-
1
-
-
33646140851
-
Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
-
Aggarwal D, Fernandez ML, Soliman GA. 2006. Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metab Clin Exp 55:794-802.
-
(2006)
Metab Clin Exp
, vol.55
, pp. 794-802
-
-
Aggarwal, D.1
Fernandez, M.L.2
Soliman, G.A.3
-
2
-
-
77949837737
-
Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist
-
Baraboi ED, Smith P, Ferguson AV, Richard D. 2010. Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist. Am J Physiol Regul Integr Comp Physiol 298:R1098-1110.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.298
, pp. R1098-R1110
-
-
Baraboi, E.D.1
Smith, P.2
Ferguson, A.V.3
Richard, D.4
-
3
-
-
56449115916
-
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
-
Blouet C, Ono H, Schwartz GJ. 2008. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab 8:459-467.
-
(2008)
Cell Metab
, vol.8
, pp. 459-467
-
-
Blouet, C.1
Ono, H.2
Schwartz, G.J.3
-
4
-
-
84873162774
-
Hypothalamic tanycytes: potential roles in the control of feeding and energy balance
-
Bolborea M, Dale N. 2013. Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends Neurosci 36:91-100.
-
(2013)
Trends Neurosci
, vol.36
, pp. 91-100
-
-
Bolborea, M.1
Dale, N.2
-
5
-
-
84893202143
-
MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1
-
in press
-
Brundage ME, Tandon P, Eaves DW, Williams JP, Miller SJ, Hennigan RH, Jegga A, Cripe TP, Ratner N. 2014. MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1. Oncogene, in press.
-
(2014)
Oncogene
-
-
Brundage, M.E.1
Tandon, P.2
Eaves, D.W.3
Williams, J.P.4
Miller, S.J.5
Hennigan, R.H.6
Jegga, A.7
Cripe, T.P.8
Ratner, N.9
-
6
-
-
84878819433
-
Revisiting the ventral medial nucleus of the hypothalamus: the roles of SF-1 neurons in energy homeostasis
-
Choi YH, Fujikawa T, Lee J, Reuter A, Kim KW. 2013. Revisiting the ventral medial nucleus of the hypothalamus: the roles of SF-1 neurons in energy homeostasis. Front Neurosci 7:71.
-
(2013)
Front Neurosci
, vol.7
, pp. 71
-
-
Choi, Y.H.1
Fujikawa, T.2
Lee, J.3
Reuter, A.4
Kim, K.W.5
-
7
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. 2006. Hypothalamic mTOR signaling regulates food intake. Science 312:927-930.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
8
-
-
2642573308
-
Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
-
de Bilbao F, Arsenijevic D, Vallet P, Hjelle OP, Ottersen OP, Bouras C, Raffin Y, Abou K, Langhans W, Collins S, Plamondon J, Alves-Guerra MC, Haguenauer A, Garcia I, Richard D, Ricquier D, Giannakopoulos P. 2004. Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J Neurochem 89:1283-1292.
-
(2004)
J Neurochem
, vol.89
, pp. 1283-1292
-
-
de Bilbao, F.1
Arsenijevic, D.2
Vallet, P.3
Hjelle, O.P.4
Ottersen, O.P.5
Bouras, C.6
Raffin, Y.7
Abou, K.8
Langhans, W.9
Collins, S.10
Plamondon, J.11
Alves-Guerra, M.C.12
Haguenauer, A.13
Garcia, I.14
Richard, D.15
Ricquier, D.16
Giannakopoulos, P.17
-
9
-
-
84871714173
-
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
-
Fernandez-Saiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, Kurutz J, Peschel C, Pagano M, Kuster B, Bassermann F. 2013. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol 15:72-81.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 72-81
-
-
Fernandez-Saiz, V.1
Targosz, B.S.2
Lemeer, S.3
Eichner, R.4
Langer, C.5
Bullinger, L.6
Reiter, C.7
Slotta-Huspenina, J.8
Schroeder, S.9
Knorn, A.M.10
Kurutz, J.11
Peschel, C.12
Pagano, M.13
Kuster, B.14
Bassermann, F.15
-
10
-
-
42449104351
-
mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
-
Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G. 2008. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57:945-957.
