Topical intrawound application of vancomycin powder in addition to intravenous administration of antibiotics: A meta-analysis on the deep infection after spinal surgeries

Orthopaedics and Traumatology: Surgery and Research

Volumn 100, Issue 7, 2014, Pages 785-789

  Xiong, L ^a   Pan, Q ^b   Jin, G ^b   Xu, Y ^b   Hirche, C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

Deep infection; Intrawound; Spine; Vancomycin

Indexed keywords

ANTIBIOTIC AGENT; CEFAZOLIN; CEFUROXIME; CEPHALOSPORIN; CIPROFLOXACIN; CLINDAMYCIN; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN; ANTIINFECTIVE AGENT; POWDER;

ADD ON THERAPY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; FOLLOW UP; HUMAN; META ANALYSIS; POSTOPERATIVE INFECTION; POWDER; SPINE SURGERY; SURGICAL INFECTION; SURGICAL WOUND; ADVERSE EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; ORTHOPEDIC SURGERY; SPINAL DISEASES; SURGICAL WOUND INFECTION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; HUMANS; INJECTIONS, INTRAVENOUS; ORTHOPEDIC PROCEDURES; POWDERS; SPINAL DISEASES; SURGICAL WOUND INFECTION; VANCOMYCIN;

EID: 84909964261     PISSN: None     EISSN: 18770568     Source Type: Journal    
DOI: 10.1016/j.otsr.2014.05.022     Document Type: Article

References (23)

1. Lew D.P., Waldvogel F.A. Osteomyelitis. Lancet 2004, 364:369-379.
2. Rechtine G.R., Bono P.L., Cahill D., Bolesta M.J., Chrin A.M. Postoperative wound infection after instrumentation of thoracic and lumbar fractures. J Orthop Trauma 2001, 15:566-569.
3. Collins I., Wilson-MacDonald J., Chami G., Burgoyne W., Vineyakam P., Berendt T., et al. The diagnosis and management of infection following instrumented spinal fusion. Eur Spine J 2008, 17:445-450.
4. Schimmel J.J.P., Horsting P.P., de Kleuver M., Wonders G., van Limbeek J. Risk factors for deep surgical site infections after spinal fusion. Eur Spine J 2010, 19:1711-1719.
5. O'Neill K.R., Smith J.G., Abtahi A.M., Archer K.R., Spengler D.M., McGirt M.J., et al. Reduced surgical site infections in patients undergoing posterior spinal stabilization of traumatic injuries using vancomycin powder. Spine J 2011, 11:641-646.
6. Muilwijk J., Walenkamp G.H.I.M., Voss A., Wille J.C., van den Hof S. Random effect modelling of patient-related risk factors in orthopaedic procedures: results from the Dutch nosocomial infection surveillance network "PREZIES". J Hosp Infect 2006, 62:319-326.
7. Kirkland K.B., Briggs J.P., Trivette S.L., Wilkinson W.E., Sexton D.J. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol 1999, 20:725-730.
8. Engemann J.J., Carmeli Y., Cosgrove S.E., Fowler V.G., Bronstein M.Z., Trivette S.L., et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 2003, 36:592-598.
9. Huiras P., Logan J.K., Papadopoulos S., Whitney D. Local antimicrobial administration for prophylaxis of surgical site infections. Pharmacotherapy 2012, 32:1006-1019.
10. Duarte R.M., Vaccaro A.R. Spinal infection: state of the art and management algorithm. Eur Spine J 2013, 22:2787-2799.
11. Mera R.M., Suaya J.A., Amrine-Madsen H., Hogea C.S., Miller L.A., Lu E.P., et al. Increasing role of Staphylococcus aureus and community-acquired methicillin-resistant Staphylococcus aureus infections in the United States: a 10-year trend of replacement and expansion. Microb Drug Resist 2011, 17:321-328.
12. Sweet F.A., Roh M., Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes. Spine 2011, 36:2084-2088. [PhilaPa 1976].
13. Strom R.G., Pacione D., Kalhorn S.P., Frempong-Boadu A.K. Lumbar laminectomy and fusion with routine local application of vancomycin powder: decreased infection rate in instrumented and non-instrumented cases. Clin Neurol Neurosurg 2013, 115:1766-1769.
14. Caroom C., Tullar J.M., Benton E.G., Jones J.R., Chaput C.D. Intrawound vancomycin powder reduces surgical site infections in posterior cervical fusion. Spine 2013, 38:1183-1187. [PhilaPa 1976].
15. Gans I., Dormans J.P., Spiegel D.A., Flynn J.M., Sankar W.N., Campbell R.M., et al. Adjunctive vancomycin powder in pediatric spine surgery is safe. Spine 2013, 38:1703-1707. [PhilaPa 1976].
16. Pahys J.M., Pahys J.R., Cho S.K., Kang M.M., Zebala L.P., Hawasli A.H., et al. Methods to decrease postoperative infections following posterior cervical spine surgery. J Bone Joint Surg Am 2013, 95:549-554.
17. Strom R.G., Pacione D., Kalhorn S.P., Frempong-Boadu A.K. Decreased risk of wound infection after posterior cervical fusion with routine local application of vancomycin powder. Spine 2013, [PhilaPa 1976]. 10.1097/BRS.0b013e318285b219.
18. Godil S.S., Parker S.L., O'Neill K.R., Devin C.J., McGirt M.J. Comparative effectiveness and cost-benefit analysis of local application of vancomycin powder in posterior spinal fusion for spine trauma. J Neurosurg Spine 2013, 19:331-335.
19. Harbord R.M., Egger M., Sterne J.A.C. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 2006, 25:3443-3457.
20. Emohare O., Ledonio C.G., Hill B.W., Davis R., Polly D.W., Kang M. Cost savings analysis of intra-wound vancomycin powder in posterior spinal surgery. Spine J 2014, 10.1016/j.spinee.2014.03.011.
21. Tubaki V.R., Rajasekaran S., Shetty A.P. Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients. Spine 2013, 38:2149-2155. [PhilaPa 1976].
22. Martin J.R., Adogwa O., Brown C.R., Bagley C.A., Richardson W.J., Lad S.P., et al. Experience with intrawound vancomycin powder for spinal deformity surgery. Spine 2014, 39:177-184. [PhilaPa 1976].
23. Chiang H.-Y., Herwaldt L.A., Blevins A.E., Cho E., Schweizer M.L. Effectiveness of local vancomycin powder to decrease surgical site infections: a meta-analysis. Spine J 2014, 14:397-407.