Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: Implications for tissue engineering and regenerative medicine

Journal of Tissue Engineering and Regenerative Medicine

Volumn 3, Issue 2, 2009, Pages 107-116

  Ryan, James A ^a,b   Eisner, Eric A ^a,c   DuRaine, Grayson ^a   You, Zongbing ^a,d   Reddi, A Hari ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Articular cartilage; Chondrocyte proliferation; Extracellular signal regulated kinase 1 2 (ERK 1 2) pathway; Mechanical compression; Proteoglycan synthesis; Regenerative medicine; Tissue engineering

Indexed keywords

BODY FLUIDS; ENZYME ACTIVITY; FLUORIDATION; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; STRAIN RATE; TISSUE REGENERATION;

ARTICULAR CARTILAGES; CARTILAGE EXPLANTS; CHONDROCYTE PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2 PATHWAY; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; MECHANICAL COMPRESSION; PATHWAY INHIBITORS; PROTEOGLYCAN SYNTHESIS; REGENERATIVE MEDICINE; TISSUES ENGINEERINGS;

CARTILAGE;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEOGLYCAN; CYCLINE; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; ARTICULAR CARTILAGE; CALF (BOVINE); CARTILAGE CELL; CELL PROLIFERATION; COMPRESSION; CONTROLLED STUDY; ENZYME ACTIVATION; EXPLANT; IMMUNOHISTOCHEMISTRY; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; ANIMAL; BIOSYNTHESIS; CATTLE; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CATTLE; CELL PROLIFERATION; CHONDROCYTES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASE INHIBITORS; PROTEOGLYCANS; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; TISSUE ENGINEERING;

EID: 66949171091     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.146     Document Type: Article

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