Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes

Physiological Research

Volumn 63, Issue 4, 2014, Pages 483-490

  Spolcova A ^a   Holubova M ^a   Mikulaskova B ^a   Nagelova V ^a   Stofkova A ^b   Lacinova Z ^b   Jurcovicova J ^b   Haluzik M ^b   Maletinska L ^a   Zelezna B ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

A ZIP mice; Fatty liver; FGF21; GLUT 1; Insulin resistance; Lipodystrophy

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MESSENGER RNA; NEUROPEPTIDE;

ANIMAL; BIOSYNTHESIS; BLOOD; BROWN ADIPOSE TISSUE; EXPERIMENTAL DIABETES MELLITUS; HYPOTHALAMUS; INSULIN RESISTANCE; LIPODYSTROPHY; LIVER; METABOLISM; MOUSE; PANCREAS; SPLEEN;

ADIPOSE TISSUE, BROWN; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FIBROBLAST GROWTH FACTORS; HYPOTHALAMUS; INSULIN RESISTANCE; LIPODYSTROPHY; LIVER; MICE; NEUROPEPTIDES; PANCREAS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, MESSENGER; SPLEEN;

EID: 84910053633     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. DOMINGO P, GALLEGO-ESCUREDO JM, DOMINGO JC, GUTIÉRREZ MDEL M, MATEO MG, FERNÁNDEZ I, VIDAL F, GIRALT M, VILLARROYA F: Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS 24: 2629-2637, 2010.
2. DUSHAY J, CHUI PC, GOPALAKRISHNAN GS, VARELA-REY M, CRAWLEY M, FISHER FM, BADMAN MK, MARTINEZ-CHANTAR ML, MARATOS-FLIER E: Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139: 456-463, 2010.
3. FISHER FM, CHUI PC, ANTONELLIS PJ, BINA HA, KHARITONENKOV A, FLIER JS, MARATOS-FLIER E: Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 59: 2781-2789, 2010.
4. HALUZÍK M, DIETZ KR, KIM JK, MARCUS-SAMUELS B, SHULMAN GI, GAVRILOVA O, REITMAN ML: Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes 51: 2113-2118, 2002.
5. HOLLAND WL, ADAMS AC, BROZINICK JT, BUI HH, MIYAUCHI Y, KUSMINSKI CM, BAUER SM, WADE M, SINGHAL E, CHENG CC, VOLK K, KUO MS, GORDILLO R, KHARITONENKOV A, SCHERER PE: An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab 17: 790-797, 2013.
6. HOLUBOVÁ M, ŠPOLCOVÁ A, DEMIANOVÁ Z, SÝKORA D, FEHRENTZ JA, MARTINEZ J, STOFKOVA A, JURČOVIČOVÁ J, DRÁPALOVÁ J, LACINOVÁ Z, HALUZÍK M, ŽELEZNÁ B, MALETÍNSKÁ L: Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice. Physiol Res 62: 435-444, 2013.
7. HSUCHOU H, PAN W, KASTIN AJ: The fasting polypeptide FGF21 can enter brain from blood. Peptides 28: 2382-2386, 2007.
8. IIZUKA K, TAKEDA J, HORIKAWA Y: Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett 583: 2882-2886, 2009.
9. INAGAKI T, DUTCHAK P, ZHAO G, DING X, GAUTRON L, PARAMESWARA V, LI Y, GOETZ R, MOHAMMADI M, ESSER V, ELMQUIST JK, GERARD RD, BURGESS SC, HAMMER RE, MANGELSDORF DJ, KLIEWER SA: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5: 415-425, 2007.
10. ISHIDA Y, SAKAHARA S, TSUTSUI C, KAIYA H, SAKATA I, ODA S, SAKAI T: Identification of ghrelin in the house musk shrew (Suncus murinus): cDNA cloning, peptide purification and tissue distribution. Peptides 30: 982-990, 2009.
11. ITO S, KINOSHITA S, SHIRAISHI N, NAKAGAWA S, SEKINE S, FUJIMORI T, NABESHIMA YI: Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev 98: 115-119, 2000.
12. KHARITONENKOV A, SHIYANOVA TL, KOESTER A, FORD AM, MICANOVIC R, GALBREATH EJ, SANDUSKY GE, HAMMOND LJ, MOYERS JS, OWENS RA, GROMADA J, BROZINICK JT, HAWKINS ED, WROBLEWSKI VJ, LI DS, MEHRBOD F, JASKUNAS SR, SHANAFELT AB: FGF-21 as a novel metabolic regulator. J Clin Invest 115: 1627-1635, 2005.
13. KIM JK, GAVRILOVA O, CHEN Y, REITMAN ML, SHULMAN GI: Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 275: 8456-8460, 2000.
14. KUROSU H, CHOI M, OGAWA Y, DICKSON AS, GOETZ R, ELISEENKOVA AV, MOHAMMADI M, ROSENBLATT KP, KLIEWER SA, KURO-O M: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF2. J Biol Chem 282: 26687-26695, 2007.
15. LIN Z, TIAN H, LAM KS, LIN S, HOO RC, KONISHI M, ITOH N, WANG Y, BORNSTEIN SR, XU A, LI X: Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab 17: 779-789, 2013.
16. LINDEGAARD B, HVID T, GRØNDAHL T, FROSIG C, GERSTOFT J, HOJMAN P, PEDERSEN BK: Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. PLoS One 8: e55632, 2013.
17. MALETÍNSKÁ L, MATYŠKOVÁ R, MAIXNEROVÁ J, SÝKORA D, PÝCHOVÁ M, ŠPOLCOVÁ A, BLECHOVÁ M, DRÁPALOVÁ J, LACINOVÁ Z, HALUZÍK M, ŽELEZNÁ B: The Peptidic GHS-R antagonist [DLys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity. Mol Cell Endocrinol 343: 55-62, 2011.
18. MASHILI FL, AUSTIN RL, DESHMUKH AS, FRITZ T, CAIDAHL K, BERGDAHL K, ZIERATH JR, CHIBALIN AV, MOLLER DE, KHARITONENKOV A, KROOK A: Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev 27: 286-297, 2011.
19. MOITRA J, MASON MM, OLIVE M, KRYLOV D, GAVRILOVA O, MARCUS-SAMUELS B, FEIGENBAUM L, LEE E, AOYAMA T, ECKHAUS M, REITMAN ML, VINSON C: Life without white fat: a transgenic mouse. Genes Dev 12: 3168-3181, 1998.
20. NAKAZATO M, MURAKAMI N, DATE Y, KOJIMA M, MATSUO H, KANGAWA K, MATSUKURA S: A role for ghrelin in the central regulation of feeding. Nature 409: 194-198, 2001.
21. VÉNIANT MM, HALE C, HELMERING J, CHEN MM, STANISLAUS S, BUSBY J, VONDERFECHT S, XU J, LLOYD DJ: FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One 7: e40164, 2012.
22. YANG C, JIN C, LI X, WANG F, MCKEEHAN WL, LUO Y: Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One 7: e33870, 2012a.
23. YANG C, WANG C, YE M, JIN C, HE W, WANG F, MCKEEHAN WL, LUO Y: Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutr Metab (Lond) 9: 94, 2012b.
24. YANG C, LU W, LIN T, YOU P, YE M, HUANG Y, JIANG X, WANG C, WANG F, LEE MH, YEUNG SC, JOHNSON RL, WEI C, TSAI RY, FRAZIER ML, MCKEEHAN WL, LUO Y: Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol 13: 67, 2013.