Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse

Journal of Immunology

Volumn 193, Issue 10, 2014, Pages 4833-4844

  Wong, Andrea Sut Ling ^a,b   Mortin Toth, Steven ^b   Sung, Michael ^b   Canty, Angelo J ^c   Gulban, Omid ^b   Greaves, David R ^d   Danska, Jayne S ^a,b,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; CD47 PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LIGAND; PROTEIN BINDING; PTPNS1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; BONE MARROW CELL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DISEASE COURSE; GENE; GENE EXPRESSION; GENE LOCUS; GENETIC POLYMORPHISM; IDD5 GENE; IDDI3.2 GENE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SINGLE NUCLEOTIDE POLYMORPHISM; SIRPA GENE; T LYMPHOCYTE; TRANSGENE; ANIMAL; CELL PROLIFERATION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; NONOBESE DIABETIC MOUSE; PATHOLOGY; RISK FACTOR; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD47; AUTOIMMUNITY; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENETIC LOCI; HUMANS; IMMUNITY, INNATE; LIGANDS; MICE; MICE, INBRED NOD; MYELOID CELLS; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RISK FACTORS; SIGNAL TRANSDUCTION; TRANSGENES;

EID: 84910111370     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401984     Document Type: Article

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