Inactivation of AMPK mediates high phosphate-induced extracellular matrix accumulation via NOX4/TGFβ-1 signaling in human mesangial cells

Cellular Physiology and Biochemistry

Volumn 34, Issue 4, 2014, Pages 1260-1272

  Papadimitriou, Alexandros ^a   Peixoto, Elisa B M I ^a   Silva, Kamila C ^a   Lopes De Faria, Jacqueline M ^a   Lopes De Faria, José B ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

AMPK; Extracellular matrix accumulation; Mesangial cells; NOX4; Phosphate; Transforming growth factor 1

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 4; FIBRONECTIN; HYDROETHIDINE; LUCIGENIN; PHOSPHATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD3 PROTEIN; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA1; ACTA2 PROTEIN, HUMAN; ACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NOX4 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MESANGIUM CELL; PROTEIN EXPRESSION; WESTERN BLOTTING; CELL CULTURE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTINS; AMP-ACTIVATED PROTEIN KINASES; CELLS, CULTURED; COLLAGEN TYPE IV; EXTRACELLULAR MATRIX; FIBRONECTINS; HUMANS; MESANGIAL CELLS; NADPH OXIDASE; PHOSPHATES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SUPEROXIDES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84908615597     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000366336     Document Type: Article

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