Structure-activity relationship of a broad-spectrum insect odorant receptor agonist

ACS Chemical Biology

Volumn 7, Issue 10, 2012, Pages 1647-1652

  Taylor, Robert W ^a   Romaine, Ian M ^a   Liu, Chao ^a   Murthi, Poornima ^a   Jones, Patrick L ^a,b   Waterson, Alex G ^a   Sulikowski, Gary A ^a   Zwiebel, Laurence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG POTENCY; INSECT; LARVA; MOSQUITO; NONHUMAN; ODORANT RECEPTOR; OLFACTORY RECEPTOR; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; ANIMAL BEHAVIOR; ANOPHELES GAMBIAE; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; MOTOR ACTIVITY; SYNTHESIS;

ION CHANNEL; N-(4-ETHYLPHENYL)-2-((4-ETHYL-5-(3-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETAMIDE; OLFACTORY RECEPTOR; SMALL INTERFERING RNA; THIOGLYCOLIC ACID DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMALS; ANOPHELES GAMBIAE; BEHAVIOR, ANIMAL; HEK293 CELLS; HUMANS; ION CHANNELS; LARVA; MOTOR ACTIVITY; RECEPTORS, ODORANT; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGLYCOLATES; TRIAZOLES;

EID: 84867815414     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300331z     Document Type: Article

References (19)

1. Kaupp, U. B. (2010) Olfactory signalling in vertebrates and insects: differences and commonalities Nat. Rev. Neurosci. 11, 188-200
2. Smart, R., Kiely, A., Beale, M., Vargas, E., Carraher, C., Kralicek, A. V., Christie, D. L., Chen, C., Newcomb, R. D., and Warr, C. G. (2008) Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins Insect Biochem. Mol. Biol. 38, 770-780
3. Benton, R., Sachse, S., Michnick, S. W., and Vosshall, L. B. (2006) Atypical membrane topology and heteromeric function of drosophila odorant receptors in vivo PLoS Biol. 4, e20
4. Sato, K., Pellegrino, M., Nakagawa, T., Nakagawa, T., Vosshall, L. B., and Touhara, K. (2008) Insect olfactory receptors are heteromeric ligand-gated ion channels Nature 452, 1002-1006
5. Wicher, D., Schaäfer, R., Bauernfeind, R., Stensmyr, M. C., Heller, R., Heinemann, S. H., and Hansson, B. S. (2008) Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels Nature 452, 1007-1011
6. Nakagawa, T. (2005) Insect sex-pheromone signals mediated by specific combinations of olfactory receptors Science 307, 1638-1642
7. Larsson, M. C., Domingos, A. I., Jones, W. D., Chiappe, M. E., Amrein, H., and Vosshall, L. B. (2004) Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction Neuron 43, 703-714
8. Neuhaus, E. M., Gisselmann, G., Zhang, W., Dooley, R., Stoärtkuhl, K., and Hatt, H. (2004) Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster Nat. Neurosci. 8, 15-17
9. Jones, P. L., Pask, G. M., Rinker, D. C., and Zwiebel, L. J. (2011) Functional agonism of insect odorant receptor ion channels Proc. Natl. Acad. Sci. U.S.A. 108, 8821-8825
10. Elmore, T., Ignell, R., Carlson, J. R., and Smith, D. P. (2003) Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum J. Neurosci. 23, 9906-9912
11. Jones, W. D., Nguyen, T.-A. T., Kloss, B., Lee, K. J., and Vosshall, L. B. (2005) Functional conservation of an insect odorant receptor gene across 250 million years of evolution Curr. Biol. 15, R119-R121
12. Rinker, D. C., Jones, P. L., Pitts, R. J., Ruätzler, M., Camp, G., Sun, L., Xu, P., Dorset, D. C., Weaver, D., and Zwiebel, L. J. (2012) Novel high-throughput screens of Anopheles gambiae odorant receptors reveal candidate behaviour-modifying chemicals for mosquitoes Physiol. Entomol. 37, 33-41
13. Jones, P., Pask, G., Romaine, I., and Taylor, R. (2012) Allosteric Antagonism of Insect Odorant Receptor Ion Channels PLoS One 7 e30304
14. Bohbot, J. D., Jones, P. L., Wang, G., Pitts, R. J., Pask, G. M., and Zwiebel, L. J. (2011) Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait Chem. Senses 36, 149-160
15. Pask, G. M., Jones, P. L., Rutzler, M., Rinker, D. C., and Zwiebel, L. J. (2011) Heteromeric anopheline odorant receptors exhibit distinct channel properties PLoS One 6, e28774
16. Liu, C., Pitts, R. J., Bohbot, J. D., Jones, P. L., Wang, G., and Zwiebel, L. J. (2010) Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae PLoS Biol. 8, e1000467
17. Xia, Y., Wang, G., and Buscariollo, D. (2008) The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae Proc. Natl. Acad. Sci. U.S.A. 105, 6433-6438
18. Bohbot, J. D. and Dickens, J. C. (2012) Odorant receptor modulation: Ternary paradigm for mode of action of insect repellents Neuropharmacology 62, 2086-2095
19. Chen, S. and Luetje, C. W. (2012) Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit PLoS One 7, e36784