CTR2 identifies a population of cancer cells with stem cell-like features in patients with clear cell renal cell carcinoma

Journal of Urology

Volumn 192, Issue 6, 2014, Pages 1831-1841

  Galleggiante, Vanessa ^a   Rutigliano, Monica ^a   Sallustio, Fabio ^a   Ribatti, Domenico ^a   Ditonno, Pasquale ^a   Bettocchi, Carlo ^a   Selvaggi, Francesco Paolo ^a   Lucarelli, Giuseppe ^a   Battaglia, Michele ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

AC133 antigen; antigens; carcinoma; CD24; CTR2 protein; human; kidney; renal cell

Indexed keywords

5' NUCLEOTIDASE; ALPHA FETOPROTEIN; CD133 ANTIGEN; CD14 ANTIGEN; CD20 ANTIGEN; CD24 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CELL MEMBRANE MARKER; CHORIONIC GONADOTROPIN; ENDOGLIN; GOOSECOID PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; MEMBRANE PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN CTR2; THY 1 ANTIGEN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN RECEPTOR 2; CATION TRANSPORT PROTEIN; SLC31A2 PROTEIN, HUMAN;

ADIPOCYTE; ADULT; ADULT STEM CELL; ANGIOGENESIS; ARTICLE; CANCER STEM CELL; CARCINOGENICITY; CELL CLONE; CELL CLONING; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL RENEWAL; CELL VACUOLE; CHORIOALLANTOIS; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MALE; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; OSTEOBLAST; PHENOTYPE; PROTEIN EXPRESSION; PROTEOMICS; RENAL CELL CARCINOMA CELL LINE; CHEMISTRY; KIDNEY TUMOR; MIDDLE AGED; PATHOLOGY; TUMOR CELL CULTURE;

CARCINOMA, RENAL CELL; CATION TRANSPORT PROTEINS; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; TUMOR CELLS, CULTURED;

EID: 84909627964     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.06.070     Document Type: Article

References (30)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics CA Cancer J Clin 63 2013 11
2. J.E. Dick Stem cell concepts renew cancer research Blood 112 2008 4793
3. P.C. Hermann, S.L. Huber, and T. Herrler Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Cell Stem Cell 1 2007 313
4. S.K. Singh, I.D. Clarke, and M. Terasaki Identification of a cancer stem cell in human brain tumors Cancer Res 63 2003 5821
5. F. Sallustio, V. Costantino, and S.N. Cox Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvesicle-shuttled decorin Kidney Int 83 2013 392
6. P. Romagnani, and G. Remuzzi CD133+ renal stem cells always co-express CD24 in adult human kidney tissue Stem Cell Res 12 2014 828
7. F. Sallustio, L. De Benedictis, and G. Castellano TRL2 plays a role in activation of human resident renal/progenitor cells FASEB J 24 2010 514
8. D. Ribatti, B. Nico, and A. Vacca The gelatin sponge-chorioallantoic membrane assay Nature Protoc 1 2006 85
9. F.L. Gu, S.L. Cai, and B.J. Cai Cellular origin of renal cell carcinoma an immunohistological study on monoclonal antibodies Scand J Urol Nephrol Suppl 138 1991 203
10. G. Kovacs Molecular differential pathology of renal cell tumours Histopathology 22 1993 1
11. M.L. Angelotti, E. Ronconi, and L. Ballerini Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury Stem Cells 30 2012 1714
12. D. Lindgren, A.K. Boström, and K. Nilsson Isolation and characterization of progenitor-like cells from human renal proximal tubules Am J Pathol 178 2011 828
13. P. Romagnani, and H.J. Anders What can tubular progenitor cultures teach us about kidney regeneration? Kidney Int 83 2013 351
14. E. Ronconi, C. Sagrinati, and M.L. Angelotti Regeneration of glomerular podocytes by human renal progenitors J Am Soc Nephrol 20 2009 322
15. C. Sagrinati, G.S. Netti, and B. Mazzinghi Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys J Am Soc Nephrol 17 2006 2443
16. D. Fang, T.K. Nguyen, and K. Leishear A tumorigenic subpopulation with stem cell properties in melanomas Cancer Res 65 2005 9328
17. L. Ricci-Vitiani, D.G. Lombardi, and E. Pilozzi Identification and expansion of human colon-cancer-initiating cells Nature 445 2007 111
18. S.A. Bapat, A.M. Mali, and C.B. Koppikar Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer Cancer Research 65 2005 3025
19. A.H. Yin, S. Miraglia, and E.D. Zanjani AC133, a novel marker for human hematopoietic stem and progenitor cells Blood 90 1997 5002
20. N. Uchida, D.W. Buck, and D. He Direct isolation of human central nervous system stem cells Proc Natl Acad Sci U S A 97 2000 14720
21. C.A. O'Brien, A. Pollett, and S. Gallinger A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Nature 445 2007 106
22. S.K. Singh, C. Hawkins, and I.D. Clarke Identification of human brain tumour initiating cells Nature 432 2004 396
23. S. Bruno, B. Bussolati, and C. Grange CD133+ renal progenitor cells contribute to tumor angiogenesis Am J Pathol 169 2006 2223
24. B. Bussolati, S. Bruno, and C. Grange Identification of a tumor-initiating stem cell population in human renal carcinomas FASEB J 22 2008 3696
25. B. Bussolati, B. Dekel, and B. Azzarone Human renal cancer stem cells Cancer Lett 338 2013 141
26. E.M. Rees, J. Lee, and D.J. Thiele Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter J Biol Chem 279 2004 54221
27. J. Bertinato, E. Swist, and L.J. Plouffe Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells Biochem J 409 2008 731
28. P.V. van den Berghe, D.E. Folmer, and H.E. Malingré Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake Biochem J 407 2007 49
29. B.G. Blair, C.A. Larson, and P.L. Adams Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo Mol Pharmacol 79 2011 157
30. Y.Y. Lee, C.H. Choi, and I.G. Do Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy Gynecol Oncol 122 2011 361