Search=Search
  • 124
    • 0026642339 scopus 로고
    • CD23 antigen regulation and signaling in chronic lymphocytic leukemia
    • Fournier S, Delaspesse G, Rubio M, et al. CD23 antigen regulation and signaling in chronic lymphocytic leukemia. J Clin Invest 1992;89:1312-21
    • (1992) J Clin Invest , vol.89 , pp. 1312-1321
    • Fournier, S.1    Delaspesse, G.2    Rubio, M.3
  • 125
    • 34547691135 scopus 로고    scopus 로고
    • Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd JC, O'Brien S, Flinn IW, et al. Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res 2007;13:4448-55
    • (2007) Clin Cancer Res , vol.13 , pp. 4448-4455
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.W.3
  • 127
    • 84911405920 scopus 로고    scopus 로고
    • A randomized, open-label, multicenter, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide, and rituximab versus fludarabine, cyclophosphamide, and rituximab alone in subjects with relapsed chronic lymphocytic leukemia
    • [Epub ahead of print]
    • Awan FT, Hillmen P, Hellmann A, et al. A randomized, open-label, multicenter, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide, and rituximab versus fludarabine, cyclophosphamide, and rituximab alone in subjects with relapsed chronic lymphocytic leukemia. Br J Haematol 2014. [Epub ahead of print] doi; 10.1111/bjh. 13061
    • (2014) Br J Haematol
    • Awan, F.T.1    Hillmen, P.2    Hellmann, A.3
  • 128
    • 77958167235 scopus 로고    scopus 로고
    • Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
    • Horton HM, Bernett MJ, Peipp M, et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood 2010;116:3004-12
    • (2010) Blood , vol.116 , pp. 3004-3012
    • Horton, H.M.1    Bernett, M.J.2    Peipp, M.3
  • 129
    • 84861754264 scopus 로고    scopus 로고
    • Phase i study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia
    • Byrd JC, Kipps TJ, Flinn IW, et al. Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia. Leuk Lymphoma 2012;53: 2136-42
    • (2012) Leuk Lymphoma , vol.53 , pp. 2136-2142
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3
  • 130
    • 24944581157 scopus 로고    scopus 로고
    • Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
    • Law CL, Gordon KA, Collier J. Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40. Cancer Res 2005;65:8331-8
    • (2005) Cancer Res , vol.65 , pp. 8331-8338
    • Law, C.L.1    Gordon, K.A.2    Collier, J.3
  • 131
    • 70349334508 scopus 로고    scopus 로고
    • Phase i study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    • Advani R, Forero-Torres A, Furman RR, et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol 2009;27:4371-7
    • (2009) J Clin Oncol , vol.27 , pp. 4371-4377
    • Advani, R.1    Forero-Torres, A.2    Furman, R.R.3
  • 132
    • 76349120845 scopus 로고    scopus 로고
    • A phase i study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • Furman RR, Forero-Torres A, Shustov A, Drachman JG. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma 2010;51:228-35
    • (2010) Leuk Lymphoma , vol.51 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3    Drachman, J.G.4
  • 133
    • 77958167235 scopus 로고    scopus 로고
    • Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
    • Horton HM, Bernett MJ, Peipp M, et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood 2010;116:3004-12
    • (2010) Blood , vol.116 , pp. 3004-3012
    • Horton, H.M.1    Bernett, M.J.2    Peipp, M.3
  • 134
    • 84911401846 scopus 로고    scopus 로고
    • Phase I Study of Subcutaneous Ocaratuzumab in Patients With Previously Treated CD20+ B-Cell Malignancies
    • Phase I Study of Subcutaneous Ocaratuzumab in Patients With Previously Treated CD20+ B-Cell Malignancies. Available from: www.clinicaltrials.gov/ct2/results?term=NCT01858181&Search=Search
  • 135
    • 84911415157 scopus 로고    scopus 로고
    • Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLL
    • Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLL. Available from: www.clinicaltrials.gov/ct2/results?term=NCT00546793&Search=Search
  • 136
    • 84911399288 scopus 로고    scopus 로고
    • Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia
    • Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia. Available from: www.clinicaltrials.gov/ct2/results? term=NCT01188681&Search=Search
  • 137
    • 84911386598 scopus 로고    scopus 로고
    • A Safety Study in Patients With Chronic Lymphocytic Leukemia
    • A Safety Study in Patients With Chronic Lymphocytic Leukemia. Available from: www.clinicaltrials.gov/ct2/results? term=NCT00283101&Search=Search


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