Runx1 activities in superficial zone chondrocytes, osteoarthritic chondrocyte clones and response to mechanical loading

Journal of Cellular Physiology

Volumn 230, Issue 2, 2015, Pages 440-448

  Leblanc, Kimberly T ^a   Walcott, Marie E ^a   Gaur, Tripti ^a   O'Connell, Shannon L ^a   Basil, Kirti ^a   Tadiri, Christina P ^a   Mason Savas, April ^a   Silva, Jason A ^a   van Wijnen, Andre J ^a,c   Stein, Janet L ^a,b   Stein, Gary S ^a,b   Ayers, David C ^a   Lian, Jane B ^a,b   Fanning, Paul J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR RUNX1;

AGED; ANIMAL; ARTICULAR CARTILAGE; BOVINE; CARTILAGE CELL; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; FEMALE; HUMAN; KNEE OSTEOARTHRITIS; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MIDDLE AGED; OSTEOARTHRITIS, KNEE;

EID: 84911072526     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24727     Document Type: Article

References (50)

1. Chuang LS, Ito K, Ito Y. 2013. RUNX family: Regulation and diversification of roles through interacting proteins. Int J Cancer 132:1260-1271.
2. Dowthwaite GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJ, Haughton L, Bayram Z, Boyer S, Thomson B, et al. 2004. The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117:889-897.
3. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, Ballock RT, Lefebvre V. 2012. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell 22:597-609.
4. Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, Trippel SB. 2003. Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem 278:50940-50948.
5. Fitzgerald JB, Jin M, Chai DH, Siparsky P, Fanning P, Grodzinsky AJ. 2008. Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. J Biol Chem 283:6735-6743.
6. Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermudez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM, et al. 2009. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 60:840-847.
7. Glasson SS, Blanchet TJ, Morris EA. 2007. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 5:1061-1069.
8. Grogan SP, Miyaki S, Asahara H, D'Lima DD, Lotz MK. 2009. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 11:R85.
9. Growney JD, Shigematsu H, Li Z, Lee BH, Adelsperger J, Rowan R, Curley DP, Kutok JL, Akashi K, Williams IR, et al. 2005. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 106:494-504.
10. Hidaka C, Cheng C, Alexandre D, Bhargava M, Torzilli PA. 2006. Maturational differences in superficial and deep zone articular chondrocytes. Cell Tissue Res 323:127-135.
11. Hiraoka K, Grogan S, Olee T, Lotz M. 2006. Mesenchymal progenitor cells in adult human articular cartilage. Biorheology 43:447-454.
12. Jay GD, Fleming BC, Watkins BA, McHugh KA, Anderson SC, Zhang LX, Teeple E, Waller KA, Elsaid KA. 2010. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 62:2382-2391.
13. Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, et al. 2012. A stem cell-based approach to cartilage repair. Science 336:717-721.
14. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S. 2006. Karsenty G et al: Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 54:2462-2470.
15. Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, et al. 2010. Runx1 and Runx2 cooperate during sternal morphogenesis. Development 137:1159-1167.
16. Knobloch TJ, Madhavan S, Nam J, Agarwal S, Jr., Agarwal S. 2008. Regulation of chondrocytic gene expression by biomechanical signals. Crit Rev Eukaryot Gene Expr 18:139-150.
17. Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N. 2009. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 4:324-335.
18. Komori T. 2005. Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem 95:445-453.
19. Lengner CJ, Hassan MQ, Serra RW, Lepper C, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2005. Nkx3. 2-mediated repression of Runx2 promotes chondrogenic differentiation. J Biol Chem 280:15872-15879.
20. Lengner CJ, Lepper C, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 2004. Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation. J Cell Physiol 200:327-333.
21. Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, et al. 2001. Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev 109:413-417.
22. Li NG, Shi ZH, Tang YP, Wang ZJ, Song SL, Qian LH, Qian DW, Duan JA. 2011. New hope for the treatment of osteoarthritis through selective inhibition of MMP-13. Curr Med Chem 18:977-1001.
