Experience with intrawound vancomycin powder for spinal deformity surgery

Spine

Volumn 39, Issue 2, 2014, Pages 177-184

  Martin, Joel R ^a   Adogwa, Owoicho ^a   Brown, Christopher R ^a   Bagley, Carlos A ^a   Richardson, William J ^a   Lad, Shivanand P ^a   Kuchibhatla, Maragatha ^a   Gottfried, Oren N ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Deformity; Local antibiotics; Posterior lumbar fusion; Spine surgery; Vancomycin powder; Wound infection

Indexed keywords

COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; POWDERS; RETROSPECTIVE STUDIES; SPINAL DISEASES; SURGICAL WOUND INFECTION; TREATMENT OUTCOME; VANCOMYCIN;

EID: 84895071923     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0000000000000071     Document Type: Article

References (22)

1. Pull ter Gunne AF, van Laarhoven CJ, Cohen DB. Surgical site infection after osteotomy of the adult spine: does type of osteotomy matter? Spine J 2010; 10: 410-6.
2. Kirkland KB, Briggs JP, Trivette SL, et al. The impact of surgicalsite infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol 1999; 20: 725-30.
3. Koutsoumbelis S, Hughes AP, Girardi FP, et al. Risk factors for postoperative infection following posterior lumbar instrumented arthrodesis. J Bone Joint Surg Am 2011; 93: 1627-33.
4. Massie JB, Heller JG, Abitbol JJ, et al. Postoperative posterior spinal wound infections. Clin Orthop Relat Res 1992; 99-108.
5. Wimmer C, Gluch H, Franzreb M, et al. Predisposing factors for infection in spine surgery: a survey of 850 spinal procedures. J Spinal Disord 1998; 11: 124-8.
6. Whitehouse JD, Friedman ND, Kirkland KB, et al. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol 2002; 23: 183-9.
7. Klevens RM, Edwards JR, Richards CL, Jr, et al. Estimating health care-Associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007; 122: 160-6.
8. Anderson DJ, Kaye KS, Classen D, et al. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol 2008; 29 ( suppl 1 ): S51-61.
9. Lazar HL, Barlam T, Cabral H. The effect of topical vancomycin applied to sternotomy incisions on postoperative serum vancomycin levels. J Card Surg 2011; 26: 461-5.
10. Mohammed S, Pisimisis GT, Daram SP, et al. Impact of intraoperative administration of local vancomycin on inguinal wound complications. J Vasc Surg 2013; 57: 1079-83.
11. Molinari RW, Khera OA, Molinari WJ. Prophylactic intraoperative powdered vancomycin and postoperative deep spinal wound infection: 1,512 consecutive surgical cases over a 6-year period. Eur Spine J 2012; 21 ( suppl 4 ): S476-82.
12. Ozcan AV, Demir M, Onem G, et al. Topical versus systemic vancomycin for deep sternal wound infection caused by methicillinresistant Staphylococcus aureus in a rodent experimental model. Tex Heart Inst J 2006; 33: 107-10.
13. Strom RG, Pacione D, Kalhorn SP, et al. Decreased risk of wound infection after posterior cervical fusion with routine local application of vancomycin powder. Spine (Phila Pa 1976) 2013.
14. Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: effi-cacy, drug levels, and patient outcomes. Spine (Phila Pa 1976) 2011; 36: 2084-8.
15. Vander Salm TJ, Okike ON, Pasque MK, et al. Reduction of sternal infection by application of topical vancomycin. J Thorac Cardiovasc Surg 1989; 98: 618-22.
16. Caroom C, Tullar JM, Benton EG, Jr, et al. Intrawound vancomycin powder reduces surgical site infections in posterior cervical fusion. Spine (Phila Pa 1976) 2013.
17. O'Neill KR, Smith JG, Abtahi AM, et al. Reduced surgical site infections in patients undergoing posterior spinal stabilization of traumatic injuries using vancomycin powder. Spine J 2011; 11: 641-6.
18. Strom RG, Pacione D, Kalhorn SP, et al. Lumbar laminectomy and fusion with routine local application of vancomycin powder: decreased infection rate in instrumented and non-instrumented cases. Clin Neurol Neurosurg 2013.
19. Klein JD, Hey LA, Yu CS, et al. Perioperative nutrition and postoperative complications in patients undergoing spinal surgery. Spine (Phila Pa 1976) 1996; 21: 2676-82.
20. Olsen MA, Nepple JJ, Riew KD, et al. Risk factors for surgical site infection following orthopaedic spinal operations. J Bone Joint Surg Am 2008; 90: 62-9.
21. Schimmel JJ, Horsting PP, de Kleuver M, et al. Risk factors for deep surgical site infections after spinal fusion. Eur Spine J 2010; 19: 1711-9.
22. Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1999; 20: 250-78; quiz 279-80.