Synthesis and characterization of chitosan quaternary ammonium salt and its application as drug carrier for ribavirin

Drug Delivery

Volumn 21, Issue 7, 2014, Pages 548-552

  Li, Si Dong ^a   Li, Pu Wang ^b   Yang, Zi Ming ^b   Peng, Zheng ^b   Quan, Wei Yan ^a   Yang, Xi Hong ^a   Yang, Lei ^a   Dong, Jing Jing ^a  

^a GUANGDONG OCEAN UNIVERSITY   (China)

^b INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY   (China)

Author keywords

Chemical modification; Chitosan; Drug delivery system; Nanoparticles; Ribavirin

Indexed keywords

CHITOSAN; QUATERNARY AMMONIUM DERIVATIVE; RIBAVIRIN; TRIMETHYLAMMONIUM SALT DERIVATIVE; TRIPOLYPHOSPHATE; ANTIVIRUS AGENT; DRUG CARRIER; N-TRIMETHYL CHITOSAN CHLORIDE; NANOPARTICLE;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; ENCAPSULATION; EXPERIMENTAL DESIGN; IN VITRO STUDY; PARTICLE SIZE; SUSTAINED DRUG RELEASE; SYNTHESIS; CHEMISTRY; MEDICINAL CHEMISTRY; PROCEDURES; X RAY DIFFRACTION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG CARRIERS; NANOPARTICLES; RIBAVIRIN; X-RAY DIFFRACTION;

EID: 84909988829     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2013.853708     Document Type: Article

References (29)

1. Braye FM, Stefani A, Venet E, et al. (2001). Grafting of large pieces of human reconstructed skin in a porcine model. Brit J Plast Surg 54: 532-8.
2. Deng CM, He LZ, Zhao M, et al. (2007). Biological properties of the chitosan-gelatin sponge wound dressing. Carbohydr Polym 69:583-9.
3. Di Colo G, Burgalassi S, Zambito Y, et al. (2004). Effects of different N-trimethylchitosans on in vitro/in vivo ofloxacin transcorneal permeation. J Pharm Sci 93:2851-62.
4. Dodance V, Vilivalam VD. (1998). Pharmaceutical applications of chitosan. Pharm Sci Technol Today 1:246-53.
5. Domard A, Rinaudo M, Terrassin C. (1986). New method for the quaternization of chitosan. Int J Biol Macromol 8:105-7.
6. Douglas B, Márcia RM, Fauze AA, et al. (2012). N, N, N-trimethyl chitosan nanoparticles as a vitamin carrier system. Food Hydrocolloid 27:487-93.
7. Giuseppina S, Bonferoni MC, Rossi S, et al. (2007). Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex-vivo (excised rat jejunum) models. Eur J Pharm Biopharm 65:68-77.
8. Hamman JH, Stander M, Kotzé AF. (2002). Effect of the degree of quternization of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. Int J Pharm 232: 235-42.
9. Helander IM, Nurmiaho-Lassila EL, Ahvenainen R, et al. (2001). Chitosan disrupts the barrier properties of the outer membrane of Gram-negative bacteria. Int J Food Microbiol 71:235-44.
10. Hirano S, Seino H, Akiyama Y, Nonaka I. (1990). Chitosan: a biocompatible materials for oral and intravenous administration. New York: Plenum Publishing Co, 235-42.
11. Jae HP, Yong WC, Hesson C, et al. (2003). Synthesis and characterization of sugar-bearing chitosan derivatives: aqueous solubility and biodegradability. Biomacromolecules 4:1087-91.
12. Li HB, Du YM, Wu XJ, Zhan HY. (2004). Effect of molecular weight and degree of substitution of quaternary chitosan on its absorption and flocculation properties for potential retention-acids in alkaline papermaking.Colloids Surf A 242:1-8.
13. Lim SH, Hudon SM. (2003). Review of chiyosan and its derivatives as antimicrobial agents and their uses as textile chemicals. J Macromol Sci Pol R C43:223-69.
14. Lim SH, Samuel M. (2004). Hudson. Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group. Carbohydr Res 339:313-9.
15. Liu J, Li HX, Chen DQ, et al. (2011). In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel. Drug Deliv 18:181-9.
16. Liu XF, Guan YL, Yang DZ, et al. (2001). Antibacterial action of chitosan and carboxymethylated chitosan. J Appl Polym Sci 79:1324-35.
17. Mi FL, Shyu SS, Kuan CY, et al. (1999). Chitosan-polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. I. Enzymatic hydrolysis of polymer. J Appl Polym Sci 74:1868-79.
18. Ou CY, Li SD, Li CP, et al. (2008). Effect of cupric ion on thermal degradation of chitosan. J Appl Polym Sci 109:957-62.
19. Prabaharan M, Reis RL, Mano JF. (2007). Carboxymethyl chitosan-graftphosphatidylethanolamine: amphiphilic matrices for controlled drug delivery. React Funct Polym 67:43-52.
20. Sarmento B, Ferreira D, Veiga F, Ribeiro A. (2006). Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pregelation through DSC and FTIR studies. Carbohydr Polym 66:1-7.
21. Shahidi F, Arachchi JKV, Jeon YJ. (1999). Food applications of chitin and chitosans. Trend Food Sci Tech 10:37-51.
22. Sonia T, Sharma C. (2011). Chitosan and its derivatives for drug delivery perspective. Adv Polym Sci 243:23-54.
23. Thanou M, Florea BI, Geldof M, et al. (2002). Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials 23:153-9.
24. Trapani A, Garcia-Fuentes M, Alonso MJ. (2008). Novel drug nanocarriers combining hydrophilic cyclodextrins and chitosan. Nanotechnology 19:1-10.
25. Tsai GJ, Su WH. (1999). Antibacterial activity of shrimp chitosan against Escherichia coli. J Food Protect 62:239-43.
26. Vila A, Sánchez A, Janes K, et al. (2004). Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm 57:123-31.
27. Xu YM, Du YM. (2003). Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm 250: 215-26.
28. Xu YM, Du YM, Huang RH, Gao LP. (2003). Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticles as a protein carrier. Biomaterials 24: 5015-22.
29. Yuan XB, Li H, Yuan YB. (2006). Preparation of cholesterol-modified chitosan self-aggregated nanoparticles for delivery of drugs to ocular surface. Carbohydr Polym 65:337-45.