23. Liakhovitskaia A, Lana-Elola E, Stamateris E, Rice DP, van't Hof, Medvinsky RJ. 2010. The essential requirement for Runx1 in the development of the sternum. Dev Biol 340:539-546.
24. Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, Van Wijnen AJ, Stein JL, Speck N, et al. 2003. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. J Cell Physiol 196:301-311.
25. Lotz MK, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D'Lima D. 2010. Cartilage cell clusters. Arthritis Rheum 62:2206-2218.
26. Markova EN, Kantidze OL, Razin SV. 2011. Transcriptional regulation and spatial organisation of the human AML1/RUNX1 gene. J Cell Biochem 112:1997-2005.
27. Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 2005. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol 25:8581-8591.
28. Pretzel D, Linss S, Rochler S, Endres M, Kaps C, Alsalameh S, Kinne RW. 2011. Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther 13:R64.
29. Ryan JA, Eisner EA, DuRaine G, You Z, Reddi AH. 2009. Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: implications for tissue engineering and regenerative medicine. J Tissue Eng Regen Med 3:107-116.
30. Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, et al. 2008. The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Arthritis Rheum 58:2764-2775.
31. Scheitz CJ, Tumbar T. 2013. New insights into the role of Runx1 in epithelial stem cell biology and pathology. J Cell Biochem 114:985-993.
32. Schmitz N, Laverty S, Kraus VB, Aigner T. 2010. Basic methods in histopathology of joint tissues. Osteoarthritis Cartilage 18:S113-S116.
33. Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE. 1994. A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. Arch Biochem Biophys 311:144-152.
34. Selvamurugan N, Jefcoat SC, Kwok S, Kowalewski R, Tamasi JA, Partridge NC. 2006. Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo. J Cell Biochem 99:545-557.
35. Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, Uematsu S, Yoshida Y, Kamioka H, Takano-Yamamoto T, et al. 2011. Sox9 expression during fracture repair. Cells Tissues Organs 194:38-48.
36. Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, et al. 2005. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol 203:133-143.
37. Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. 2007. Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res 22:1260-1270.
38. Soung do Y, Talebian L, Matheny CJ, Guzzo R, Speck ME, Lieberman JR, Speck NA, Drissi H. 2012. Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. J Bone Miner Res 27:1585-1597.
39. Stricker S, Fundele R, Vortkamp A, Mundlos S. 2002. Role of Runx genes in chondrocyte differentiation. Dev Biol 245:95-108.
40. Swiers G, de Bruijn M, Speck NA. 2010. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol 54:1151-1163.
41. Takarada T, Hinoi E, Nakazato R, Ochi H, Xu C, Tsuchikane A, Takeda S, Karsenty G, Abe T, Kiyonari H, et al. 2013. An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res 28:2064-2069.
42. Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. 2005. Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J Bone Miner Res 20:1624-1636.
43. Werner FW, Ayers DC, Maletsky LP, Rullkoetter PJ. 2005. The effect of valgus/varus malalignment on load distribution in total knee replacements. J Biomech 38:349-355.
44. Whitfield TA. 2012. Putative Runx binding sites in human PRG4 gene. http://zlabumassmededu/?whitfiet/FIMO/PRG4/fimohtml.
45. Whitfield TA. 2012. Putative Runx binding sites in human ACAN gene. http://zlabumassmededu/?whitfiet/FIMO/ACAN/finohtml.
46. Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC. 2013. Functional role of Runx3 in the regulation of aggrecan expression during cartilage development. J Cell Physiol 228:2232-2242.
47. Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J, Biswas D, Roeder RG, Allis CD, Melnick A, et al. 2013. RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep 3:116-127.
48. Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, et al. 2013. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72:748-753.
49. Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, et al. 2004. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18:952-963.
50. Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2011. Bookmarking the genome: Maintenance of epigenetic information. J Biol Chem 286:18355-18361.