Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation

Journal of Biological Chemistry

Volumn 289, Issue 46, 2014, Pages 31837-31845

  Turner, Rebecca M ^a   Derryberry, Stephen L ^b   Kumar, Brijesh N ^a   Brittain, Thomas ^a   Zwiebel, Laurence J ^b   Newcomb, Richard D ^a,c   Christie, David L ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b VANDERBILT UNIVERSITY   (United States)

^c THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; ODORS;

CHANNEL ACTIVATION; CYSTEINE RESIDUES; DIFFERENTIAL EFFECT; DROSOPHILA MELANOGASTER; INTRACELLULAR LOOP; MUTATIONAL ANALYSIS; THIRD INTRACELLULAR LOOPS;

ACTIVATION ANALYSIS;

2 METHYLHEXANOATE; CALCIUM ION; CELL PROTEIN; CYSTEINE; HEXANOIC ACID; INTRACELLULAR LOOP 1; INTRACELLULAR LOOP 2; INTRACELLULAR LOOP 3; N (4 ETHYLPHENYL) 2 [[4 ETHYL 5 (3 PYRIDINYL) 4H 1,2,4 TRIAZOL 3 YL]THIO]ACETAMIDE; ODORANT CO RECEPTOR; ORGANOLEPTIC MODIFIER; RECEPTOR; SERINE; UNCLASSIFIED DRUG; CALCIUM; DROSOPHILA PROTEIN; EPITOPE; ION CHANNEL; N-(4-ETHYLPHENYL)-2-((4-ETHYL-5-(3-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETAMIDE; OLFACTORY RECEPTOR; OR22A PROTEIN, DROSOPHILA; OR83B PROTEIN, DROSOPHILA; PROTEIN BINDING; THIOGLYCOLIC ACID DERIVATIVE; TRIAZOLE DERIVATIVE;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL KINETICS; CELLULAR DISTRIBUTION; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG PROTEIN BINDING; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC CONSERVATION; GENETIC VARIABILITY; MOLECULAR MODEL; MUTATIONAL ANALYSIS; NONHUMAN; OLFACTORY RECEPTOR; ORCO GENE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP TECHNIQUE; WILD TYPE; ANIMAL; BINDING SITE; BIOTINYLATION; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; MUTATION; NUCLEOTIDE SEQUENCE; ODOR; PATCH CLAMP TECHNIQUE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

DROSOPHILA MELANOGASTER; HEXAPODA;

ALLOSTERIC SITE; ANIMALS; BIOTINYLATION; CALCIUM; CYSTEINE; DNA MUTATIONAL ANALYSIS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPITOPES; HEK293 CELLS; HUMANS; ION CHANNELS; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTATION; ODORS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ODORANT; THIOGLYCOLATES; TRIAZOLES;

EID: 84911191368     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.603993     Document Type: Article

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