The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology

Biochemistry

Volumn 53, Issue 44, 2014, Pages 6968-6980

  Andreasen, Maria ^a,b   Skeby, Katrine Kirkeby ^b   Zhang, Shuai ^a   Nielsen, Erik Holm ^a,b   Klausen, Lasse Hyldgaard ^a   Frahm, Heidi ^a,b   Christiansen, Gunna ^a   Skrydstrup, Troels ^a,b   Dong, Mingdong ^a   Schiøtt, Birgit ^b   Otzen, Daniel ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONES; MOLECULAR DYNAMICS; MORPHOLOGY;

AGGREGATION PROPENSITY; AMYLOIDOGENIC PEPTIDES; FIBRIL MORPHOLOGY; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR INSIGHTS; PEPTIDE FRAGMENTS; SEQUENCE-DEPENDENT; TERMINAL MODIFICATIONS;

PEPTIDES;

ACETIC ACID DERIVATIVE; AMYLIN; AMYLOID PROTEIN; HYDROGEN; PEPTIDE FRAGMENT; PEPTIDE HORMONE; AMYLOID;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CAPPING PHENOMENON; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FIBER; HYDROGEN BOND; HYDROPHOBICITY; IN VIVO STUDY; KINETICS; MOLECULAR DYNAMICS; MORPHOLOGY; PEPTIDE SYNTHESIS; PROTEIN ACETYLATION; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMISTRY; HUMAN; PROTEIN PROCESSING; PROTEINOSIS;

AMINO ACID SEQUENCE; AMYLOID; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISLET AMYLOID POLYPEPTIDE; KINETICS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY;

EID: 84909594820     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500674u     Document Type: Article

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