Alcohol, Phospholipase A2-associated Neuroinflammation, and ω3 Docosahexaenoic Acid Protection

Molecular Neurobiology

Volumn 50, Issue 1, 2014, Pages 239-245

  Collins, Michael A ^a   Tajuddin, Nuzhath ^a   Moon, Kwan Hoon ^a   Kim, Hee Yong ^b   Nixon, Kimberly ^c   Neafsey, Edward J ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

DHA; Ethanol; Neurodegeneration; Neuroprotection; Organotypic; PARP 1; PLA2

Indexed keywords

ALCOHOL; AQUAPORIN 4; ARACHIDONIC ACID; CERVONIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHOLIPASE A2; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; DOCOSAHEXAENOIC ACID;

BRAIN EDEMA; BRAIN SLICE; IN VITRO STUDY; IN VIVO STUDY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; REVIEW; SUPPLEMENTATION; ANIMAL; ASTROCYTE; CHEMICALLY INDUCED; DRUG EFFECTS; ENCEPHALITIS; HIPPOCAMPUS; MALE; METABOLISM; RAT;

ANIMALS; AQUAPORIN 4; ASTROCYTES; DOCOSAHEXAENOIC ACIDS; ENCEPHALITIS; ETHANOL; HIPPOCAMPUS; MALE; OXIDATIVE STRESS; PHOSPHOLIPASES A2; RATS;

EID: 84911003244     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8690-0     Document Type: Review

References (51)

