An empirical comparison of the therapeutic benefits of physical exercise and cognitive training on the executive functions of older adults: A meta-analysis of controlled trials

Neuropsychology

Volumn 28, Issue 6, 2014, Pages 829-845

  Karr, Justin E ^a   Areshenkoff, Corson N ^a   Rast, Philippe ^a   Garcia Barrera, Mauricio A ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Aging; Cognitive training; Executive function; Meta analysis; Physical exercise

Indexed keywords

AGING; ARTICLE; COGNITION; COGNITIVE TRAINING; CONTROLLED CLINICAL TRIAL (TOPIC); EFFECT SIZE; EXECUTIVE FUNCTION; EXERCISE; HUMAN; META ANALYSIS; PRIORITY JOURNAL; PROBLEM SOLVING; SYSTEMATIC REVIEW; TRAINING; TREATMENT OUTCOME; ADULT; AGED; COGNITION DISORDERS; COGNITIVE AGING; COMPARATIVE STUDY; DAILY LIFE ACTIVITY; FEMALE; MALE; MIDDLE AGED; PSYCHOLOGY; VERY ELDERLY;

ACTIVITIES OF DAILY LIVING; ADULT; AGED; AGED, 80 AND OVER; COGNITION; COGNITION DISORDERS; COGNITIVE AGING; CONTROLLED CLINICAL TRIALS AS TOPIC; EXECUTIVE FUNCTION; EXERCISE; FEMALE; HUMANS; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84910605954     PISSN: 08944105     EISSN: 19311559     Source Type: Journal    
DOI: 10.1037/neu0000101     Document Type: Article

References (114)

1. Anderson, P. (2002). Assessment and development of executive function (EF) during childhood. Child Neuropsychology, 8, 71-82. doi:10.1076/chin.8.2.71.8724
2. *Anderson-Hanley, C., Nimon, J., & Westen, S. (2010). Cognitive health benefits of strengthening exercise for community-dwelling older adults. Journal of Clinical and Experimental Neuropsychology, 32, 996-1001. doi:10.1080/13803391003662702
3. Baddeley, A. (1996). The fractionation of working memory. Proceedings of the National Academy of Sciences of the United States of America, 93, 13468-13472. doi:10.1073/pnas.93.24.13468
4. Ball, K., Berch, D., Helmers, K., Jobe, J., Leveck, M., Marsiske, M.,... Willis, S. (2002). Effects of cognitive training interventions with older adults: A randomized controlled trial. Journal of the American Medical Association, 288, 2271-2281. doi:10.1001/jama.288.18.2271
5. Bangert-Drowns, R. L. (1986). Review of developments in meta-analytic method. Psychological Bulletin, 99, 388-399. doi:10.1037/0033-2909.99.3.388
6. *Barry, A., Steinmetz, J., Page, H., & Rodahl, K. (1966). The effects of physical conditioning on older individuals. II. Motor performance and cognitive function. Journal of Gerontology, 21, 192-199.
7. *Blumenthal, J. A., Emery, C. F., Madden, D. J., & George, L. K. (1989). Cardiovascular and behavioral effects of aerobic exercise training in healthy older men and women. Journal of Gerontology, 44, M147-M157. doi:10.1093/geronj/44.5.M147
8. *Borella, E., Carretti, B., Riboldi, F., & De Beni, R. (2010). Working memory training in older adults: Evidence of transfer and maintenance effects. Psychology and Aging, 25, 767-778. doi:10.1037/a0020683
9. Borkowski, J. G., & Burke, J. E. (1996). Theories, models, and measurements of executive functioning: An information processing perspective. In G. R. Lyon & N. A. Krasnegor (Eds.), Attention, memory, and executive function (pp. 235-261). Baltimore, MD: Brookes.
