메뉴 건너뛰기




Volumn 11, Issue 7, 2014, Pages 659-668

Personalized medicine in oncology: Ethical implications for the delivery of healthcare

Author keywords

cancer; ethical issues; genomics; personalized medicine; research; social medicine

Indexed keywords

CANCER CENTER; ETHICS; HEALTH CARE DELIVERY; HEALTH CARE SYSTEM; HUMAN; ONCOLOGY; PERSONALIZED MEDICINE; RESOURCE ALLOCATION; REVIEW;

EID: 84909956885     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme.14.53     Document Type: Review
Times cited : (6)

References (38)
  • 1
    • 84867073537 scopus 로고    scopus 로고
    • Building an innovative model for personalized healthcare
    • Teng K, Eng C, Hess CA Building an innovative model for personalized healthcare. Clev. Clin. J. Med. 79 (Suppl. 1), S1-S9 (2012).
    • (2012) Clev. Clin. J. Med. , vol.79 , pp. S1-S9
    • Teng, K.1    Eng, C.2    Hess, C.A.3
  • 2
    • 28544446695 scopus 로고    scopus 로고
    • Biomarkers in cancer staging, prognosis and treatment selection
    • Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosis and treatment selection. Nat. Rev. Cancer 5 (11), 845-856 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.11 , pp. 845-856
    • Ludwig, J.A.1    Weinstein, J.N.2
  • 3
    • 79953218323 scopus 로고    scopus 로고
    • Interpretation of cytogenetic and molecular results in patients treated for CML
    • Vigil CE, Griffiths EA, Wang ES, Wetzler M. Interpretation of cytogenetic and molecular results in patients treated for CML. Blood Rev. 25 (3), 139-146 (2011).
    • (2011) Blood Rev. , vol.25 , Issue.3 , pp. 139-146
    • Vigil, C.E.1    Griffiths, E.A.2    Wang, E.S.3    Wetzler, M.4
  • 5
    • 84886881318 scopus 로고    scopus 로고
    • Benefits, issues, and recommendations for personalized medicine in oncology in Canada
    • Butts C, Kamel-Reid S, Batist G Benefits, issues, and recommendations for personalized medicine in oncology in Canada. Curr. Oncol. 20 (5), e475-e483 (2013).
    • (2013) Curr. Oncol. , vol.20 , Issue.5 , pp. e475-e483
    • Butts, C.1    Kamel-Reid, S.2    Batist, G.3
  • 6
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • Hamburg MA, Collins FS. The path to personalized medicine. N. Engl. J. Med. 363 (4), 301-304 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.4 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 7
    • 77955590529 scopus 로고    scopus 로고
    • Predictive and prognostic molecular markers for cancer medicine
    • Mehta S, Shelling A, Muthukaruppan A Predictive and prognostic molecular markers for cancer medicine. Ther. Adv. Med. Oncol. 2 (2), 125-148 (2010).
    • (2010) Ther. Adv. Med. Oncol. , vol.2 , Issue.2 , pp. 125-148
    • Mehta, S.1    Shelling, A.2    Muthukaruppan, A.3
  • 8
    • 73949124118 scopus 로고    scopus 로고
    • Personalized medicine: Factors influencing reimbursement
    • Meckley LM, Neumann PJ. Personalized medicine: factors influencing reimbursement. Health Policy 94 (2), 91-100 (2010).
    • (2010) Health Policy , vol.94 , Issue.2 , pp. 91-100
    • Meckley, L.M.1    Neumann, P.J.2
  • 9
    • 0034130561 scopus 로고    scopus 로고
    • Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays
    • Brenner S, Johnson M, Bridgham J Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat. Biotechnol. 18 (6), 630-634 (2000).
    • (2000) Nat. Biotechnol. , vol.18 , Issue.6 , pp. 630-634
    • Brenner, S.1    Johnson, M.2    Bridgham, J.3
  • 10
    • 82655184653 scopus 로고    scopus 로고
    • Personalized oncology through integrative high-throughput sequencing: A pilot study
    • Roychowdhury S, Iyer MK, Robinson DR Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci. Transl. Med. 3 (111), 111ra121 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , Issue.111 , pp. 111ra121