1. Collins MA, Neafsey EJ (2012) Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity. Front Biosci 4:1358–1367
2. Sun GY, Rudeen PK, Wood WG, Wei YH, Sun AY (1989) Molecular mechanisms of alcohol: neurobiology and metabolism. Humana, Clifton, p 397
3. Sun AY, Ingelman-Sundberg M, Neve E, Matsumoto H, Nishitani Y, Minowa Y, Fukui Y, Bailey SM, Patel VB, Cunningham CC, Zima T, Fialova L, Mikulikova L, Popov P, Malbohan I, Janebova M, Nespor K, Sun GY (2001) Ethanol and oxidative stress. Alcohol Clin Exp Res 25:237S–243S
4. Corso TD, Mostafa HM, Collins MA, Neafsey EJ (1998) Brain neuronal degeneration caused by episodic alcohol intoxication in rats: effects of nimodipine, 6,7-dinitro-quinoxaline-2,3-dione, and MK-801. Alcohol Clin Exp Res 22:217–224
5. Collins MA, Zou JY, Neafsey EJ (1998) Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism. Faseb J 12:221–230
6. Hamelink C, Hampson A, Wink DA, Eiden LE, Eskay RL (2005) Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity. J Pharmacol Exp Ther 314:780–788
7. Majchrowicz E (1975) Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 43:245–254
8. Snyder H, Williams D, Zink B, Reilly K (1992) Accuracy of blood ethanol determination using serum osmolality. J Emerg Med 10:129–133
9. Adachi J, Mizoi Y, Fukunaga T, Ogawa Y, Ueno Y, Imamichi H (1991) Degrees of alcohol intoxication in 117 hospitalized cases. J Stud Alcohol 52:448–453
10. David KK, Andrabi SA, Dawson TM, Dawson VL (2009) Parthanatos, a messenger of death. Front Biosci 14:1116–1128
11. Aschner M, Allen JW, Mutkus LA, Cao C (2001) Ethanol-induced swelling in neonatal rat primary astrocyte cultures. Brain Res 900:219–226
12. Sripathirathan K, Brown J, Neafsey EJ, Collins MA (2009) Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. J Neurotrauma 26:261–273
13. Huber VJ, Tsujita M, Yamazaki M, Sakimura K, Nakada T (2007) Identification of arylsulfonamides as Aquaporin 4 inhibitors. Bioorg Med Chem Lett 17:1270–1273
14. Tanimura Y, Hiroaki Y, Fujiyoshi Y (2009) Acetazolamide reversibly inhibits water conduction by aquaporin-4. J Struct Biol 166:16–21
15. Fukuda AM, Badaut J (2012) Aquaporin 4: a player in cerebral edema and neuroinflammation. J Neuroinflammation 9:279
16. Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H (2012) Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure. Am J Pathol 180:17–23
17. Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS (2011) Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J 25:1556–1566
18. Sun GY, Shelat PB, Jensen MB, He Y, Sun AY, Simonyi A (2010) Phospholipases A2 and inflammatory responses in the central nervous system. NeuroMolecular Med 12:133–148
19. Adibhatla RM, Hatcher JF (2008) Phospholipase A (2), reactive oxygen species, and lipid peroxidation in CNS pathologies. BMB Rep 41:560–567
20. Yagami T, Yamamoto Y, Koma H (2013) The role of secretory phospholipase A2 in the central nervous system and neurological diseases. Mol Neurobiol 1–14
21. Moses GS, Jensen MD, Lue LF, Walker DG, Sun AY, Simonyi A, Sun GY (2006) Secretory PLA2-IIA: a new inflammatory factor for Alzheimer’s disease. J Neuroinflammation 3
22. Green JT, Orr SK, Bazinet RP (2008) The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids. J Lipid Res 49:939–944
23. Allyson J, Bi X, Baudry M, Massicotte G (2012) Maintenance of synaptic stability requires calcium-independent phospholipase A 2 activity. Neural Plast 2012
24. Tajuddin N, Przybycien-Szymanska MM, Mitchell RM, Pak TR, Neafsey EJ, Collins MA (2012) Adult rats subjected to repetitive binge-pattern ethanol exposure show evidence of neuroinflammation involving elevated aquaporin-4, PLA2 and PARP-1. Alcohol Clin Exp Res 36:35A
25. Tajuddin N, Przybycien-Szymanska MM, Pak TR, Neafsey EJ, Collins MA (2013) Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation. Alcohol 47:39–45
26. Chiu LY, Ho FM, Shiah SG, Chang Y, Lin WW (2011) Oxidative stress initiates DNA damager MNNG-induced poly (ADP-ribose) polymerase-1-dependent parthanatos cell death. Biochem Pharmacol 81:459–470
27. Collins MA, Corso TD, Neafsey EJ (1996) Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic “binge” intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin Exp Res 20:284–292
28. Brown J 3rd, Achille N, Neafsey EJ, Collins MA (2009) Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). Neurochem Res 34:260–267
29. Collins MA, Moon KH, Tajuddin N, Neafsey EJ, Kim HY (2013) Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. Neurotoxicity Res 23:105–110
30. Bazan NG, Molina MF, Gordon WC (2011) Docosahexaenoic Acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases. Annu Rev Nutr 31:321–351
31. Wang J, Du H, Jiang L, Ma X, de Graaf RA, Behar KL, Mason GF (2013) Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proc Natl Acad Sci 110:14444–14449
32. Heit C, Dong H, Chen Y, Thompson DC, Deitrich RA, Vasiliou VK (2013) The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. Subcell Biochem 67:235–247
33. Alikunju S, Abdul Muneer PM, Zhang Y, Szlachetka AM, Haorah J (2011) The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components. Brain Behav Immun 25:S129–S136
34. Knapp DJ, Crews FT (1999) Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal. Alcohol Clin Exp Res 23:633–643
35. Crews F, Nixon K, Kim D, Joseph J, Shukitt-Hale B, Qin L, Zou J (2006) BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol Clin Exp Res 30:1938–1949
36. Cippitelli A, Damadzic R, Frankola K, Goldstein A, Thorsell A, Singley E, Eskay RL, Heilig M (2010) Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation. Biol Psychiatry 67:823–830
37. Ryu KY, Cho GS, Piao HZ, Kim WK (2012) Role of TGF-beta in survival of phagocytizing microglia: autocrine suppression of TNF-alpha production and oxidative stress. Exp Neurobiol 21:151–157
38. Ashley DM, Sampson JH, Archer GE, Hale LP, Bigner DD (1998) Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. J Neuroimmunol 86:46–52
39. Pushpakiran G, Mahalakshmi K, Anuradha CV (2004) Taurine restores ethanol-induced depletion of antioxidants and attenuates oxidative stress in rat tissues. Amino Acids 27:91–96
40. Baydas G, Tuzcu M (2005) Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats. Exp Neurol 194:175–181
41. Amanvermez R, Agara E (2006) Does ascorbate/L-Cys/L-Met mixture protect different parts of the rat brain against chronic alcohol toxicity? Adv Ther 23:705–718
42. Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, Gharbi N, Kamoun A, El-Fazaa S (2006) Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol Alcohol 41:236–239
43. Jayaraman T, Kannappan S, Ravichandran MK, Anuradha CV (2008) Impact of Essentiale L on ethanol-induced changes in rat brain and erythrocytes. Singap Med J 49:320–327
44. Tiwari V, Kuhad A, Chopra K (2009) Suppression of neuro-inflammatory signaling cascade by tocotrienol can prevent chronic alcohol-induced cognitive dysfunction in rats. Behav Brain Res 203:296–303
45. Tiwari V, Chopra K (2013) Resveratrol abrogates alcohol-induced cognitive deficits by attenuating oxidative-nitrosative stress and inflammatory cascade in the adult rat brain. Neurochem Int 62:861–869
46. Tiwari V, Chopra K (2013) Protective effect of curcumin against chronic alcohol-induced cognitive deficits and neuroinflammation in the adult rat brain. Neuroscience 244:147–158
47. Akbar M, Calderon F, Wen Z, Kim HY (2005) Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A 102:10858–10863
48. Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ, Bazan NG (2011) Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPAR-mediated mechanisms in Alzheimer’s disease models. PLoS ONE 6:e15816, Electronic Resource
49. Kim HY, Spector AA (2013) Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. Prostaglandins Leukot Essent Fat Acids 88:121–125
50. Song BJ, Moon KH, Olsson NU, Salem N Jr (2008) Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids. J Hepatol 49:262–273
51. Przybycien-Szymanska MM, Mott NN, Paul CR, Gillespie RA, Pak TR (2011) Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity. PLoS ONE 6:e18350