Capture and intermediate purification of recombinant antibodies with combined precipitation methods

Biochemical Engineering Journal

Volumn 93, Issue , 2015, Pages 200-211

  Sommer, Ralf ^a   Tscheliessnig, Anne ^a   Satzer, Peter ^a   Schulz, Henk ^b   Helk, Bernhard ^b   Jungbauer, Alois ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Downstream processing; Ethanol; Monoclonal antibody; Polyethylene glycol; Precipitation; Purification

Indexed keywords

AFFINITY CHROMATOGRAPHY; ALIPHATIC COMPOUNDS; ETHANOL; MOLECULAR WEIGHT; MONOCLONAL ANTIBODIES; POLYETHYLENE GLYCOLS; POLYETHYLENES; PRECIPITATION (CHEMICAL); REMOVAL; SATURATED FATTY ACIDS;

CAPRYLIC ACID; DOWNSTREAM-PROCESSING; DRUG SUBSTANCES; HIGH MOLECULAR WEIGHT; HOST CELL PROTEIN; PEG PRECIPITATIONS; PRECIPITATION METHODS; RECOMBINANT ANTIBODY;

PURIFICATION;

ALCOHOL; CALCIUM CHLORIDE; CELL PROTEIN; IMMUNOGLOBULIN G; MACROGOL; OCTANOIC ACID; PROTEIN A; RECOMBINANT ANTIBODY;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); DRUG IMPURITY; FEMALE; HOST CELL; MOLECULAR WEIGHT; NONHUMAN; PRECIPITATION; PURIFICATION;

EID: 84909957764     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2014.10.008     Document Type: Article

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