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Volumn 32, Issue 2, 2014, Pages 187-192

Integrating genomics into clinical oncology: Ethical and social challenges from proponents of personalized medicine

Author keywords

Cancer genomics; Ethics; Genomic testing; Personalized medicine; Social implications; Targeted therapies

Indexed keywords

CONFIDENTIALITY; GENOMICS; HUMAN; INFORMED CONSENT; INTERPERSONAL COMMUNICATION; MAJOR CLINICAL STUDY; MOLECULARLY TARGETED THERAPY; MONITORING; PERSONALIZED MEDICINE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

EID: 84892508175     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2013.10.009     Document Type: Review
Times cited : (43)

References (26)
  • 1
    • 84862747248 scopus 로고    scopus 로고
    • After the revolution? Ethical and social challenges in personalized genomic medicine
    • Juengst E.T., Settersten R.A., Fishman J.R., McGowan M.L. After the revolution? Ethical and social challenges in personalized genomic medicine. Pers Med 2012, 9:429-439.
    • (2012) Pers Med , vol.9 , pp. 429-439
    • Juengst, E.T.1    Settersten, R.A.2    Fishman, J.R.3    McGowan, M.L.4
  • 2
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • Hamburg M.A., Collins F.S. The path to personalized medicine. N Engl J Med 2010, 363:301-304.
    • (2010) N Engl J Med , vol.363 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 3
    • 84858243626 scopus 로고    scopus 로고
    • Update on horizon scans of genetic tests currently available for clinical use in cancers
    • Center for Medicare and Medicaid Services
    • Raman G, Wallace B, Patel K, et al. Update on horizon scans of genetic tests currently available for clinical use in cancers. In. Center for Medicare and Medicaid Services; 2011.
    • (2011)
    • Raman, G.1    Wallace, B.2    Patel, K.3
  • 4
    • 77951778977 scopus 로고    scopus 로고
    • Personalized medicine in oncology: the future is now
    • Schilsky R.L. Personalized medicine in oncology: the future is now. Nat Rev Drug Discov 2010, 9:363-366.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 363-366
    • Schilsky, R.L.1
  • 5
    • 84870377686 scopus 로고    scopus 로고
    • Barriers to the use of personalized medicine in breast cancer
    • Weldon C.B., Trosman J.R., Gradishar W.J., et al. Barriers to the use of personalized medicine in breast cancer. J Oncol Pract 2012, 8:e24-e31.
    • (2012) J Oncol Pract , vol.8
    • Weldon, C.B.1    Trosman, J.R.2    Gradishar, W.J.3
  • 6
    • 69449107418 scopus 로고    scopus 로고
    • Postal survey of physicians and laboratories: practices and perceptions of molecular oncology testing
    • Miller F.A., Krueger P., Christensen R.J., et al. Postal survey of physicians and laboratories: practices and perceptions of molecular oncology testing. BMC Health Serv Res 2009, 9:131.
    • (2009) BMC Health Serv Res , vol.9 , pp. 131
    • Miller, F.A.1    Krueger, P.2    Christensen, R.J.3
  • 7
    • 33751111175 scopus 로고    scopus 로고
    • Genetic susceptibility testing for Alzheimer disease: motivation to obtain information and control as precursors to coping with increased risk
    • Gooding H.C., Linnenbringer E.L., Burack J., et al. Genetic susceptibility testing for Alzheimer disease: motivation to obtain information and control as precursors to coping with increased risk. Patient Educ Couns 2006, 64:259-267.
    • (2006) Patient Educ Couns , vol.64 , pp. 259-267
    • Gooding, H.C.1    Linnenbringer, E.L.2    Burack, J.3
  • 8
    • 55549102328 scopus 로고    scopus 로고
    • Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease
    • Cassidy M.R., Roberts J.S., Bird T.D., et al. Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease. Alzheimers Dement 2008, 4:406-413.
    • (2008) Alzheimers Dement , vol.4 , pp. 406-413
    • Cassidy, M.R.1    Roberts, J.S.2    Bird, T.D.3
  • 9
    • 84855846751 scopus 로고    scopus 로고
    • Beyond the patient: the broader impact of genetic discrimination among individuals at risk of Huntington disease
    • Bombard Y., Palin J., Friedman J.M., et al. Beyond the patient: the broader impact of genetic discrimination among individuals at risk of Huntington disease. Am J Med Genet B 2012, 159B:217-226.
    • (2012) Am J Med Genet B , vol.159 B , pp. 217-226
    • Bombard, Y.1    Palin, J.2    Friedman, J.M.3
  • 11
    • 33645996607 scopus 로고    scopus 로고
    • Beyond the qualitative interview: data preparation and transcription
    • McLellan E., MacQueen K.M., Neidig J.L. Beyond the qualitative interview: data preparation and transcription. Field Methods 2003, 15:63-84.
    • (2003) Field Methods , vol.15 , pp. 63-84
    • McLellan, E.1    MacQueen, K.M.2    Neidig, J.L.3
  • 12
    • 33750505977 scopus 로고    scopus 로고
    • Using thematic analysis in psychology