    • Roychowdhury, S.1    Iyer, M.K.2    Robinson, D.R.3
  • 11
    • 84859940323 scopus 로고    scopus 로고
    • Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence
    • Nickel GC, Barnholtz-Sloan J, Gould MP Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence. PLoS ONE 7 (4), e35262 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.4 , pp. e35262
    • Nickel, G.C.1    Barnholtz-Sloan, J.2    Gould, M.P.3
  • 12
    • 84860410319 scopus 로고    scopus 로고
    • Pseudotrisomy 13 syndrome: Use of homozygosity mapping to target candidate genes
    • Marquis-Nicholson R, Aftimos S, Ashton F Pseudotrisomy 13 syndrome: use of homozygosity mapping to target candidate genes. Gene 486 (1-2), 37-40 (2011).
    • (2011) Gene , vol.486 , Issue.1-2 , pp. 37-40
    • Marquis-Nicholson, R.1    Aftimos, S.2    Ashton, F.3
  • 13
    • 78649383152 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Taby R, Issa JP. Cancer epigenetics. CA Cancer J. Clin. 60 (6), 376-392 (2010).
    • (2010) CA Cancer J. Clin. , vol.60 , Issue.6 , pp. 376-392
    • Taby, R.1    Issa, J.P.2
  • 14
    • 84872518586 scopus 로고    scopus 로고
    • Leveraging epidemiology and clinical studies of cancer outcomes: Recommendations and opportunities for translational research
    • Elena JW, Travis LB, Simonds NI Leveraging epidemiology and clinical studies of cancer outcomes: recommendations and opportunities for translational research. J. Natl Cancer Inst. 105 (2), 85-94 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , Issue.2 , pp. 85-94
    • Elena, J.W.1    Travis, L.B.2    Simonds, N.I.3
  • 15
    • 84880535720 scopus 로고    scopus 로고
    • ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    • Green RC, Berg JS, Grody WW ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet. Med. 15 (7), 565-574 (2013).
    • (2013) Genet. Med. , vol.15 , Issue.7 , pp. 565-574
    • Green, R.C.1    Berg, J.S.2    Grody, W.W.3
  • 16
    • 84893858656 scopus 로고    scopus 로고
    • Engaging the next generation of healthcare professionals in genomics: Planning for the future
    • Callier SL, Toma I, McCaffrey T, Harralson AF, O'Brien TJ. Engaging the next generation of healthcare professionals in genomics: planning for the future. Pers. Med. 11 (1), 89-98 (2014).
    • (2014) Pers. Med. , vol.11 , Issue.1 , pp. 89-98
    • Callier, S.L.1    Toma, I.2    McCaffrey, T.3    Harralson, A.F.4    O'Brien, T.J.5
  • 17
    • 84909946716 scopus 로고    scopus 로고
    • La pharmacothrapie personnalis̈e et la pharmacogńtique
    • Letarte N, Lavoie A, Sheehan N La pharmacothrapie personnalis̈e et la pharmacogńtique. Pharmactuel 46 (4), 258-268 (2013).
    • (2013) Pharmactuel , vol.46 , Issue.4 , pp. 258-268
    • Letarte, N.1    Lavoie, A.2    Sheehan, N.3
  • 18
    • 84906858239 scopus 로고    scopus 로고
    • Delivering precision medicine in oncology today and in future the promise and challenges of personalised cancer medicine: A position paper by the European Society for Medical Oncology (ESMO)
    • Ciardiello F, Arnold D, Casali PG Delivering precision medicine in oncology today and in future the promise and challenges of personalised cancer medicine: a position paper by the European Society for Medical Oncology (ESMO). Ann. Oncol. 25 (9), 1673-1678 (2014).
    • (2014) Ann. Oncol. , vol.25 , Issue.9 , pp. 1673-1678
    • Ciardiello, F.1    Arnold, D.2    Casali, P.G.3
  • 19
    • 84904269657 scopus 로고    scopus 로고
    • Cancer risk assessment using genetic panel testing: Considerations for clinical application
    • Hiraki S, Rinella E, Schnabel F, Oratz R, Ostrer H. Cancer risk assessment using genetic panel testing: considerations for clinical application. J. Genet. Counsel. 23 (4), 604-617 (2014).