10. *Bottino, C. C., Carvalho, I. M., Alvarez, A. A., Avila, R., Zukauskas, P. R., Bustamante, S. Z.,... Camargo, C. P. (2005). Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients:A pilot study. Clinical Rehabilitation, 19, 861-869. doi:10.1191/0269215505cr911oa
11. Boyle, P. A., Malloy, P. F., Salloway, S., Cahn-Weiner, D. A., Cohen, R., & Cummings, J. L. (2003). Executive dysfunction and apathy predict functional impairment in Alzheimer disease. The American Journal of Geriatric Psychiatry, 11, 214-221. doi:10.1097/00019442-200303000-00012
12. Braver, T. S., & Barch, D. M. (2002). A theory of cognitive control, aging cognition, and neuromodulation. Neuroscience and Biobehavioral Reviews, 26, 809-817. doi:10.1016/S0149-7634(02)00067-2
13. *Brown, A., Liu-Ambrose, T., Tate, R., & Lord, S. (2009). The effect of group-based exercise on cognitive performance and mood in seniors residing in intermediate care and self-care retirement facilities: A randomised controlled trial. British Journal of Sports Medicine, 43, 608-614. doi:10.1136/bjsm.2008.049882
14. *Buiza, C., Etxeberria, I., Galdona, N., González, M., Arriola, E., López de Munain, A.,... Yanguas, J. (2008). A randomized, two-year study of the efficacy of cognitive intervention on elderly people: The Donostia Longitudinal Study. International Journal of Geriatric Psychiatry, 23, 85-94. doi:10.1002/gps.1846
15. Burke, S., & Barnes, C. (2006). Neural plasticity in the ageing brain. Nature Reviews Neuroscience, 7, 30-40. doi:10.1038/nrn1809
16. Cahn-Weiner, D. A., Boyle, P. A., & Malloy, P. F. (2002). Tests of executive function predict instrumental activities of daily living in community-dwelling older individuals. Applied Neuropsychology, 9, 187-191. doi:10.1207/S15324826AN0903_8
17. *Cahn-Weiner, D. A., Malloy, P. F., Rebok, G. W., & Ott, B. R. (2003). Results of a randomized placebo-controlled study of memory training for mildly impaired Alzheimer's disease patients. Applied Neuropsychology, 10, 215-223. doi:10.1207/s15324826an1004_3
18. *Calero, M., & Navarro, E. (2007). Cognitive plasticity as a modulating variable on the effects of memory training in elderly persons. Archives of Clinical Neuropsychology, 22, 63-72. doi:10.1016/j.acn.2006.06.020
19. *Ceccato, E., Vigato, G., Bonetto, C., Bevilacqua, A., Pizziolo, P., Crociani, S.,... Barchi, E. (2012). STAM protocol in dementia: A multicenter, single-blind, randomized, and controlled trial. American Journal of Alzheimer's Disease and Other Dementias, 27, 301-310. doi:10.1177/1533317512452038
20. *Clare, L., Linden, D., Woods, R., Whitaker, R., Evans, S., Parkinson, C., ... Rugg, M. (2010). Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: A single-blind randomized controlled trial of clinical efficacy. The American Journal of Geriatric Psychiatry, 18, 928-939. doi:10.1097/JGP.0b013e3181d5792a
21. Clare, L., Woods, R., Moniz Cook, E., Orrell, M., & Spector, A. (2003). Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database of Systematic Reviews, 4, CD003260.
22. Colcombe, S., & Kramer, A. (2003). Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychological Science, 14, 125-130. doi:10.1111/1467-9280.t01-1-01430
23. Colcombe, S., Kramer, A., Erickson, K., Scalf, P., McAuley, E., Cohen, N., ... Elavsky, S. (2004). Cardiovascular fitness, cortical plasticity, and aging. Proceedings of the National Academy of Sciences of the United States of America, 101(9), 3316-3321. doi:10.1073/pnas.0400266101
24. Conover, W. J. (1999). Practical nonparametric statistics (3rd ed.). New York, NY: Wiley.
25. Cooper, H., Hedges, L. V., & Valentine, J. C. (Eds.). (2009). The handbook of research synthesis and meta-analysis. New York, NY: Russell Sage Foundation.
