The expression of GPR109A, NF-κB and IL-1β in peripheral blood leukocytes from patients with type 2 diabetes

Annals of Clinical and Laboratory Science

Volumn 44, Issue 4, 2014, Pages 443-448

  Liu, Fengxiu ^a,b   Fu, Yucai ^b   Wei, Chiju ^b   Chen, Yongru ^a   Ma, Shuhua ^a   Xu, Wencan ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

GPR109A; IL 1 ; NF B; Pancreatic islet cell; Peripheral blood leukocytes; Type 2 diabetes

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN GPR109A; UNCLASSIFIED DRUG; CHOLESTEROL; GLUCOSE BLOOD LEVEL; HCAR2 PROTEIN, HUMAN; NICOTINIC RECEPTOR;

ADULT; AGED; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DIABETIC PATIENT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GRANULOCYTE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; LEUKOCYTE; LIPID METABOLISM; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; BLOOD; DIET RESTRICTION; GENETICS; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST; PATHOLOGY;

ADULT; AGED; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; HUMANS; INTERLEUKIN-1BETA; LEUKOCYTES; MALE; MIDDLE AGED; NF-KAPPA B; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 84909994277     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Schaub A, Futterer APfeffer K. PUMA-G, an IFN-gammainducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur J Immunol 2001; 31:3714-3725.
2. Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, Hiyama H, Matsuo A,.Matsushime H, Furuichi K. Molecular identification of nicotinic acid receptor. Biochem Biophys Res Commun 2003; 303:364-369.
3. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003; 9:352-355.
4. Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB. Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem 2003; 278:9869-9874.
5. Martin PM, Ananth S, Cresci G, Roon P, Smith S, Ganapathy V. Expression and localization of GPR109A (PUMA-G/ HM74A) mRNA and protein in mammalian retinal pigmentepithelium. Mol Vis 2009; 15:362-372.
6. Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 2012; 53:2208-2217.
7. Daimon M, Oizumi TKato T. Decreased serum levels of adiponectin as a risk for development of type 2 diabetes, and impaired glucose tolerance as a risk for stroke--the Funagata study. Nihon Rinsho 2012; 70 Suppl 3:256-259.
8. Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao GJudd RL. Niacin stimulates adiponectin secretion through the GPR109A receptor. Am J Physiol Endocrinol Metab 2009; 296:E549-558.
9. Li HM, Zhang M, Xu ST, Li DZ, Zhu LY, Peng SW, Chen GQ, Martin PM, Ganapathy V, Wei CJ. Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet beta cells. Pancreas 2011; 40:615-621.
10. Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V, Abdel Khalek AK, Amiral J, Tritschler H, Ritz E, Wahl P, Ziegler R, Bierhaus A, Nawroth PP. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia 1999; 42:222-232.
11. Kelly MK, Brown JMThong YH. Neutrophil and monocyte adherence in diabetes mellitus, alcoholic cirrhosis, uraemia and elderly patients. Int Arch Allergy Appl Immunol 1985; 78:132-138.
12. Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, Mantovani A, Rothe M, Muzio M, Arditi M. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin- 1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 1999; 274:7611-7614.
13. Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N. Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes 2006; 55:760-767.
14. Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, BrowningDD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V. GPR109A is a G-proteincoupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res 2009; 69:2826-2832.
15. Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY. Interleukin-1- receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007; 356:1517-1526.
16. Hernandez-Mijares A, Rocha M, Apostolova N, Borras C, Jover A, Banuls C, Sola E, Victor VM. Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients. Free Radic Biol Med 2011; 50:1215-1221.