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Volumn 395, Issue 10, 2014, Pages 1187-1193

Immune-modulating effects of alpha-1 antitrypsin

Author keywords

Apoptosis; Autoimmunity; Diabetes; Inflammation; Protease; Transplantation

Indexed keywords

ALPHA 1 ANTITRYPSIN; IMMUNOLOGIC FACTOR;

EID: 84908877404     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2014-0161     Document Type: Conference Paper
Times cited : (91)

References (46)
  • 2
    • 84892546029 scopus 로고    scopus 로고
    • The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity
    • Bergin, D.A., Reeves, E.P., Hurley, K., Wolfe, R., Jameel, R., Fitzgerald, S., and McElvaney, N.G. (2014). The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity. Sci. Transl. Med. 6, 217ra1.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 217ra1
    • Bergin, D.A.1    Reeves, E.P.2    Hurley, K.3    Wolfe, R.4    Jameel, R.5    Fitzgerald, S.6    McElvaney, N.G.7
  • 3
    • 0026602386 scopus 로고
    • Inhibition of neutrophil superoxide production by human plasma α1-antitrypsin
    • Bucurenci, N., Blake, D.R., Chidwick, K., and Winyard, P.G. (1992). Inhibition of neutrophil superoxide production by human plasma α1-antitrypsin. FEBS 300, 21-24.
    • (1992) FEBS , vol.300 , pp. 21-24
    • Bucurenci, N.1    Blake, D.R.2    Chidwick, K.3    Winyard, P.G.4
  • 4
    • 0034883830 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    • Churg, A., Dai, J., Zay, K., Karsan, A., Hendricks, R., Yee, C., Martin, R., MacKenzie, R., Xie, C., Zhang, L., et al. (2001). Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab. Invest. 81, 1119-1131.
    • (2001) Lab. Invest. , vol.81 , pp. 1119-1131
    • Churg, A.1    Dai, J.2    Zay, K.3    Karsan, A.4    Hendricks, R.5    Yee, C.6    Martin, R.7    MacKenzie, R.8    Xie, C.9    Zhang, L.10
  • 5
    • 0025350658 scopus 로고
    • α-1 Antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy
    • Crystal, R.G. (1990). α-1 Antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J. Clin. Invest. 85, 1343-1352.
    • (1990) J. Clin. Invest. , vol.85 , pp. 1343-1352
    • Crystal, R.G.1
  • 6
    • 0034687111 scopus 로고    scopus 로고
    • Functional protection by acute phase proteins α1-acid glycoprotein and α1-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation
    • Daemen, M.A.R.C., Heemskerk, V.H., van't Veer, C., Denecker, G., Wolfs, T.G.A.M., Vandenabeele, P., and Buurman, W.A. (2000). Functional protection by acute phase proteins α1-acid glycoprotein and α1-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. Circulation 102, 1420-1426.
    • (2000) Circulation , vol.102 , pp. 1420-1426
    • Daemen, M.A.R.C.1    Heemskerk, V.H.2    Van'T Veer, C.3    Denecker, G.4    Wolfs, T.G.A.M.5    Vandenabeele, P.6    Buurman, W.A.7
  • 7
    • 84879517841 scopus 로고    scopus 로고
    • Immune-directed therapy for type 1 diabetes at the clinical level: The Immune Tolerance Network (ITN) experience
    • Ehlers, M.R. and Nepom, G.T. (2012). Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience. Rev. Diabet. Stud. 9, 359-371.
    • (2012) Rev. Diabet. Stud. , vol.9 , pp. 359-371
    • Ehlers, M.R.1    Nepom, G.T.2
  • 8
    • 17744409446 scopus 로고    scopus 로고
    • Wild-type α1- antitrypsin is in the canonical inhibitory conformation
    • Elliott, P.R., Abrahams, J.P., and Lomas, D.A. (1998). Wild-type α1- antitrypsin is in the canonical inhibitory conformation. J. Mol. Med. 275, 419-425.
    • (1998) J. Mol. Med. , vol.275 , pp. 419-425
    • Elliott, P.R.1    Abrahams, J.P.2    Lomas, D.A.3
  • 11
    • 0024423930 scopus 로고
    • Implications of the three-dimensional structure of α1-antitrypsin for structure and function of serpins
    • Huber, R. and Carrell, R.W. (1989). Implications of the three-dimensional structure of α1-antitrypsin for structure and function of serpins. Biochemistry 28, 8951-8966.
    • (1989) Biochemistry , vol.28 , pp. 8951-8966
    • Huber, R.1    Carrell, R.W.2
  • 12
    • 0035853801 scopus 로고    scopus 로고
    • α1-Proteinase inhibitor, α1-antichymotrypsin, and α2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells
    • Ikari, Y., Mulvihill, E., and Schwartz, S.M. (2001). α1-Proteinase inhibitor, α1-antichymotrypsin, and α2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J. Biol. Chem. 276, 11798-11803.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11798-11803
