3′-Phosphoadenosine 5′-phosphosulfate allosterically regulates sulfotransferase turnover

Biochemistry

Volumn 53, Issue 44, 2014, Pages 6893-6900

  Wang, Ting ^a   Cook, Ian ^a   Leyh, Thomas S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DIMERS; EFFICIENCY; ENZYMES; HISTOLOGY; TISSUE;

ALLOSTERIC REGULATION; CATALYTIC EFFICIENCIES; DYNAMIC RANGE; ENERGETIC COUPLING; MOLECULAR BASIS; PRIMARY AMINES; SMALL MOLECULES; SUBSTRATE AFFINITY;

NUCLEOTIDES;

ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; AMINE; DIMER; HYDROXYL GROUP; NUCLEOTIDE; SULFOTRANSFERASE 1A1; XENOBIOTIC AGENT; ARYL SULFOTRANSFERASE; PROTEIN BINDING; SULT1A1 PROTEIN, HUMAN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME METABOLISM; LIGAND BINDING; NUCLEOTIDE BINDING SITE; PROTEIN BINDING; PROTEIN EXPRESSION; STOICHIOMETRY; SULFATION; CHEMISTRY; ENZYME ACTIVATION; HUMAN; KINETICS;

ALLOSTERIC REGULATION; ARYLSULFOTRANSFERASE; ENZYME ACTIVATION; HUMANS; KINETICS; PHOSPHOADENOSINE PHOSPHOSULFATE; PROTEIN BINDING;

EID: 84909636845     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501120p     Document Type: Article

References (28)

1. Falany, J. L., Macrina, N., and Falany, C. N. (2002) Regulation of MCF-7 breast cancer cell growth by β-estradiol sulfation Breast Cancer Res. Treat. 74, 167-176
2. Falany, J. L. and Falany, C. N. (1996) Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone Endocrinology 137, 1395-1401
3. Steventon, G. B., Heafield, M. T., Waring, R. H., and Williams, A. C. (1989) Xenobiotic metabolism in Parkinson's disease Neurology 39, 883-887
4. Li, L. and Falany, C. N. (2007) Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins J. Cystic Fibrosis 6, 23-30
5. Moore, K. L. (2003) The biology and enzymology of protein tyrosine O-sulfation J. Biol. Chem. 278, 24243-24246
6. Nowell, S. and Falany, C. N. (2006) Pharmacogenetics of human cytosolic sulfotransferases Oncogene 25, 1673-1678
7. Leyh, T. S. (1993) The physical biochemistry and molecular genetics of sulfate activation Crit. Rev. Biochem. Mol. Biol. 28, 515-542
8. Falany, C. N. (1997) Enzymology of human cytosolic sulfotransferases FASEB J. 11, 206-216
9. Visser, T. J. (1994) Role of sulfation in thyroid hormone metabolism Chem.-Biol. Interact. 92, 293-303
10. Robertson, J. F. and Harrison, M. (2004) Fulvestrant: Pharmacokinetics and pharmacology Br. J. Cancer 90 (Suppl. 1) S7-S10
11. Riches, Z., Stanley, E. L., Bloomer, J. C., and Coughtrie, M. W. (2009) Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: The SULT "pie" Drug Metab. Dispos. 37, 2255-2261
12. Cook, I., Wang, T., Falany, C. N., and Leyh, T. S. (2012) A Nucleotide-Gated Molecular Pore Selects Sulfotransferase Substrates Biochemistry 51, 5674-5683
13. Leyh, T. S., Cook, I., and Wang, T. (2013) Structure, dynamics and selectivity in the sulfotransferase family Drug Metab. Rev. 45, 423-430
14. Cook, I., Wang, T., Almo, S. C., Kim, J., Falany, C. N., and Leyh, T. S. (2013) The gate that governs sulfotransferase selectivity Biochemistry 52, 415-424
15. Cook, I., Wang, T., Falany, C. N., and Leyh, T. S. (2013) High Accuracy In-Silico Sulfotransferase Models J. Biol. Chem. 288, 34494-34501
16. Zhang, H., Varlamova, O., Vargas, F. M., Falany, C. N., and Leyh, T. S. (1998) Sulfuryl transfer: The catalytic mechanism of human estrogen sulfotransferase J. Biol. Chem. 273, 10888-10892
17. Sun, M. and Leyh, T. S. (2010) The human estrogen sulfotransferase: A half-site reactive enzyme Biochemistry 49, 4779-4785
18. Johnson, K. (1992) Transient-state kinetic analysis of enzyme reaction pathways. In The Enzymes (Sigman, D. S., Ed.) pp 1-61, Academic Press, New York.
19. Cleland, W. W. (1979) Statistical analysis of enzyme kinetic data Methods Enzymol. 63, 103-138
20. Cook, I., Wang, T., Almo, S. C., Kim, J., Falany, C. N., and Leyh, T. S. (2013) Testing the Sulfotransferase Molecular Pore Hypothesis J. Biol. Chem. 288, 8619-8626
21. Wang, T., Cook, I., Falany, C. N., and Leyh, T. S. (2014) Paradigms of Sulfotransferase Catalysis: The Mechanism of SULT2A1 J. Biol. Chem. 289, 26474-26480
22. Tyapochkin, E., Cook, P. F., and Chen, G. (2008) Isotope exchange at equilibrium indicates a steady state ordered kinetic mechanism for human sulfotransferase Biochemistry 47, 11894-11899
23. Whittemore, R. M., Pearce, L. B., and Roth, J. A. (1986) Purification and kinetic characterization of a phenol-sulfating form of phenol sulfotransferase from human brain Arch. Biochem. Biophys. 249, 464-471
24. Brzeznicka, E. A., Hazelton, G. A., and Klaassen, C. D. (1987) Comparison of adenosine 3′-phosphate 5′-phosphosulfate concentrations in tissues from different laboratory animals Drug Metab. Dispos. 15, 133-135
25. Cappiello, M., Franchi, M., Giuliani, L., and Pacifici, G. M. (1989) Distribution of 2-naphthol sulphotransferase and its endogenous substrate adenosine 3′-phosphate 5′-phosphosulphate in human tissues Eur. J. Clin. Pharmacol. 37, 317-320
26. Pacifici, G. M., Franchi, M., Colizzi, C., Giuliani, L., and Rane, A. (1988) Sulfotransferase in humans: Development and tissue distribution Pharmacology 36, 411-419
27. Sakakibara, Y., Yanagisawa, K., Katafuchi, J., Ringer, D. P., Takami, Y., Nakayama, T., Suiko, M., and Liu, M. C. (1998) Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene J. Biol. Chem. 273, 33929-33935
28. McIntosh, R. L. and Anderson, V. (2010) A Comprehensive Tissue Properties Database Provided for the Thermal Assessment of a Human at Rest Biophys. Rev. Lett. 5, 129