-
(2008)
Diabetes
, vol.57
, pp. 945-957
-
-
Fraenkel, M.1
Ketzinel-Gilad, M.2
Ariav, Y.3
Pappo, O.4
Karaca, M.5
Castel, J.6
Berthault, M.F.7
Magnan, C.8
Cerasi, E.9
Kaiser, N.10
Leibowitz, G.11
-
11
-
-
34347358488
-
The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior
-
Fry M, Ferguson AV. 2007. The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior. Physiol Behav 91:413-423.
-
(2007)
Physiol Behav
, vol.91
, pp. 413-423
-
-
Fry, M.1
Ferguson, A.V.2
-
12
-
-
0035803984
-
Central neurocircuitry associated with emesis
-
Hornby PJ. 2001. Central neurocircuitry associated with emesis. Am J Med 111(suppl 8A):106S-112S.
-
(2001)
Am J Med
, vol.111
, Issue.8
, pp. 106S-112S
-
-
Hornby, P.J.1
-
13
-
-
77953218866
-
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
-
Houde VP, Brule S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, Marette A. 2010. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59:1338-1348.
-
(2010)
Diabetes
, vol.59
, pp. 1338-1348
-
-
Houde, V.P.1
Brule, S.2
Festuccia, W.T.3
Blanchard, P.G.4
Bellmann, K.5
Deshaies, Y.6
Marette, A.7
-
14
-
-
84872527628
-
mTOR is a key modulator of ageing and age-related disease
-
Johnson SC, Rabinovitch PS, Kaeberlein M. 2013. mTOR is a key modulator of ageing and age-related disease. Nature 493:338-345.
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
15
-
-
84902329648
-
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
-
Kocalis HE, Hagan SL, George L, Turney MK, Siuta MA, Laryea GN, Morris LC, Muglia LJ, Printz RL, Stanwood GD, Niswender KD. 2014. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab 3:394-407.
-
(2014)
Mol Metab
, vol.3
, pp. 394-407
-
-
Kocalis, H.E.1
Hagan, S.L.2
George, L.3
Turney, M.K.4
Siuta, M.A.5
Laryea, G.N.6
Morris, L.C.7
Muglia, L.J.8
Printz, R.L.9
Stanwood, G.D.10
Niswender, K.D.11
-
16
-
-
84869882415
-
Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding
-
Kohno D, Yada T. 2012. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding. Neuropeptides 46:315-319.
-
(2012)
Neuropeptides
, vol.46
, pp. 315-319
-
-
Kohno, D.1
Yada, T.2
-
17
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante M, Sabatini DM. 2009. mTOR signaling at a glance. J Cell Sci 122:3589-3594.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
18
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
19
-
-
84864692282
-
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity
-
Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. 2012. DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metab 16:202-212.
-
(2012)
Cell Metab
, vol.16
, pp. 202-212
-
-
Laplante, M.1
Horvat, S.2
Festuccia, W.T.3
Birsoy, K.4
Prevorsek, Z.5
Efeyan, A.6
Sabatini, D.M.7
-
20
-
-
84899094563
-
The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity
-
Meng ZX, Wang L, Xiao Y, Lin JD. 2014. The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity. Diabetes 63:1533-1545.
-
(2014)
Diabetes
, vol.63
, pp. 1533-1545
-
-
Meng, Z.X.1
Wang, L.2
Xiao, Y.3
Lin, J.D.4
-
21
-
-
84887184185
-
Circumventricular organs: targets for integration of circulating fluid and energy balance signals?
-
Mimee A, Smith PM, Ferguson AV. 2013. Circumventricular organs: targets for integration of circulating fluid and energy balance signals? Physiol Behav 121:96-102.
