Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: Studies in mice and FH children

Atherosclerosis

Volumn 229, Issue 1, 2013, Pages 79-85

  Tolani, Sonia ^a   Pagler, Tamara A ^a   Murphy, Andrew J ^a   Bochem, Andrea E ^a,b   Abramowicz, Sandra ^a   Welch, Carrie ^a   Nagareddy, Prabhakara R ^a   Holleran, Steve ^a   Hovingh, G K ^b   Kuivenhoven, Jan Albert ^c   Tall, Alan R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

ApoA1; Atherosclerosis; HDL C; Hematopoietic stem cells; Hypercholesterolemia

Indexed keywords

APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LDLR PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LRP1 PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN; SCARB1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EX VIVO STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MONOCYTE; MONOCYTOSIS; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

ADOLESCENT; ANIMALS; APOLIPOPROTEIN A-I; ATHEROSCLEROSIS; CELL PROLIFERATION; CHILD; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPOPROTEINS, LDL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; NEUTROPHILS;

EID: 84879414461     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.03.031     Document Type: Article

References (28)

1. Greenland P., Alpert J.S., Beller G.A., et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. JAm Coll Cardiol 2010, 56(25):e50-103.
2. Jacobs D.R., Mebane I.L., Bangdiwala S.I., Criqui M.H., Tyroler H.A. High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol 1990, 131(1):32-47.
3. Gordon D.J., Probstfield J.L., Garrison R.J., et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989, 79(1):8-15.
4. LaRosa J.C., Grundy S.M., Waters D.D., et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. NEngl J Med 2005, 352(14):1425-1435.
5. Aiello R.J., Brees D., Bourassa P.A., et al. Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Arterioscler Thromb Vasc Biol 2002, 22(4):630-637.
6. van Eck M., Bos I.S., Kaminski W.E., et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A 2002, 99(9):6298-6303.
7. Yvan-Charvet L., Ranalletta M., Wang N., et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. JClin Invest 2007, 117(12):3900-3908.
8. Khera A.V., Cuchel M., de la Llera-Moya M., et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. NEngl J Med 2011, 364(2):127-135.
9. Yvan-Charvet L., Pagler T., Gautier E.L., et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 2010, 328(5986):1689-1693.
10. Murphy A.J., Akhtari M., Tolani S., et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. JClin Invest 2011, 121(10):4138-4149.
11. Swirski F.K., Libby P., Aikawa E., et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. JClin Invest 2007, 117(1):195-205.
12. Tacke F., Alvarez D., Kaplan T.J., et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. JClin Invest 2007, 117(1):185-194.
13. -/- mice: link between cholesterol homeostasis and self-tolerance?. JLipid Res 2007, 48(1):52-65.
14. Zabalawi M., Bhat S., Loughlin T., et al. Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol. Am J Pathol 2003, 163(3):1201-1213.
15. Gillotte-Taylor K., Boullier A., Witztum J.L., Steinberg D., Quehenberger O. Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein. JLipid Res 2001, 42(9):1474-1482.
16. Lee C.D., Folsom A.R., Nieto F.J., Chambless L.E., Shahar E., Wolfe D.A. White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities study. Am J Epidemiol 2001, 154(8):758-764.
17. Junyent M., Cofan M., Nunez I., Gilabert R., Zambon D., Ros E. Influence of HDL cholesterol on preclinical carotid atherosclerosis in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2006, 26(5):1107-1113.
18. Hausmann D., Johnson J.A., Sudhir K., et al. Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins. JAm Coll Cardiol 1996, 27(7):1562-1570.
19. Li H., Reddick R.L., Maeda N. Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice. Arterioscler Thromb 1993, 13(12):1814-1821.
20. Plummer M.R., Hasty A.H. Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. JNutr Biochem 2008, 19(10):664-673.
21. Moore R.E., Kawashiri M.A., Kitajima K., et al. Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. Arterioscler Thromb Vasc Biol 2003, 23(10):1914-1920.
22. Voyiaziakis E., Goldberg I.J., Plump A.S., Rubin E.M., Breslow J.L., Huang L.S. ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice. JLipid Res 1998, 39(2):313-321.
23. Serfaty-Lacrosniere C., Civeira F., Lanzberg A., et al. Homozygous Tangier disease and cardiovascular disease. Atherosclerosis 1994, 107(1):85-98.
24. Hovingh G.K., de Groot E., van der Steeg W., et al. Inherited disorders ofHDL metabolism and atherosclerosis. Curr Opin Lipidol 2005, 16(2):139-145.
25. Schaefer E.J., Brousseau M.E., Diffenderfer M.R., et al. Cholesterol and apolipoprotein B metabolism in Tangier disease. Atherosclerosis 2001, 159(1):231-236.
26. Iqbal J., Hussain M.M. Evidence for multiple complementary pathways forefficient cholesterol absorption in mice. JLipid Res 2005, 46(7):1491-1501.
27. Ayyobi A.F., McGladdery S.H., Chan S., John Mancini G.B., Hill J.S., Frohlich J.J. Lecithin: cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease: 25 year follow-up. Atherosclerosis 2004, 177(2):361-366.
28. Tall A.R. Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. JIntern Med 2008, 263(3):256-273.