    • (2014) J. Genet. Counsel. , vol.23 , Issue.4 , pp. 604-617
    • Hiraki, S.1    Rinella, E.2    Schnabel, F.3    Oratz, R.4    Ostrer, H.5
  • 20
    • 84861225247 scopus 로고    scopus 로고
    • Informed consent for whole genome sequencing: A qualitative analysis of participant expectations and perceptions of risks, benefits, and harms
    • Tabor HK, Stock J, Brazg T Informed consent for whole genome sequencing: a qualitative analysis of participant expectations and perceptions of risks, benefits, and harms. Am. J. Med. Genet. A 158A (6), 1310-1319 (2012).
    • (2012) Am. J. Med. Genet. A , vol.158 A , Issue.6 , pp. 1310-1319
    • Tabor, H.K.1    Stock, J.2    Brazg, T.3
  • 21
    • 84904255226 scopus 로고    scopus 로고
    • Genetic counselors views and experiences with the clinical integration of genome sequencing
    • Machini K, Douglas J, Braxton A, Tsipis J, Kramer K. Genetic counselors views and experiences with the clinical integration of genome sequencing. J. Genet. Counsel. 23 (4), 496-505 (2014).
    • (2014) J. Genet. Counsel. , vol.23 , Issue.4 , pp. 496-505
    • MacHini, K.1    Douglas, J.2    Braxton, A.3    Tsipis, J.4    Kramer, K.5
  • 22
    • 84892508175 scopus 로고    scopus 로고
    • Integrating genomics into clinical oncology: Ethical and social challenges from proponents of personalized medicine
    • McGowan ML, Settersten RA Jr, Juengst ET, Fishman JR. Integrating genomics into clinical oncology: ethical and social challenges from proponents of personalized medicine. Urol. Oncol. 32 (2), 187-192 (2014).
    • (2014) Urol. Oncol. , vol.32 , Issue.2 , pp. 187-192
    • Mcgowan, M.L.1    Settersten, R.A.2    Juengst, E.T.3    Fishman, J.R.4
  • 23
    • 84892528364 scopus 로고    scopus 로고
    • Just caring: Assessing the ethical and economic costs of personalized medicine
    • Fleck LM. Just caring: assessing the ethical and economic costs of personalized medicine. Urol. Oncol. 32 (2), 202-206 (2014).
    • (2014) Urol. Oncol. , vol.32 , Issue.2 , pp. 202-206
    • Fleck, L.M.1
  • 24
    • 84872489789 scopus 로고    scopus 로고
    • Personalized medicine and access to health care: Potential for inequitable access[quest]
    • McClellan KA, Avard D, Simard J, Knoppers BM. Personalized medicine and access to health care: potential for inequitable access[quest]. Eur. J. Hum. Genet. 21 (2), 143-147 (2013).
    • (2013) Eur. J. Hum. Genet. , vol.21 , Issue.2 , pp. 143-147
    • McClellan, K.A.1    Avard, D.2    Simard, J.3    Knoppers, B.M.4
  • 25
    • 84864649027 scopus 로고    scopus 로고
    • ACMG policy statement: Points to consider in the clinical application of genomic sequencing
    • American College of Medical Genetics Board of Directors
    • American College of Medical Genetics Board of Directors. ACMG policy statement: points to consider in the clinical application of genomic sequencing. Genet. Med. 14, 759-761 (2012).
    • (2012) Genet. Med. , vol.14 , pp. 759-761
  • 26
    • 78149384636 scopus 로고    scopus 로고
    • Experiences of and perspectives on genetic testing for breast/ovarian cancer in and outside of the customary clinical setting
    • Buckmaster AM, Gallagher P. Experiences of and perspectives on genetic testing for breast/ovarian cancer in and outside of the customary clinical setting. Psychol. Health 25 (9), 1041-1059 (2010).
    • (2010) Psychol. Health , vol.25 , Issue.9 , pp. 1041-1059
    • Buckmaster, A.M.1    Gallagher, P.2
  • 27
    • 84909974867 scopus 로고    scopus 로고
    • Committee on Psychosocial Services to Cancer Patients/Families in a Community Setting
    • Institute of Medicine Adler NE, Ann EK (Eds.) National Academies Press, DC, USA
