Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer

Molecular Cancer Research

Volumn 12, Issue 11, 2014, Pages 1677-1688

  Jiao, Jing ^a   Ishikawa, Tomo O ^a,e   Dumlao, Darren S ^b,c   Norris, Paul C ^b,c   Magyar, Clara E ^a   Mikulec, Carol ^d   Catapang, Art ^a   Dennis, Edward A ^b,c   Fischer, Susan M ^d   Herschman, Harvey R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c San Diego   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e TransGenic Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; ICOSANOID; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; 7,12 DIMETHYLBENZ[A]ANTHRACENE; PHORBOL 13 ACETATE 12 MYRISTATE; PTGS2 PROTEIN, MOUSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER INCIDENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS CELL; EPIDERMIS HYPERPLASIA; GENE DELETION; GENE TARGETING; KERATINOCYTE; LIPIDOMICS; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SKIN CARCINOGENESIS; SKIN EPITHELIUM; SKIN PAPILLOMA; SKIN TUMOR; TUMOR GROWTH; TUMOR MICROENVIRONMENT; ANIMAL; CHEMICALLY INDUCED; ENZYMOLOGY; EPIDERMIS; EPITHELIUM CELL; HYPERPLASIA; LIPID METABOLISM; METABOLISM; PAPILLOMA; PATHOLOGY; SKIN; VASCULARIZATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLOOXYGENASE 2; EICOSANOIDS; EPIDERMIS; EPITHELIAL CELLS; GENE DELETION; GENE TARGETING; HYPERPLASIA; KERATINOCYTES; LIPID METABOLISM; MACROPHAGES; MICE; MYELOID CELLS; PAPILLOMA; SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 84910647084     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0397-T     Document Type: Article

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