26. *Craik, F. I. M., Winocur, G., Palmer, H., Binns, M. A., Edwards, M., Bridges, K.,... Stuss, D. T. (2007). Cognitive rehabilitation in the elderly: Effects on memory. Journal of the International Neuropsychological Society, 13, 132-142. doi:10.1017/S1355617707070166
27. Dahlin, E., Nyberg, L., Bäckman, L., & Neely, A. S. (2008). Plasticity of executive functioning in young and older adults: Immediate training gains, transfer, and long-term maintenance. Psychology and Aging, 23, 720-730. doi:10.1037/a0014296
28. Darowski, E. S., Helder, E., Zacks, R. T., Hasher, L., & Hambrick, D. Z. (2008). Age-related differences in cognition: The role of distraction control. Neuropsychology, 22, 638-644. doi:10.1037/0894-4105.22.5.638
29. *Davis, R., Massman, P., & Doody, R. (2001). Cognitive intervention in Alzheimer disease: A randomized placebo-controlled study. Alzheimer Disease and Associated Disorders, 15, 1-9.
30. DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7, 177-188. doi:10.1016/0197-2456(86)90046-2
31. Di, X., Rypma, B., & Biswal, B. B. (2014). Correspondence of executive function related functional and anatomical alterations in aging brain. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 48, 41-50. doi:10.1016/j.pnpbp.2013.09.001
32. Fabre, C., Chamari, K., Mucci, P., Massé-Biron, J., & Préfaut, C. (2002). Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. International Journal of Sports Medicine, 23, 415-421. doi:10.1055/s-2002-33735
33. Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004). An active and socially integrated lifestyle in late life might protect against dementia. The Lancet Neurology, 3, 343-353. doi:10.1016/S1474-4422(04)00767-7
34. Gates, N., & Valenzuela, M. (2010). Cognitive exercise and its role in cognitive function in older adults. Current Psychiatry Reports, 12, 20-27. doi:10.1007/s11920-009-0085-y
35. Goldman-Rakic, P. S. (1996). The prefrontal landscape: Implications of functional architecture for understanding human mentation and the central executive. Philosophical Transactions of the Royal Society of London Series B, Biological sciences, 351, 1445-1453. doi:10.1098/rstb .1996.0129
36. Greenwood, P. M., & Parasuraman, R. (2010). Neuronal and cognitive plasticity: A neurocognitive framework for ameliorating cognitive aging. Frontiers in Aging Neuroscience, 2. doi:10.3389/fnagi.2010.00150
37. Grigsby, J., Kaye, K., Baxter, J., Shetterly, S. M., & Hamman, R. F. (1998). Executive cognitive abilities and functional status among communitydwelling older persons in the San Luis Valley Health and Aging Study. Journal of the American Geriatrics Society, 46, 590-596.
38. Gunning-Dixon, F. M., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: A prospective MRI study. Neuropsychologia, 41, 1929-1941. doi:10.1016/S0028-3932(03)00129-5
39. *Hawkins, H., Kramer, A., & Capaldi, D. (1992). Aging, exercise, and attention. Psychology and Aging, 7, 643-653.
40. Herrmann, N., Chau, S., Kircanski, I., & Lanctot, K. (2011). Current and emerging drug treatment options for Alzheimer's disease: A systematic review. Drugs, 71, 2031-2065. doi:10.2165/11595870-000000000-00000
41. Heyn, P., Abreu, B., & Ottenbacher, K. (2004). The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis. Archives of Physical Medicine and Rehabilitation, 85, 1694-1704. doi:10.1016/j.apmr.2004.03.019
42. Heyn, P. C., Johnsons, K. E., & Kramer, A. F. (2008). Endurance and strength training outcomes on cognitively impaired and cognitively intact older adults: A meta-analysis. The Journal of Nutrition Health and Aging, 12, 401-409. doi:10.1007/BF02982674
43. Huedo-Medina, T., Sánchez-Meca, J., Marín-Martínez, F., & Botella, J. (2006). Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychological Methods, 11, 193-206. doi:10.1037/1082-989X.11.2.193
44. Johnson, J. K., Lui, L. Y., & Yaffe, K. (2007). Executive function, more than global cognition, predicts functional decline and mortality in elderly women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 62, 1134-1141. doi:10.1093/gerona/62.10.1134
45. Jurado, M. B., & Roselli, M. (2007). The elusive nature of executive functions: A review of our current understanding. Neuropsychological Review, 17, 213-233. doi:10.1007/s11065-007-9040-z
46. Karbach, J., & Kray, J. (2009). How useful is executive control training? Age differences in near and far transfer of task-switching training. Developmental Science, 12, 978-990. doi:10.1111/j.1467-7687.2009.00846.x
47. Karr, J. E., Alexander, J. E., & Winningham, R. G. (2011). Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: A review. Nutritional Neuroscience, 14, 216-225. doi:10.1179/2161476830511Y.0000000012
48. *Kimura, K., Obuchi, S., Arai, T., Nagasawa, H., Shiba, Y., Watanabe, S., & Kojima, M. (2010). The influence of short-term strength training on health-related quality of life and executive cognitive function. Journal of Physiological Anthropology, 29, 95-101.
