A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka

Aquatic Toxicology

Volumn 158, Issue , 2015, Pages 14-21

  Saunders, David M V ^a   Podaima, Michelle ^a   Codling, Garry ^a   Giesy, John P ^a,b,c,d,e   Wiseman, Steve ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e NANJING UNIVERSITY   (China)

Author keywords

Endocrine disruption; Firemaster 550; Novel brominated flame retardants; Reproduction

Indexed keywords

2 ETHYLHEXYL 2,3,4,5 TETRABROMOBENZOIC ACID; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; BIS(2 ETHYLHEXYL) 2,3,4,5 TETRABROMOPHTHALATE; CYTOCHROME P450 17; CYTOCHROME P450 3A; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GONADORELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INHIBIN A; LUTEINIZING HORMONE BETA SUBUNIT; LUTEINIZING HORMONE RECEPTOR; NEUROPEPTIDE Y; ORGANOBROMINE DERIVATIVE; UNCLASSIFIED DRUG; VITELLOGENIN; FLAME RETARDANT; WATER POLLUTANT;

ABUNDANCE; ANDROGEN; CHEMICAL POLLUTANT; ENDOCRINE DISRUPTOR; ESTROGENIC COMPOUND; FECUNDITY; FINFISH; SEX HORMONE;

20 BETA HSD GENE; 3 BETA HSD GENE; ACTIVIN BA GENE; ACTIVIN BB GENE; ANIMAL EXPERIMENT; ANNEXIN MAX2 GENE; AR ALPHA GENE; ARTICLE; CHG H GENE; CHG HM GENE; CHG L GENE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYP11A GENE; CYP17 GENE; CYP19A GENE; CYP19B GENE; CYP3A GENE; DOWN REGULATION; EGG PRODUCTION; ENDOCRINE FUNCTION; ER ALPHA GENE; ER BETA GENE; FEMALE; FERTILITY; FSHR GENE; GENE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENETIC TRANSCRIPTION; GNRH II GENE; GNRH RI GENE; GNRH RII GENE; GNRH RIII GENE; GTHA GENE; HDLR GENE; HMGR GENE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS PITUITARY GONAD LIVER AXIS; IN VITRO STUDY; INHIBIN A GENE; LDLR GENE; LH BETA GENE; LHR GENE; MALE; NEUROPEP Y GENE; NONHUMAN; ORYZIAS LATIPES; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTIVE TOXICITY; STAR GENE; STEROIDOGENESIS; TOXICITY TESTING; VTG I GENE; VTG II GENE; ANIMAL; DRUG EFFECTS; ENDOCRINE SYSTEM; GENE EXPRESSION PROFILING; GENETICS; GONAD; HYPOPHYSIS; HYPOTHALAMUS; LIVER; METABOLISM; ORYZIAS; PHYSIOLOGY; TOXICITY; WATER POLLUTANT;

ORYZIAS LATIPES;

ANIMALS; ENDOCRINE SYSTEM; FEMALE; FERTILITY; FLAME RETARDANTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GONADS; HYPOTHALAMUS; LIVER; MALE; ORYZIAS; PITUITARY GLAND; WATER POLLUTANTS, CHEMICAL;

EID: 84909608120     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2014.10.019     Document Type: Article

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