A recurrent activating PLCG1 mutation in cardiac angiosarcomas increases apoptosis resistance and invasiveness of endothelial cells

Cancer Research

Volumn 74, Issue 21, 2014, Pages 6173-6183

  Kunze, Kristin ^a   Spieker, Tilmann ^b   Gamerdinger, Ulrike ^a   Nau, Kerstin ^a   Berger, Johannes ^a   Dreyer, Thomas ^a   Sindermann, Jürgen R ^c   Hoffmeier, Andreas ^c   Gattenlöhner, Stefan ^a   Bräuninger, Andreas ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b ST FRANZISKUS HOSPITAL   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; COFILIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE C; RAF PROTEIN; PHOSPHOLIPASE C GAMMA; PLCG1 PROTEIN, HUMAN; VASCULOTROPIN RECEPTOR 2;

ANGIOSARCOMA; APOPTOSIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME 1Q; CHROMOSOME 4; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; HEART TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KDR GENE; KIT GENE; MLL2 GENE; NONSENSE MUTATION; ONCOGENE; PLCG1 GENE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE; WILD TYPE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; TUMOR INVASION;

APOPTOSIS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEART NEOPLASMS; HEMANGIOSARCOMA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MUTATION; NEOPLASM INVASIVENESS; PHOSPHOLIPASE C GAMMA; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84910020229     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1162     Document Type: Article

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