49. *Klusmann, V., Evers, A., Schwarzer, R., Schlattmann, P., Reischies, F. M., Heuser, I., & Dimeo, F. C. (2010). Complex mental and physical activity in older women and cognitive performance: A 6-month randomized controlled trial. The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences, 65, 680-688. doi:10.1093/gerona/glq053
50. Kramer, A. F., & Erickson, K. I. (2007). Capitalizing on cortical plasticity:Influence of physical activity on cognition and brain function. Trends in Cognitive Sciences, 11, 342-348. doi:10.1016/j.tics.2007.06.009
51. Kramer, A. F., Hahn, S., Cohen, N., Banich, M., McAuley, E., Harrison, C.,... Colcombe, A. (1999). Ageing, fitness and neurocognitive function. Nature, 400, 418-419. doi:10.1038/22682
52. Kurz, A. F., Leucht, S., & Lautenschlager, N. T. (2011). The clinical significance of cognition-focused interventions for cognitively impaired older adults: A systematic review of randomized controlled trials. International Psychogeriatrics, 23, 1364-1375. doi:10.1017/S10416102 11001001
53. *Legault, C., Jennings, J. M., Katula, J. A., Dagenbach, D., Gaussoin, S. A., Sink, K. M.,... Espeland, M. A. (2011). Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: The Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial. BMC Geriatrics, 11, 27. doi:10.1186/1471-2318-11-27
54. Lezak, M., Howieson, D. B., Bigler, E. D., & Tranel, D. (2012). Neuropsychological assessment (5th ed.). New York, NY: Oxford University Press.
55. *Liu-Ambrose, T., Donaldson, M., Ahamed, Y., Graf, P., Cook, W., Close, J.,... Khan, K. (2008). Otago home-based strength and balance retraining improves executive functioning in older fallers: A randomized controlled trial. Journal of the American Geriatrics Society, 56, 1821-1830.
56. Liu-Ambrose, T., Nagamatsu, L., Graf, P., Beattie, B., Ashe, M., & Handy, T. (2010). Resistance training and executive functions: A 12-month randomized controlled trial. Archives of Internal Medicine, 170, 170-178. doi:10.1001/archinternmed.2009.494
57. *Liu-Ambrose, T., Nagamatsu, L., Voss, M., Khan, K., & Handy, T. (2012). Resistance training and functional plasticity of the aging brain:A 12-month randomized controlled trial. Neurobiology of Aging, 33, 1690-1698. doi:10.1016/j.neurobiolaging.2011.05.010
58. *Madden, D., Blumenthal, J., Allen, P., & Emery, C. (1989). Improving aerobic capacity in healthy older adults does not necessarily lead to improved cognitive performance. Psychology and Aging, 4, 307-320. doi:10.1037/0882-7974.4.3.307
59. Maher, C., Sherrington, C., Herbert, R., Moseley, A., & Elkins, M. (2003). Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical Therapy, 83, 713-721.