-
(2013)
Physiol Behav
, vol.121
, pp. 96-102
-
-
Mimee, A.1
Smith, P.M.2
Ferguson, A.V.3
-
22
-
-
0021590910
-
Area postrema and adjacent solitary nucleus in water and energy balance
-
Miselis RR, Hyde TM, Shapiro RE. 1984. Area postrema and adjacent solitary nucleus in water and energy balance. Fed Proc 43:2969-2971.
-
(1984)
Fed Proc
, vol.43
, pp. 2969-2971
-
-
Miselis, R.R.1
Hyde, T.M.2
Shapiro, R.E.3
-
23
-
-
63449109316
-
Critical role for hypothalamic mTOR activity in energy balance
-
Mori H, Inoki K, Munzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Jr., Guan KL. 2009. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab 9:362-374.
-
(2009)
Cell Metab
, vol.9
, pp. 362-374
-
-
Mori, H.1
Inoki, K.2
Munzberg, H.3
Opland, D.4
Faouzi, M.5
Villanueva, E.C.6
Ikenoue, T.7
Kwiatkowski, D.8
MacDougald, O.A.9
Myers Jr, M.G.10
Guan, K.L.11
-
24
-
-
33748931457
-
Central nervous system control of food intake and body weight
-
Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW. 2006. Central nervous system control of food intake and body weight. Nature 443:289-295.
-
(2006)
Nature
, vol.443
, pp. 289-295
-
-
Morton, G.J.1
Cummings, D.E.2
Baskin, D.G.3
Barsh, G.S.4
Schwartz, M.W.5
-
25
-
-
84055213663
-
Adult hippocampal neurogenesis and its role in Alzheimer's disease
-
Mu Y, Gage FH. 2011. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegen 6:85.
-
(2011)
Mol Neurodegen
, vol.6
, pp. 85
-
-
Mu, Y.1
Gage, F.H.2
-
26
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. 2009. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137:873-886.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
27
-
-
40449138261
-
The area postrema: a brain monitor and integrator of systemic autonomic state
-
Price CJ, Hoyda TD, Ferguson AV. 2008. The area postrema: a brain monitor and integrator of systemic autonomic state. Neuroscientist 14:182-194.
-
(2008)
Neuroscientist
, vol.14
, pp. 182-194
-
-
Price, C.J.1
Hoyda, T.D.2
Ferguson, A.V.3
-
28
-
-
40949150324
-
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
-
Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB. 2008. A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57:594-605.
-
(2008)
Diabetes
, vol.57
, pp. 594-605
-
-
Ropelle, E.R.1
Pauli, J.R.2
Fernandes, M.F.3
Rocco, S.A.4
Marin, R.M.5
Morari, J.6
Souza, K.K.7
Dias, M.M.8
Gomes-Marcondes, M.C.9
Gontijo, J.A.10
Franchini, K.G.11
Velloso, L.A.12
Saad, M.J.13
Carvalheira, J.B.14
-
29
-
-
79959612285
-
Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats
-
Roy C, Roy MC, Gauvreau D, Poulin AM, Tom FQ, Timofeeva E, Richard D, Cianflone K. 2011. Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats. Am J Physiol Endocrinol Metab 301:E232-241.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
, pp. E232-E241
-
-
Roy, C.1
Roy, M.C.2
Gauvreau, D.3
Poulin, A.M.4
Tom, F.Q.5
Timofeeva, E.6
Richard, D.7
Cianflone, K.8
-
30
-
-
57649227693
-
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
-
Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. 2009. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ 16:46-56.
-
(2009)
Cell Death Differ
, vol.16
, pp. 46-56
-
-
Sarkar, S.1
Ravikumar, B.2
Floto, R.A.3
Rubinsztein, D.C.4
-
31
-
-
0024463970
-
A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes
-
Simmons DM, Arriza JL, Swanson LW. 1989. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J Histotechnol 12:169-181.