    • Ikari, Y.1    Mulvihill, E.2    Schwartz, S.M.3
  • 15
    • 34247884585 scopus 로고    scopus 로고
    • α1-Antitrypsin, old dog, new tricks. α1-Antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP
    • Janciauskiene, S., Nita, I.M., and Stevens, T. (2007). α1-Antitrypsin, old dog, new tricks. α1-Antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP. J. Biol. Chem. 282, 8573-8582.
    • (2007) J. Biol. Chem. , vol.282 , pp. 8573-8582
    • Janciauskiene, S.1    Nita, I.M.2    Stevens, T.3
  • 17
    • 79953250407 scopus 로고    scopus 로고
    • Alpha 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells
    • Kalis, M., Kumar, R., Janciauskiene, S., Salehi, A., and Cilio, C.M. (2010). Alpha 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. Islets 2, 185-189.
    • (2010) Islets , vol.2 , pp. 185-189
    • Kalis, M.1    Kumar, R.2    Janciauskiene, S.3    Salehi, A.4    Cilio, C.M.5
  • 18
    • 3343020727 scopus 로고    scopus 로고
    • α1-Antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains
    • Knappstein, S., Ide, T., Schmidt, M.A., and Heusipp, G. (2004). α1-Antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains. Infect. Immun. 72, 4344-4350.
    • (2004) Infect. Immun. , vol.72 , pp. 4344-4350
    • Knappstein, S.1    Ide, T.2    Schmidt, M.A.3    Heusipp, G.4
  • 21
    • 84865214922 scopus 로고    scopus 로고
    • Expanding the clinical indications for α1-antitrypsin therapy
    • Lewis, E.C. (2012). Expanding the clinical indications for α1-antitrypsin therapy. Mol. Med. 18, 957-970.
    • (2012) Mol. Med. , vol.18 , pp. 957-970
    • Lewis, E.C.1
  • 22
    • 24644461309 scopus 로고    scopus 로고
    • α1-Antitrypsin monotherapy prolongs islet allograft survival in mice
    • Lewis, E.C., Shapiro, L., Bowers, O.J., and Dinarello, C.A. (2005). α1-Antitrypsin monotherapy prolongs islet allograft survival in mice. Proc. Natl. Acad. Sci. USA 102, 12153-12158.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 12153-12158
    • Lewis, E.C.1    Shapiro, L.2    Bowers, O.J.3    Dinarello, C.A.4
  • 24
    • 0030442778 scopus 로고    scopus 로고
    • α1-Antitrypsin inhibits the lethal response to TNF in mice
    • Libert, C., Van Molle, W., Brouckaert, P., and Fiers, W. (1996). α1-Antitrypsin inhibits the lethal response to TNF in mice. J. Immunol. 157, 5126-5129.
    • (1996) J. Immunol. , vol.157 , pp. 5126-5129
    • Libert, C.1    Van Molle, W.2    Brouckaert, P.3    Fiers, W.4
  • 25
  • 26
    • 77958066901 scopus 로고    scopus 로고
    • Intradermal α1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycemia in the NOD mouse model of the disease
    • Ma, H., Lu, Y., Li, H., Campbell-Thompson, M., Parker, M., Wasserfall, C., Haller, M., Brantly, M., Schatz, D., Atkinson, M., et al. (2010). Intradermal α1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycemia in the NOD mouse model of the disease. Diabetologia 53, 2198-2204.
    • (2010) Diabetologia , vol.53 , pp. 2198-2204
    • Ma, H.1    Lu, Y.2    Li, H.3    Campbell-Thompson, M.4    Parker, M.5    Wasserfall, C.6    Haller, M.7    Brantly, M.8    Schatz, D.9    Atkinson, M.10
  • 27
    • 80855128776 scopus 로고    scopus 로고
    • Inhibition of IL-32 activation by α1-antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model
    • Marcondes, A.M., Li, X., Tabellini, L., Bartenstein, M., Kabacka, J., Sale, G.E., Hansen, J.A., Dinarello, C.A., and Deeg, H.J. (2011). Inhibition of IL-32 activation by α1-antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model. Blood 118, 5031-5039.
    • (2011) Blood , vol.118 , pp. 5031-5039
    • Marcondes, A.M.1    Li, X.2    Tabellini, L.3    Bartenstein, M.4    Kabacka, J.5    Sale, G.E.6    Hansen, J.A.7    Dinarello, C.A.8    Deeg, H.J.9
  • 30
    • 84991202826 scopus 로고    scopus 로고
    • Prolastin, a pharmaceutical preparation of purified human αI-antitrypsin, blocks endotoxin-mediated cytokine release
    • Nita, I., Hollander, C., Westin, U., and Janciauskiene, S.M. (2005). Prolastin, a pharmaceutical preparation of purified human αI-antitrypsin, blocks endotoxin-mediated cytokine release. Resp. Res. 6, 12.
    • (2005) Resp. Res. , vol.6 , pp. 12
    • Nita, I.1    Hollander, C.2    Westin, U.3    Janciauskiene, S.M.4
  • 31
    • 34249332725 scopus 로고    scopus 로고