60. *Maki, Y., Ura, C., Yamaguchi, T., Murai, T., Isahai, M., Kaiho, A.,... Yamaguchi, H. (2012). Effects of intervention using a community-based walking program for prevention of mental decline: A randomized controlled trial. Journal of the American Geriatrics Society, 60, 505-510. doi:10.1111/j.1532-5415.2011.03838.x
61. *Margrett, J. A., & Willis, S. L. (2006). In-home cognitive training with older married couples: Individual versus collaborative learning. Aging, Neuropsychology, and Cognition, 13, 173-195. doi:10.1080/138255890969285
62. Marín-Martínez, F., & Sánchez-Meca, J. (1999). Averaging dependent effect sizes in meta-analysis: A cautionary note about procedures. The Spanish Journal of Psychology, 2, 32-38. doi:10.1017/S1138741600005436
63. Martyr, A., & Clare, L. (2012). Executive function and activities of daily living in Alzheimer's disease: A correlational meta-analysis. Dementia and Geriatric Cognitive Disorders, 33, 189-203. doi:10.1159/000338233
64. Mattson, M. (2000). Neuroprotective signaling and the aging brain: Take away my food and let me run. Brain Research, 886, 47-53. doi:10.1016/S0006-8993(00)02790-6
65. Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167-202. doi:10.1146/annurev.neuro.24.1.167
66. Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex "frontal lobe" tasks: A latent variable analysis. Cognitive Psychology, 41, 49-100. doi:10.1006/cogp.1999.0734
67. Moher, D., Liberati, A., Tetzlaff, J., Altman, D., & the PRISMA Group. (2009). Preferred reporting items for systematic reviews and metaanalyses:The PRISMA statement. Annals of Internal Medicine, 151, 264-269. doi:10.7326/0003-4819-151-4-200908180-00135
68. *Molloy, D., Richardson, L., & Crilly, R. (1988). The effects of a threemonth exercise programme on neuropsychological function in elderly institutionalized women: A randomized controlled trial. Age and Ageing, 17, 303-310.
69. *Moro, V., Condoleo, M. T., Sala, F., Pernigo, S., Moretto, G., & Gambina, G. (2012). Cognitive stimulation in a-MCI: An experimental study. American Journal of Alzheimer's Disease and Other Dementias, 27, 121-130. doi:10.1177/1533317512441386
70. Morris, S. B. (2008). Estimating effect sizes from pretest-posttest-control group designs. Organizational Research Methods, 11, 364-386. doi:10.1177/1094428106291059
71. *Moul, J., Goldman, B., & Warren, B. (1995). Physical activity and cognitive performance in the older population. Journal of Aging and Physical Activity, 3, 135-145.
72. Mozolic, J. L., Hayasaka, S., & Laurienti, P. J. (2010). A cognitive training intervention increases resting cerebral blood flow in healthy older adults. Frontiers in Human Neuroscience, 4. doi:10.3389/neuro.09.016.2010
73. *Mozolic, J. L., Long, A. B., Morgan, A. R., Rawley-Payne, M., & Laurienti, P. J. (2011). A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiology of Aging, 32, 655-668. doi:10.1016/j .neurobiolaging.2009.04.013
74. Nigg, J. T. (2000). On inhibition/disinhibition in developmental psychopathology:Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220-246. doi:10.1037/0033-2909.126.2.220
75. *Nouchi, R., Taki, Y., Takeuchi, H., Hashizume, H., Akitsuki, Y., Shigemune, Y.,... Kawashima, R. (2012). Brain training game improves executive functions and processing speed in the elderly: A randomized controlled trial. PloS ONE, 7, e29676. doi:10.1371/journal.pone .0029676
76. *Oken, B., Zajdel, D., Kishiyama, S., Flegal, K., Dehen, C., Haas, M.,... Leyva, J. (2006). Randomized, controlled, six-month trial of yoga in healthy seniors: Effects on cognition and quality of life. Alternative Therapies in Health and Medicine, 12, 40-47.