-
(1989)
J Histotechnol
, vol.12
, pp. 169-181
-
-
Simmons, D.M.1
Arriza, J.L.2
Swanson, L.W.3
-
32
-
-
77955487852
-
Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ
-
Smith PM, Ferguson AV. 2010. Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ. Am J Physiol Regul Integr Comp Physiol 299:R405-415.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.299
, pp. R405-R415
-
-
Smith, P.M.1
Ferguson, A.V.2
-
33
-
-
80052758119
-
Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning
-
Spencer CM, Eckel LA, Nardos R, Houpt TA. 2012. Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning. Physiol Behav 105:151-160.
-
(2012)
Physiol Behav
, vol.105
, pp. 151-160
-
-
Spencer, C.M.1
Eckel, L.A.2
Nardos, R.3
Houpt, T.A.4
-
34
-
-
65549150407
-
Management of side effects of sirolimus therapy
-
Stallone G, Infante B, Grandaliano G, Gesualdo L. 2009. Management of side effects of sirolimus therapy. Transplantation 87(suppl 8):S23-26.
-
(2009)
Transplantation
, vol.87
, Issue.8 SUPPL
, pp. S23-S26
-
-
Stallone, G.1
Infante, B.2
Grandaliano, G.3
Gesualdo, L.4
-
35
-
-
84904489272
-
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
-
Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. 2014. GABAergic and glutamatergic efferents of the mouse ventral tegmental area. J Comp Neurol 522:3308-3334.
-
(2014)
J Comp Neurol
, vol.522
, pp. 3308-3334
-
-
Taylor, S.R.1
Badurek, S.2
Dileone, R.J.3
Nashmi, R.4
Minichiello, L.5
Picciotto, M.R.6
-
36
-
-
70349315117
-
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
-
Villanueva EC, Munzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG, Jr. 2009. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 150:4541-4551.
-
(2009)
Endocrinology
, vol.150
, pp. 4541-4551
-
-
Villanueva, E.C.1
Munzberg, H.2
Cota, D.3
Leshan, R.L.4
Kopp, K.5
Ishida-Takahashi, R.6
Jones, J.C.7
Fingar, D.C.8
Seeley, R.J.9
Myers Jr, M.G.10
-
37
-
-
84891926336
-
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity
-
Volkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA. 2014. PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. EMBO Mol Med 6:57-65.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 57-65
-
-
Volkers, M.1
Doroudgar, S.2
Nguyen, N.3
Konstandin, M.H.4
Quijada, P.5
Din, S.6
Ornelas, L.7
Thuerauf, D.J.8
Gude, N.9
Friedrich, K.10
Herzig, S.11
Glembotski, C.C.12
Sussman, M.A.13
-
38
-
-
84881228970
-
Distinct glutamatergic and GABAergic subsets of hypothalamic pro-opiomelanocortin neurons revealed by in situ hybridization in male rats and mice
-
Wittmann G, Hrabovszky E, Lechan RM. 2013. Distinct glutamatergic and GABAergic subsets of hypothalamic pro-opiomelanocortin neurons revealed by in situ hybridization in male rats and mice. J Comp Neurol 521:3287-3302.
-
(2013)
J Comp Neurol
, vol.521
, pp. 3287-3302
-
-
Wittmann, G.1
Hrabovszky, E.2
Lechan, R.M.3
-
39
-
-
79959669929
-
Cajal revisited: does the VMH make us fat?
-
Yi CX, Scherer T, Tschop MH. 2011. Cajal revisited: does the VMH make us fat? Nat Neurosci 14:806-808.
-
(2011)
Nat Neurosci
, vol.14
, pp. 806-808
-
-
Yi, C.X.1
Scherer, T.2
Tschop, M.H.3
-
40
-
-
84888054247
-
Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1
-
Zhang W, Zhang C, Fritze D, Chai B, Li J, Mulholland MW. 2013. Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1. Exp Physiol 98:1696-1704.
-
(2013)
Exp Physiol
, vol.98
, pp. 1696-1704
-
-
Zhang, W.1
Zhang, C.2
Fritze, D.3
Chai, B.4
Li, J.5
Mulholland, M.W.6
|