    • α1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro
    • Nita, I., Serapinas, D., and Janciauskiene, S.M. (2007). α1- Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro. Int. J. Biochem. Cell Biol. 39, 1165-1176.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1165-1176
    • Nita, I.1    Serapinas, D.2    Janciauskiene, S.M.3
  • 32
    • 84862860546 scopus 로고    scopus 로고
    • α-1 Antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells
    • Ozeri, E., Mizrahi, M., Sharaf, G., and Lewis, E.C. (2012). α-1 Antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells. J. Immunol. 189, 146-153.
    • (2012) J. Immunol. , vol.189 , pp. 146-153
    • Ozeri, E.1    Mizrahi, M.2    Sharaf, G.3    Lewis, E.C.4
  • 34
    • 65549125443 scopus 로고    scopus 로고
    • α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood
    • Pott, G.B., Chan, E.D., Dinarello, C.A., and Shapiro, L. (2009). α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J. Leukoc. Biol. 85, 886-895.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 886-895
    • Pott, G.B.1    Chan, E.D.2    Dinarello, C.A.3    Shapiro, L.4
  • 36
    • 45949100430 scopus 로고    scopus 로고
    • Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity
    • Shpacovitch, V., Feld, M., Hollenberg, M.D., Luger, T.A., and Steinhoff, M. (2008). Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J. Leukoc. Biol. 83, 1309-1322.
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 1309-1322
    • Shpacovitch, V.1    Feld, M.2    Hollenberg, M.D.3    Luger, T.A.4    Steinhoff, M.5
  • 38
    • 24644454164 scopus 로고    scopus 로고
    • Saving islets from allograft rejection
    • Strom, T.B. (2005). Saving islets from allograft rejection. Proc. Natl. Acad. Sci. USA 102, 12651-12652.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 12651-12652
    • Strom, T.B.1
  • 40
    • 79959379140 scopus 로고    scopus 로고
    • Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice
    • Subramanian, S., Shahaf, G., Ozeri, E., Miller, L.M., Vandenbark, A.A., Lewis, E.C., and Offner, H. (2011). Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice. Metab. Brain Dis. 26, 107-113.
    • (2011) Metab. Brain Dis. , vol.26 , pp. 107-113
    • Subramanian, S.1    Shahaf, G.2    Ozeri, E.3    Miller, L.M.4    Vandenbark, A.A.5    Lewis, E.C.6    Offner, H.7
  • 41
    • 84862908801 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation
    • Tawara, I., Sun, Y., Lewis, E.C., Toubai, T., Evers, R., Nieves, E., Azam, T., Dinarello, C.A., and Reddy, P. (2012). Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation. Proc. Natl. Acad. Sci. USA 109, 564-569.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 564-569
    • Tawara, I.1    Sun, Y.2    Lewis, E.C.3    Toubai, T.4    Evers, R.5    Nieves, E.6    Azam, T.7    Dinarello, C.A.8    Reddy, P.9
  • 42
    • 0027485021 scopus 로고
    • Antiinflammatory properties of hepatic acute phase proteins: Preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1β synthesis by human peripheral blood mononuclear cells
    • Tilg, H., Vannier, E., Vachino, G., Dinarello, C.A., and Mier, J.W. (1993). Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1β synthesis by human peripheral blood mononuclear cells. J. Exp. Med. 178, 1629-1636.
    • (1993) J. Exp. Med. , vol.178 , pp. 1629-1636
    • Tilg, H.1    Vannier, E.2    Vachino, G.3    Dinarello, C.A.4    Mier, J.W.5
  • 43
    • 0023695960 scopus 로고
    • Antiproteinases protect cultured lung endothelial cells from endotoxin injury
    • Tumen, J., Meyrick, B., Berry, L., and Brigham, K.L. (1988). Antiproteinases protect cultured lung endothelial cells from endotoxin injury. J. Appl. Physiol. 65, 835-843.
    • (1988) J. Appl. Physiol. , vol.65 , pp. 835-843
    • Tumen, J.1    Meyrick, B.2    Berry, L.3    Brigham, K.L.4
  • 44
    • 0031252371 scopus 로고    scopus 로고
    • α1-Acid glycoprotein and α1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice
    • Van Molle, W., Libert, C., Fiers, W., and Brouckaert, P. (1997). α1-Acid glycoprotein and α1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice. J. Immunol. 159, 3555-3564.
    • (1997) J. Immunol. , vol.159 , pp. 3555-3564
    • Van Molle, W.1    Libert, C.2    Fiers, W.3    Brouckaert, P.4


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