    • Braun V., Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006, 3:77-101.
    • (2006) Qual Res Psychol , vol.3 , pp. 77-101
    • Braun, V.1    Clarke, V.2
  • 13
    • 0042855876 scopus 로고    scopus 로고
    • Ethical, legal, and social implications of genomic medicine
    • Clayton E.W. Ethical, legal, and social implications of genomic medicine. N Engl J Med 2003, 349:562-569.
    • (2003) N Engl J Med , vol.349 , pp. 562-569
    • Clayton, E.W.1
  • 14
    • 0035778782 scopus 로고    scopus 로고
    • Privacy and confidentiality of genetic information: what rules for the new science?
    • Anderlik M.R., Rothstein M.A. Privacy and confidentiality of genetic information: what rules for the new science?. Annu Rev Genomics Hum Genet 2001, 2:401-433.
    • (2001) Annu Rev Genomics Hum Genet , vol.2 , pp. 401-433
    • Anderlik, M.R.1    Rothstein, M.A.2
  • 15
    • 57049151490 scopus 로고    scopus 로고
    • Ethical and legal implications of cancer genetic testing: do physicians have a duty to warn patients' relatives about possible genetic risks?
    • Storm C., Agarwal R., Offit K. Ethical and legal implications of cancer genetic testing: do physicians have a duty to warn patients' relatives about possible genetic risks?. J Oncol Pract 2008, 4:229-230.
    • (2008) J Oncol Pract , vol.4 , pp. 229-230
    • Storm, C.1    Agarwal, R.2    Offit, K.3
  • 16
    • 84880535720 scopus 로고    scopus 로고
    • ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    • Green R.C., Berg J.S., Grody W.W., et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med 2013, 15:565-574.
    • (2013) Genet Med , vol.15 , pp. 565-574
    • Green, R.C.1    Berg, J.S.2    Grody, W.W.3
  • 17
    • 84880482533 scopus 로고    scopus 로고
    • Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology
    • Lolkema M.P., Gadellaa-van Hooijdonk C.G., Bredenoord A.L., et al. Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology. J Clin Oncol 2013, 31:1842-1848.
    • (2013) J Clin Oncol , vol.31 , pp. 1842-1848
    • Lolkema, M.P.1    Gadellaa-van Hooijdonk, C.G.2    Bredenoord, A.L.3
  • 18
    • 79952185587 scopus 로고    scopus 로고
    • Downsizing genomic medicine: approaching the ethical complexity of whole-genome sequencing by starting small
    • Sharp R.R. Downsizing genomic medicine: approaching the ethical complexity of whole-genome sequencing by starting small. Genet Med 2011, 13:191-194.
    • (2011) Genet Med , vol.13 , pp. 191-194
    • Sharp, R.R.1
  • 19
    • 84875939245 scopus 로고    scopus 로고
    • Implementing genomic medicine in the clinic: the future is here
    • Manolio T.A., Chisholm R.L., Ozenberger B., et al. Implementing genomic medicine in the clinic: the future is here. Genet Med 2013, 15:258-267.
    • (2013) Genet Med , vol.15 , pp. 258-267
    • Manolio, T.A.1    Chisholm, R.L.2    Ozenberger, B.3
  • 20
    • 84884587533 scopus 로고    scopus 로고
    • Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process
    • Ayuso C., Millan J.M., Mancheno M., Dal-Re R. Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process. Eur J Hum Genet 2013, 21:1054-1059.
    • (2013) Eur J Hum Genet , vol.21 , pp. 1054-1059
    • Ayuso, C.1    Millan, J.M.2    Mancheno, M.3    Dal-Re, R.4
  • 22
    • 84878932524 scopus 로고    scopus 로고
    • Genetics patients' perspectives on clinical genomic testing
    • McGowan M.L., Glinka A., Highland J., et al. Genetics patients' perspectives on clinical genomic testing. Pers Med 2013, 10:339-347.
    • (2013) Pers Med , vol.10 , pp. 339-347
    • McGowan, M.L.1    Glinka, A.2    Highland, J.3
  • 23
    • 84875488700 scopus 로고    scopus 로고
    • WCVDL. The economics of genomic medicine: insights from the iom roundtable on translating genomic-based research for health
    • Feero W. WCVDL. The economics of genomic medicine: insights from the iom roundtable on translating genomic-based research for health. J Am Med Assoc 2013, 309:1235-1236.
    • (2013) J Am Med Assoc , vol.309 , pp. 1235-1236
    • Feero, W.1
  • 25
    • 84865442326 scopus 로고    scopus 로고
    • Pharmacogenomics and personalized medicine: wicked problems, ragged edges and ethical precipices
    • Fleck L.M. Pharmacogenomics and personalized medicine: wicked problems, ragged edges and ethical precipices. N Biotechnol 2012, 29:757-768.
    • (2012) N Biotechnol , vol.29 , pp. 757-768
    • Fleck, L.M.1
  • 26
    • 84872489789 scopus 로고    scopus 로고
    • Personalized medicine and access to health care: potential for inequitable access?
    • McClellan K.A., Avard D., Simard J., Knoppers B.M. Personalized medicine and access to health care: potential for inequitable access?. Eur J Hum Genet 2013, 21:143-147.
    • (2013) Eur J Hum Genet , vol.21 , pp. 143-147
    • McClellan, K.A.1    Avard, D.2    Simard, J.3    Knoppers, B.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.