77. Oswald, W. D., Gunzelmann, T., Rupprecht, R., & Hagen, B. (2006). Differential effects of single versus combined cognitive and physical training with older adults: The SimA study in a 5-year perspective. European Journal of Ageing, 3, 179-192. doi:10.1007/s10433-006-0035-z
78. Park, D. C., & Reuter-Lorenz, P. (2009). The adaptive brain: Aging and neurocognitive scaffolding. Annual Review of Psychology, 60, 173-196. doi:10.1146/annurev.psych.59.103006.093656
79. Pereira, F. S., Yassuda, M. S., Oliveira, A. M., & Forlenza, O. V. (2008). Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment. International Psychogeriatrics, 20, 1104-1115. doi:10.1017/S1041610208007631
80. *Peretz, C., Korczyn, A., Shatil, E., Aharonson, V., Birnboim, S., & Giladi, N. (2011). Computer-based, personalized cognitive training versus classical computer games: A randomized double-blind prospective trial of cognitive stimulation. Neuroepidemiology, 36, 91-99. doi:10.1159/000323950
81. Posner, M. I., & Rothbart, M. K. (2007). Research on attention networks as a model for the integration of psychological science. Annual Review of Psychology, 58, 1-23. doi:10.1146/annurev.psych.58.110405.085516
82. *Powell, R. (1974). Psychological effects of exercise therapy upon institutionalized geriatric mental patients. Journal of Gerontology, 29, 157-161. doi:10.1093/geronj/29.2.157
83. *Quayhagen, M. P., & Quayhagen, M. (1989). Differential effects of family-based strategies on Alzheimer's disease. The Gerontologist, 29, 150-155. doi:10.1093/geront/29.2.150
84. *Quayhagen, M. P., Quayhagen, M., Corbeil, R., Hendrix, R., Jackson, J., Snyder, L., & Bower, D. (2000). Coping with dementia: Evaluation of four nonpharmacologic interventions. International Psychogeriatrics, 12, 249-265. doi:10.1017/S1041610200006360
85. *Quayhagen, M. P., Quayhagen, M., Corbeil, R., Roth, P., & Rodgers, J. (1995). A dyadic remediation program for care recipients with dementia. Nursing Research, 44, 153-159. doi:10.1097/00006199-199505000-00005
86. *Richmond, L. L., Morrison, A. B., Chein, J. M., & Olson, I. R. (2011). Working memory training and transfer in older adults. Psychology and Aging, 26, 813-822. doi:10.1037/a0023631
87. Rosenberg, M. S. (2005). The file-drawer problem revisited: A general weighted method for calculating fail-safe numbers in meta-analysis. Evolution, 59, 464-468. doi:10.1111/j.0014-3820.2005.tb01004.x
88. Rosenthal, R. (1979). The file drawer problem and tolerance for null results. Psychological Bulletin, 86, 638-641. doi:10.1037/0033-2909.86.3.638
89. Rosenthal, R., & Rubin, D. B. (1986). Meta-analytic procedures for combining studies with multiple effect sizes. Psychological Bulletin, 99, 400-406. doi:10.1037/0033-2909.99.3.400
90. Salthouse, T. A., Atkinson, T. M., & Berish, D. E. (2003). Executive functioning as a potential mediator of age-related cognitive decline in normal adults. Journal of Experimental Psychology, 132, 566-594. doi:10.1037/0096-3445.132.4.566
91. *Scherder, E., Van Paasschen, J., Deijen, J., Van Der Knokke, S., Orlebeke, J., Burgers, I.,... Sergeant, J. (2005). Physical activity and executive functions in the elderly with mild cognitive impairment. Aging & Mental Health, 9, 272-280. doi:10.1080/13607860500089930
92. *Schwenk, M., Zieschang, T., Oster, P., & Hauer, K. (2010). Dual-task performances can be improved in patients with dementia: A randomized controlled trial. Neurology, 74, 1961-1968.
93. Seeman, T. E., Miller-Martinez, D. M., Merkin, S., Lachman, M. E., Tun, P. A., & Karlamangla, A. S. (2011). Histories of social engagement and adult cognition: Midlife in the U.S. study. The Journals of Gerontology:Series B: Psychological Sciences and Social Sciences, 66B, i141-i152. doi:10.1093/geronb/gbq091
94. Sitzer, D., Twamley, E., & Jeste, D. (2006). Cognitive training in Alzheimer's disease: A meta-analysis of the literature. Acta Psychiatrica Scandinavica, 114, 75-90. doi:10.1111/j.1600-0447.2006.00789.x
95. Smith, G., Housen, P., Yaffe, K., Ruff, R., Kennison, R., Mahncke, H., & Zelinski, E. (2009). A cognitive training program based on principles of brain plasticity: Results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. Journal of the American Geriatrics Society, 57, 594-603. doi:10.1111/j.1532-5415.2008.02167.x
96. Smith, P., Blumenthal, J., Hoffman, B., Cooper, H., Strauman, T., Welsh-Bohmer, K.,... Sherwood, A. (2010). Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials. Psychosomatic Medicine, 72, 239-252. doi:10.1097/PSY .0b013e3181d14633
97. *Stine-Morrow, E., Parisi, J., Morrow, D., & Park, D. (2008). The effects of an engaged lifestyle on cognitive vitality: A field experiment. Psychology and Aging, 23, 778-786.
