Elevated circulating pigment epithelium-derived factor predicts the progression of diabetic nephropathy in patients with type 2 diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 11, 2014, Pages E2169-E2177

  Hui, Elaine ^a   Yeung, Chun Yip ^a   Lee, Paul C H ^a   Woo, Yu Cho ^a   Fong, Carol H Y ^a   Chow, Wing Sun ^a   Xu, Aimin ^a,b   Lam, Karen S L ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; C REACTIVE PROTEIN; HEMOGLOBIN A1C; PIGMENT EPITHELIUM DERIVED FACTOR; EYE PROTEIN; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; SERINE PROTEINASE INHIBITOR;

ADULT; AGE; ALBUMINURIA; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DETERIORATION; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; GLOMERULUS FILTRATION RATE; HONG KONG; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SEX; STAGING; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; AGED; BLOOD; MIDDLE AGED; REGISTER; RENAL INSUFFICIENCY, CHRONIC; RISK FACTOR;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; EYE PROTEINS; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; REGISTRIES; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; SERPINS;

EID: 84909995935     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2235     Document Type: Article

References (38)

1. Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science. 1999;285: 245-248.
2. Boehm BO, Lang G, Volpert O, et al. Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy. Diabetologia. 2003;46: 394-400.
3. Wang JJ, Zhang SX, Lu K, et al. Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy. Diabetes. 2005;54: 243-250.
4. Wang JJ, Zhang SX, Mott R, et al. Salutary effect of pigment epithelium- derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Diabetes. 2006;55: 1678-1685.
5. Awad AS, Gao T, Gvritishvili A, et al. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. Am J Physiol Renal Physiol. 2013;305: F891-F900.
6. Wang JJ, Zhang SX, Mott R, et al. Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. Am J Physiol Renal Physiol. 2008;294: F1166-F1173.
7. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl 1): S55-S60.
8. Chapter 2: definition, identification, and prediction of CKD progression. Kidney Int Suppl. 2013;3: 63-72.
9. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann InternMed. 2006; 145: 247-254.
10. Stevens PE, Levin A; Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the Kidney Disease: Improving Global Outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158: 825-830.
11. Ma YC, Zuo L, Chen JH, et al. Improved GFR estimation by combined creatinine and cystatin C measurements. Kidney Int. 2007; 72: 1535-1542.
12. Levey AS, Stevens LA, Schmid CH, et al.Anew equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150: 604-612.
13. Standards of medical care in diabetes-2013. Diabetes Care. 2013; 36(Suppl 1): S11-S66.
14. Stejskal D, Karpísek M, Svesták M, Hejduk P, Sporová L, Kotolová H. Pigment epithelium-derived factor as a new marker of metabolic syndrome in Caucasian population. J Clin Lab Anal. 2010; 24: 17-19.
15. Chen C, Tso AW, Law LS, et al. Plasma level of pigment epithelium- derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study. J Clin Endocrinol Metab. 2010;95: 5074-5081.
16. Tahara N, Yamagishi S, Tahara A, et al. Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans. Atherosclerosis. 2011;219: 311-315.
17. Wang F, Ma X, Zhou M, et al. Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease. Cardiovasc Diabetol. 2013;12: 56.
18. Yamagishi S, Matsui T, Adachi H, Takeuchi M. Positive association of circulating levels of advanced glycation end products (AGEs) with pigment epithelium-derived factor (PEDF) in a general population. Pharmacol Res. 2010;61: 103-107.
19. Shiga Y, Miura S, Mitsutake R, Yamagishi S, Saku K. Significance of plasma levels of pigment epithelium-derived factor as determined by multidetector row computed tomography in patients with mild chronic kidney disease and/or coronary artery disease. J Int Med Res. 2011;39: 880-890.
20. Matsuyama K, Ogata N, Matsuoka M, et al. Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy. Mol Vis. 2008;14: 992-996.
21. Chen HB, Jia WP, Lu JX, et al. [Change and significance of serum pigment epithelium-derived factor in type 2 diabetic nephropathy]. Zhonghua Yi Xue Za Zhi. 2007;87: 1230-1233.
22. Ogata N, Matsuoka M, Matsuyama K, et al. Plasma concentration of pigment epithelium-derived factor in patients with diabetic retinopathy. J Clin Endocrinol Metab. 2007;92: 1176-1179.
23. Ide Y, Matsui T, Ishibashi Y, Takeuchi M, Yamagishi S. Pigment epithelium-derived factor inhibits advanced glycation end productelicited mesangial cell damage by blocking NF-kappaB activation. Microvasc Res. 2010;80: 227-232.
24. Maeda S, Matsui T, Takeuchi M, et al. Pigment epithelium-derived factor (PEDF) inhibits proximal tubular cell injury in early diabetic nephropathy by suppressing advanced glycation end products (AGEs)-receptor (RAGE) axis. Pharmacol Res. 2011;63: 241-248.
25. Ishibashi Y, Matsui T, Ohta K, et al. PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation. Microvasc Res. 2013;85: 54-58.
26. Stieger N, Worthmann K, Schiffer M. The role of metabolic and haemodynamic factors in podocyte injury in diabetes. Diabetes Metab Res Rev. 2011;27: 207-215.
27. Jenkins A, Zhang SX, Gosmanova A, et al. Increased serum pigment epithelium derived factor levels in type 2 diabetes patients. Diabetes Res Clin Pract. 2008;82: e5-e7.
28. Famulla S, Lamers D, Hartwig S, et al. Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells. Int J Obes (Lond). 2011;35: 762-772.
29. Chen C, Tso AW, Cheung BM, et al. Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study. Clin Endocrinol (Oxf). 2012;76: 506-513.
30. Nakamura K, Yamagishi S, Adachi H, Kurita-Nakamura Y, Matsui T, Inoue H. Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes. Diabetes Metab Res Rev. 2009;25: 52-56.
31. Yoshida T, Yamagishi S, Nakamura K, et al. Pigment epitheliumderived factor (PEDF) ameliorates advanced glycation end product (AGE)-induced hepatic insulin resistance in vitro by suppressing Rac-1 activation. Horm Metab Res. 2008;40: 620-625.
32. Maeda S, Matsui T, Takeuchi M, Yamagishi S. Pigment epitheliumderived factor (PEDF) blocks advanced glycation end products (AGEs)-RAGE-induced suppression of adiponectin mRNA level in adipocytes by inhibitingNADPHoxidase-mediated oxidative stress generation. Int J Cardiol. 2011;152: 408-410.
33. Crowe S, Wu LE, Economou C, et al. Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab. 2009; 10: 40-47.
34. Chen H, Zheng Z, Li R, et al. Urinary pigment epithelium-derived factor as a marker of diabetic nephropathy. Am J Nephrol. 2010; 32: 47-56.
35. Turin TC, Coresh J, Tonelli M, et al. One-year change in kidney function is associated with an increased mortality risk. Am J Nephrol. 2012;36: 41-49.
36. Turin TC, Coresh J, Tonelli M, et al. Short-term change in kidney function and risk of end-stage renal disease. Nephrol Dial Transplant. 2012;27: 3835-3843.
37. Jenkins AJ, Fu D, Azar M, et al. Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients. J Diabetes Complications. 2014;28: 353-359.
38. Yu JY, An XF, Liu JS, et al. Plasma sRAGE is not associated with urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage. Diabetes Res Clin Pract. 2010;87: 157-160.