    • Institute of Medicine. Committee on Psychosocial Services to Cancer Patients/Families in a Community Setting. In: Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs. Adler NE, Ann EK (Eds.) National Academies Press, DC, USA, 51-79 (2008).
    • (2008) Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs , pp. 51-79
  • 28
    • 84877095341 scopus 로고    scopus 로고
    • What can be learnt about disease progression in breast cancer dormancy from relapse data?
    • Willis L, Graham TA, Alarćn T, Alison MR, Tomlinson IPM, Page KM. What can be learnt about disease progression in breast cancer dormancy from relapse data? PLoS ONE 8 (5), e62320 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.8 , pp. e62320
    • Willis, L.1    Graham, T.A.2    Alarćn, T.3    Alison, M.R.4    Tomlinson, I.P.M.5    Page, K.M.6
  • 29
    • 84874028404 scopus 로고    scopus 로고
    • Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: Potential for biomarker development
    • Baker A-M, Graham TA, Wright NA. Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development. J. Pathol. 229 (4), 502-514 (2013).
    • (2013) J. Pathol. , vol.229 , Issue.4 , pp. 502-514
    • Baker, A.-M.1    Graham, T.A.2    Wright, N.A.3
  • 31
    • 84862747248 scopus 로고    scopus 로고
    • After the revolution? Ethical and social challenges in personalized genomic medicine
    • Juengst ET, Settersten RA Jr, Fishman JR, McGowan ML. After the revolution? Ethical and social challenges in personalized genomic medicine. Pers. Med. 9 (4), 429-439 (2012).
    • (2012) Pers. Med. , vol.9 , Issue.4 , pp. 429-439
    • Juengst, E.T.1    Settersten, R.A.2    Fishman, J.R.3    McGowan, M.L.4
  • 32
    • 84865442326 scopus 로고    scopus 로고
    • Pharmacogenomics and personalized medicine: Wicked problems, ragged edges and ethical precipices
    • Fleck LM. Pharmacogenomics and personalized medicine: wicked problems, ragged edges and ethical precipices. Nat. Biotechnol. 29 (6), 757-768 (2012).
    • (2012) Nat. Biotechnol. , vol.29 , Issue.6 , pp. 757-768
    • Fleck, L.M.1
  • 35
    • 77951237625 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mutations across race and ethnicity: Distribution and clinical implications
    • Kurian AW. BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications. Curr. Opin. Obstet. Gynecol. 22 (1), 72-78 (2010).
    • (2010) Curr. Opin. Obstet. Gynecol. , vol.22 , Issue.1 , pp. 72-78
    • Kurian, A.W.1
  • 36
    • 84892547340 scopus 로고    scopus 로고
    • Essential elements of personalized medicine
    • Burke W, Brown Trinidad S, Press NA. Essential elements of personalized medicine. Urol. Oncol. 32 (2), 193-197 (2014).
    • (2014) Urol. Oncol. , vol.32 , Issue.2 , pp. 193-197
    • Burke, W.1    Brown Trinidad, S.2    Press, N.A.3
  • 37
    • 84878008751 scopus 로고    scopus 로고
    • Re-focusing the ethical discourse on personalized medicine: A qualitative interview study with stakeholders in the German healthcare system
    • Schleidgen S, Marckmann G. Re-focusing the ethical discourse on personalized medicine: a qualitative interview study with stakeholders in the German healthcare system. BMC Med. Ethics 14, 20 (2013).
    • (2013) BMC Med. Ethics , vol.14 , pp. 20
    • Schleidgen, S.1    Marckmann, G.2
  • 38
    • 84891835786 scopus 로고    scopus 로고
    • Molecular-targeted agents combination therapy for cancer: Developments and potentials
    • Li F, Zhao C, Wang L. Molecular-targeted agents combination therapy for cancer: developments and potentials. Int. J. Cancer 134 (6), 1257-1269 (2014).
    • (2014) Int. J. Cancer , vol.134 , Issue.6 , pp. 1257-1269
    • Li, F.1    Zhao, C.2    Wang, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.