Ski diminishes TGF-β1-induced myofibroblast phenotype via up-regulating Meox2 expression

Experimental and Molecular Pathology

Volumn 97, Issue 3, 2014, Pages 542-549

  Chen, Zhaowei ^a   Li, Wenjing ^a   Ning, Yan ^a   Liu, Tong ^a   Shao, Jingxiang ^a   Wang, Yaojun ^b  

^a Liaocheng Hospital   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Expression of Meox2; Ski; TGF 1

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA SMOOTH MUSCLE ACTIN; CELL PROTEIN; MEOX1 PROTEIN; MEOX2 PROTEIN; MESSENGER RNA; SKI PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; ZEB2 PROTEIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; MEOX2 PROTEIN, HUMAN; ONCOPROTEIN; SKI PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE REPRESSION; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; MYOFIBROBLAST; PATHOGENESIS; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKI GENE; SKIN FIBROBLAST; SKIN FIBROSIS; TRANSFORMING GROWTH FACTOR BETA1 GENE; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; CELL CULTURE; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; METABOLISM; PHYSIOLOGY;

BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CICATRIX, HYPERTROPHIC; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; MYOFIBROBLASTS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; WOUND HEALING;

EID: 84909987042     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.11.002     Document Type: Article

References (38)

1. Akiyoshi S., Inoue H., Hanai J.-i., et al. c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads. J. Biol. Chem. 1999, 274:35269-35277.
2. Broughton G., Janis J.E., Attinger C.E. The basic science of wound healing. Plast. Reconstr. Surg. 2006, 117:12S-34S.
3. Carthy J.M., Garmaroudi F.S., Luo Z., et al. Wnt3a induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenin-dependent manner. PLoS One 2011, 6:e19809.
4. Chen Y., Banda M., Speyer C.L., et al. Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol. Cell. Biol. 2010, 30:3902-3913.
5. Colwell A.S., Longaker M.T., Lorenz H.P. Fetal wound healing. Front. Biosci. 2003, 8:s1240-s1248.
6. Colwell A.S., Longaker M.T., Lorenz H.P. Mammalian fetal organ regeneration. Adv. Biochem. Eng. Biotechnol. 2005, 93:83-100.
7. Comijn J., Berx G., Vermassen P., et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 2001, 7:1267-1278.
8. Crider B.J., Risinger G.M., Haaksma C.J., et al. Myocardin-related transcription factors A and B are key regulators of TGF-β1-induced fibroblast to myofibroblast differentiation. J. Investig. Dermatol. 2011, 131:2378-2385.
9. Cunnington R.H., Wang B., Ghavami S., et al. Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility. Am. J. Physiol. Cell Physiol. 2011, 300:C176-C186.
10. Cunnington R.H., Northcott J.M., Ghavami S., et al. The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype. J. Cell Sci. 2014, 127:40-49.
11. Czubryt M.P. Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogenesis Tissue Repair 2012, 5:19.
12. Daskalopoulos E.P., Janssen B., Blankesteijn W.M. Myofibroblasts in the infarct area: concepts and challenges. Microsc. Microanal. 2012, 18:35-49.
13. Ferguson M.W., Duncan J., Bond J., et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. Lancet 2009, 373:1264-1274.
14. Ferrand N., Atfi A., Prunier C. The oncoprotein c-Ski functions as a direct antagonist of the transforming growth factor-β type I receptor. Cancer Res. 2010, 70:8457-8466.
15. Gurtner G.C., Werner S., Barrandon Y., et al. Wound repair and regeneration. Nature 2008, 453:314-321.
16. Henderson E. The potential effect of fibroblast senescence on wound healing and the chronic wound environment. J. Wound Care 2006, 15:315.
17. Kim B.C., Kim H.T., Park S.H., et al. Fibroblasts from chronic wounds show altered TGF-β-signaling and decreased TGF-β type II receptor expression. J. Cell. Physiol. 2003, 195:331-336.
18. Klass B., Grobbelaar A., Rolfe K. Transforming growth factor β1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance. Postgrad. Med. J. 2009, 85:9-14.
19. Krein P.M., Winston B.W. Roles for insulin-like growth factor I and transforming growth factor-β in fibrotic lung disease. CHEST J. 2002, 122:289S-293S.
20. Li P., Liu P., Xiong R.P., et al. Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear. J. Pathol. 2011, 223:659-671.
21. Li J., Li P., Zhang Y., et al. Upregulation of Ski in fibroblast is implicated in the peroxisome proliferator-activated receptor delta-mediated wound healing. Cell. Physiol. Biochem. 2012, 30:1059-1071.
22. Li J., Li P., Zhang Y., et al. c-Ski inhibits the proliferation of vascular smooth muscle cells via suppressing Smad3 signaling but stimulating p38 pathway. Cell. Signal. 2013, 25:159-167.
23. Liu X., Li P., Chen X.Y., et al. c-Ski promotes skin fibroblast proliferation but decreases type I collagen: implications for wound healing and scar formation. Clin. Exp. Dermatol. 2010, 35:417-424.
24. Nagata M., Goto K., Ehata S., et al. Nuclear and cytoplasmic c-Ski differently modulate cellular functions. Genes Cells 2006, 11:1267-1280.
25. Nall A.V., Brownlee R.E., Colvin C.P., et al. Transforming growth factor {beta} 1 improves wound healing and random flap survival in normal and irradiated rats. Arch. Otolaryngol. Head Neck Surg. 1996, 122:171.
26. Pardali K., Kurisaki A., Morén A., et al. Role of Smad proteins and transcription factor Sp1 in p21Waf1/Cip1 regulation by transforming growth factor-β. J. Biol. Chem. 2000, 275:29244-29256.
27. Parsonage G., Filer A.D., Haworth O., et al. A stromal address code defined by fibroblasts. Trends Immunol. 2005, 26:150-156.
28. Pastar I., Stojadinovic O., Krzyzanowska A., et al. Attenuation of the transforming growth factor β-signaling pathway in chronic venous ulcers. Mol. Med. 2010, 16:92.
29. Roberts A.B., Sporn M.B., Assoian R.K., et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. 1986, 83:4167-4171.
30. Sarrazy V., Billet F., Micallef L., et al. Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen. 2011, 19:s10-s15.
31. Shah M., Foreman D.M., Ferguson M. Neutralising antibody to TGF-beta 1, 2 reduces cutaneous scarring in adult rodents. J. Cell Sci. 1994, 107:1137-1157.
32. Sutrave P., Kelly A., Hughes S. Ski can cause selective growth of skeletal muscle in transgenic mice. Genes Dev. 1990, 4:1462-1472.
33. Sutrave P., Copeland T., Showalter S., et al. Characterization of chicken c-Ski oncogene products expressed by retrovirus vectors. Mol. Cell. Biol. 1990, 10:3137-3144.
34. Suwanmanee S., Kitisin T., Luplertlop N. In vitro screening of 10 edible Thai plants for potential antifungal properties. Evid. Based Complement. Alternat. Med. 2014, 2014:138587.
35. Suzuki H., Yagi K., Kondo M., et al. c-Ski inhibits the TGF-β signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. Oncogene 2004, 23:5068-5076.
36. Valcourt U., Thuault S., Pardali K., et al. Functional role of Meox2 during the epithelial cytostatic response to TGF-β. Mol. Oncol. 2007, 1:55-71.
37. Wood F. Tissue engineering of skin. Clin. Plast. Surg. 2012, 39:21-32.
38. Xu W., Angelis K., Danielpour D., et al. Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor. Proc. Natl. Acad. Sci. 2000, 97:5924-5929.