98. *Stuss, D., Robertson, I., Craik, F., Levine, B., Alexander, M., Black, S., ... Winocur, G. (2007). Cognitive rehabilitation in the elderly: A randomized trial to evaluate a new protocol. Journal of the International Neuropsychological Society, 13, 120-131. doi:10.1017/S135561770 7070154
99. *Suzuki, T., Shimada, H., Makizako, H., Doi, T., Yoshida, D., Tsutsumimoto, K.,... Park, H. (2012). Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment:A randomized controlled trial. BMC Neurology, 12(128. doi:10.1186/1471-2377-12-128
100. Thom, J. M., & Clare, L. (2011). Rationale for combined exercise and cognition-focused interventions to improve functional independence in people with dementia. Gerontology, 57, 265-275. doi:10.1159/000322198
101. Turner, G. R., & Spreng, R. N. (2012). Executive functions and neurocognitive aging: Dissociable patterns of brain activity. Neurobiology of Aging, 33, 826.e1-826.e13. doi:10.1016/j.neurobiolaging.2011.06.005
102. Valenzuela, M., & Sachdev, P. (2009). Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up. The American Journal of Geriatric Psychiatry, 17, 179-187. doi:10.1097/JGP.0b013e3181953b57
103. van Uffelen, J., Chin A Paw, M., Hopman-Rock, M., & van Mechelen, W. (2008). The effects of exercise on cognition in older adults with and without cognitive decline: A systematic review. Clinical Journal of Sport Medicine, 18(6), 486-500. doi:10.1097/JSM.0b013e3181845f0b
104. *van Uffelen, J., Chinapaw, M., van Mechelen, W., & Hopman-Rock, M. (2008). Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. British Journal of Sports Medicine, 42, 344-351.
105. *Vance, D., Dawson, J., Wadley, V., Edwards, J., Roenker, D., Rizzo, M., & Ball, K. (2007). The accelerate study: The longitudinal effect of speed of processing training on cognitive performance of older adults. Rehabilitation Psychology, 52, 89-96. doi:10.1037/0090-5550.52.1.89
106. Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Trojanowski, J. Q., Shaw, L. M.,... Jack, C. R. (2010). Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology, 75, 143-151. doi:10.1212/WNL.0b013e3181e7ca82
107. Voss, M., Prakash, R., Erickson, K., Basak, C., Chaddock, L., Kim, J.,... Kramer, A. (2010). Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience, 2. doi:10.3389/fnagi.2010.00032
108. *Williams, P., & Lord, S. (1997). Effects of group exercise on cognitive functioning and mood in older women. Australian and New Zealand Journal of Public Health, 21, 45-52.
109. *Williamson, J., Espeland, M., Kritchevsky, S., Newman, A., King, A., Pahor, M., & Miller, M. (2009). Changes in cognitive function in a randomized trial of physical activity: Results of the lifestyle interventions and independence for elders pilot study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64, 688-694.
110. Woods, B., Aguirre, E., Spector, A., & Orrell, M. (2012). Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database of Systematic Reviews. Advance online publication. doi:10.1002/14651858.CD005562.pub2
111. *Yágüez, L., Shaw, K., Morris, R., & Matthews, D. (2011). The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: A pilot study. International Journal of Geriatric Psychiatry, 26, 173-181. doi:10.1002/gps.2510
112. Zaza, S., Wright-De Agüero, L., Briss, P., Truman, B., Hopkins, D., Hennessy, M.,... Pappaioanou, M. (2000). Data collection instrument and procedure for systematic reviews in the guide to community preventive services. Task force on community preventive services. American Journal of Preventive Medicine, 18, 44-74. doi:10.1016/S0749-3797(99)00122-1
113. Zelazo, P., & Müller, U. (2011). Executive function in typical and atypical development. In U. Goswami (Ed.), The Wiley-Blackwell handbook of childhood cognitive development (2nd ed., pp. 574-603). Oxford, UK:Wiley-Blackwell.
114. Zunzunegui, M. V., Alvarado, B. E., Del Ser, T., & Otero, A. (2003). Social networks, social integration, and social engagement determine cognitive decline in community-dwelling Spanish older adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 58, S93-S100. doi:10.1093/geronb/58.2.S93