Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: Efficacy, drug levels, and patient outcomes

Spine

Volumn 36, Issue 24, 2011, Pages 2084-2088

  Sweet, Fred A ^a   Roh, Michael ^a   Sliva, Christopher ^a  

^a Rockford Spine Center   (United States)

Author keywords

infection; instrumentation; MRSA; spine; surgery; vancomycin; wound

Indexed keywords

CEFALEXIN; VANCOMYCIN;

ADOLESCENT; ADULT; AGED; ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROPHYLAXIS; PSEUDARTHROSIS; SPINE FUSION; SURGICAL WOUND; THORACOLUMBAR SPINE; WOUND INFECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; FEMALE; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; QUESTIONNAIRES; RETROSPECTIVE STUDIES; SCOLIOSIS; SPINAL FUSION; STAPHYLOCOCCUS AUREUS; SURGICAL WOUND INFECTION; THORACIC VERTEBRAE; TREATMENT OUTCOME; VANCOMYCIN; YOUNG ADULT;

EID: 80455150534     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181ff2cb1     Document Type: Article

References (22)

1. Klevens RM , Edwards JR , Richard CL , et al. Estimating health care associated infections and deaths in U.S. hospitals, 2002 . Public Health Rep 2007 ; 122 : 160-6
2. Klevens RM , Morrison MA , Nadle J , et al. I nvasive methicillinresistant Staphylococcus aureus infections in the United States . JAMA 2007 ; 298 : 1763-70
3. Borkhuu B , Borowski A , Shah SA , et al. Antibiotic-loaded allograft decreases the rate of acute deep wound infection after spinal fusion in cerebral palsy . Spine 2008 ; 33 : 2300-04
4. Massie JB , Heller AG , Abittol JJ , et al. Post operative posterior spinal wound infections . Clin Orthop Relat Res 1992 ; 284 : 99-108
5. Rechtine GR , Bono PL , Cahill D , et al. Postoperative wound infection after instrumentation of thoracic and lumbar fractures . J Orthop Trauma 2001 ; 15 : 566-69 (Pubitemid 33150259)
6. Sponseller PD , LaPorte DM , Hungerford MW , et al. Deep wound infections after neuromuscular scoliosis surgery: a multi-center study of risk factors and treatment outcomes . Spine 200 ; 25 : 2461-66
7. Hodges SD , Humphreys SC , Eck JC , et al. Low postoperative infection rates with instrumented lumbar fusion . South Med J 1998 ; 91 : 1132-36 (Pubitemid 28555475)
8. Pull ter Gunne AF , Cohen DB . Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery . Spine 2009 ; 34 : 1422-28
9. Noskin GA , Rubin RJ , Schentag JJ , et al. National trends in Staphylococcus aureus infection rates: impact on economic burden and mortality over a 6-year period (1998-2003) . Clin Infect Dis 2007 ; 45 : 1132-40 (Pubitemid 47580311)
10. Finkelstein R , Rabino G , Mashia T , et al. Vancomycin versus cephazolin prophylaxis for cardiac surgery in the setting of high prevalence of methicillin-resistant staphylococcal infections . J thoracic Cardiovasc Surg 2002 ; 123 : 326-32 (Pubitemid 34127121)
11. Soriano A , Marco F , Martinex JA , et al. Infl uence of vancomycin minimum inhibitory concentration on the treatment of methicillin- resistant Staphylococcus aureus bactermia . Clin Infect Dis 2008 ; 46 : 193-200 (Pubitemid 351269157)
12. Neoh HM , Hori S , Komatsu M , et al. Impact of reduced vancomycin susceptibility on the therapeutic outcome of MRSA bloodstream infections . Ann Clin Microbiol Antimicrob 2007 ; 6 : 13
13. Moise PA , Smyth DS , El-Fawal N , et al. Microbiological effects of prior vancomycin use in patients with methicillin-resistant Staphylococcusaureus bacteremia . JAntimicrobChemother 2008 ; 61 : 85-90
14. Scharfenberger A , Clark M , Lavole G , et al. Treatment of an infected total hip replacement with the PROSTALAC System. Part 1: Infection resolution . Can J Surg 2007 ; 50 : 24-8
15. Buttaro MA , Gimenez MI , Greco G , et al. High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties . Acta Orthop 2005 ; 76 : 336-40 (Pubitemid 41039348)
16. Buttaro M , Comba F , Piccaluga F . Vancomycin supplemented cancellous bone allografts in hip revision surgery . Clin Orthop Relat Res 2007 ; 461 : 74-80 (Pubitemid 47344097)
17. Sakaguchi H , Marui A , Hirose K , et al. Less invasive and highly effective method for preventing methicillin-resistant Staphylococcus aureus graft infection by local sustained release of vancomycin . J Antimicrob Chemother 2007 ; 61 : 85-90
18. Chen CE , Ko JY , Pan CC . Results of vancomycin impregnated cancellous bone grafting for infected tibial nonunion . Arch Orthop Trauma Surg 2005 ; 125 : 369-75
19. Wu P , Grainger Dw. Drug/device combinations for local drug therapies and infection prophylaxis . Biomaterials 2006 ; 27 : 2450-67 (Pubitemid 41821824)
20. Saski T , Ishibashi Y , Katano H , et al. In vitro elution of vancomycin from calcium phosphate cement . J Arthroplasty 2005 ; 20 : 1055-59 (Pubitemid 41820994)
21. Chilukuri DM , Shah JC . Local delivery of vancomycin for the prophylaxis of device related infections . Pharm Res 2005 ; 22 : 563-72 (Pubitemid 40603254)
22. Calderone RR , Garland DE , Capen DA , et al. Cost of medical care for postoperative spinal infections . Orthop Clin North Am 1996 ; 27 : 171-82 (Pubitemid 26020222)