Inflammation-induced downregulation of butyrate uptake and oxidation is not caused by a reduced gene expression

Journal of Cellular Physiology

Volumn 230, Issue 2, 2015, Pages 418-426

  Boesmans, Leen ^a   Ramakers, Meine ^a   Arijs, Ingrid ^a,b   Windey, Karen ^a   Vanhove, Wiebe ^a   Schuit, Frans ^b   Rutgeerts, Paul ^a   Verbeke, Kristin ^a   De Preter, Vicky ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BUTYRIC ACID DERIVATIVE; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

DOWN REGULATION; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; HT 29 CELL LINE; HUMAN; INFLAMMATION; METABOLISM; OXIDATION REDUCTION REACTION;

ANTI-INFLAMMATORY AGENTS; BUTYRATES; CYTOKINES; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION; HT29 CELLS; HUMANS; INFLAMMATION; OXIDATION-REDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84911163615     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24725     Document Type: Article

References (29)

1. Arijs I, De Hertogh G, Lemaire K, Quintens R, Van Lommel L, Van Steen K, Leemans P, Cleynen I, Van Assche G, Vermeire S, Geboes K, Schuit F, Rutgeerts P. 2009. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One 4:e7984.
2. Arijs I, De Hertogh G, Machiels K, Van Steen K, Lemaire K, Schraenen A, Van Lommel L, Quintens R, Van Assche G, Vermeire S, Schuit F, Rutgeerts P. 2011. Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment. Am J Gastroenterol 106:748-761.
3. Banks C, Bateman A, Payne R, Johnson P, Sheron N. 2003. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol 199:28-35.
4. De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, Schuit F, Rutgeerts P, Verbeke K. 2012. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis 18:1127-1136.
5. De Preter V, Bulteel V, Suenaert P, Geboes KP, De Hertogh G, Luypaerts A, Geboes K, Verbeke K, Rutgeerts P. 2009. Pouchitis, similar to active ulcerative colitis, is associated with impaired butyrate oxidation by intestinal mucosa. Inflamm Bowel Dis 15:335-340.
6. De Preter V, Rutgeerts P, Schuit F, Verbeke K, Arijs I. 2013. Impaired expression of genes involved in the butyrate oxidation pathway in Crohn's disease patients. Inflamm Bowel Dis 19:E43-E44.
7. Den Hond E, Hiele M, Evenepoel P, Peeters M, Ghoos Y, Rutgeerts P. 1998. In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis. Gastroenterology 115:584-590.
8. Duffy MM, Regan MC, Ravichandran P, O'Keane C, Harrington MG, Fitzpatrick JM, O'Connell PR. 1998. Mucosal metabolism in ulcerative colitis and Crohn's disease. Dis Colon Rectum 41:1399-1405.
9. Eckmann L, Jung HC, Schurer-Maly C, Panja A, Morzycka-Wroblewska E, Kagnoff MF. 1993. Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8. Gastroenterology 105:1689-1697.
10. Garside P. 1999. Cytokines in experimental colitis. Clin Exp Immunol 118:337-339.
11. Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ, Ramaswamy K. 2000. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am J Physiol Gastrointest Liver Physiol 279:G775-G780.
12. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. 2008. Review article: The role of butyrate on colonic function. Aliment Pharmacol Ther 27:104-119.
13. Izutani R, Loh EY, Reinecker HC, Ohno Y, Fusunyan RD, Lichtenstein GR, Rombeau JL, Macdermott RP. 1995. Increased expression of interleukin-8 mRNA in ulcerative colitis and Crohn's disease mucosa and epithelial cells. Inflamm Bowel Dis 1:37-47.
14. Khurana S, George SP. 2008. Regulation of cell structure and function by actin-binding proteins: Villin's perspective. FEBS Lett 582:2128-2139.
15. Kolios G, Robertson DA, Jordan NJ, Minty A, Caput D, Ferrara P, Westwick J. 1996. Interleukin-8 production by the human colon epithelial cell line HT-29: Modulation by interleukin-13. Br J Pharmacol 119:351-359.
16. Nancey S, Moussata D, Graber I, Claudel S, Saurin DC, Flourie B. 2005. Tumor necrosis factor alpha reduces butyrate oxidation in vitro in human colonic mucosa: A link from inflammatory process to mucosal damage. Inflamm Bowel Dis 11:559-566.
17. Pedersen G, Saermark T, Horn T, Giese B, Bendtzen K, Brynskov J. 2000. Cytokine-induced impairment of short-chain fatty acid oxidation and viability in human colonic epithelial cells. Cytokine 12:1400-1404.
18. Perrier C, Rutgeerts P. 2011. Cytokine blockade in inflammatory bowel diseases. Immunotherapy 3:1341-1352.
19. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45.
20. Reimund JM, Wittersheim C, Dumont S, Muller CD, Kenney JS, Baumann R, Poindron P, Duclos B. 1996. Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease. Gut 39:684-689.
21. Roediger WEW. 1980a. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21:793-798.
22. Roediger WEW. 1980b. The colonic epithelium in ulcerative colitis: An energy-deficiency disease. Lancet 2:712-715.
23. Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. 2008. Role of cytokines in inflammatory bowel disease. World J Gastroenterol 14:4280-4288.
24. Santhanam S, Venkatraman A, Ramakrishna BS. 2007. Impairment of mitochondrial acetoacetyl CoA thiolase activity in the colonic mucosa of patients with ulcerative colitis. Gut 56:1543-1549.
25. Schiller JH, Bittner G, Storer B, Willson JK. 1987. Synergistic antitumor effects of tumor necrosis factor and gamma-interferon on human colon carcinoma cell lines. Cancer Res 47:2809-2813.
26. Strober W, Fuss IJ. 2011. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1756-1767.
27. Thibault R, De Coppet P, Daly K, Bourreille A, Cuff M, Bonnet C, Mosnier JF, Galmiche JP, Shirazi-Beechey S, Segain JP. 2007. Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation. Gastroenterology 133:1916-1927.
28. Thibault R, Blachier F, Darcy-Vrillon B, De Coppet P, Bourreille A, Segain JP. 2010. Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: A transport deficiency. Inflamm Bowel Dis 16:684-695.
29. Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S. 2011. Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. Inflamm Bowel Dis 17:2076-2086.